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Showing 1–12 of 12 results
Advanced filters: Author: Aiming Ren Clear advanced filters

  • A riboswitch that binds fluoride was identified recently, which is surprising because both RNA and fluoride are negatively charged; here it is shown that the fluoride ion is coordinated to three positively charged magnesium ions, which are further encased in a negatively charged shell of RNA backbone phosphates and water molecules.

    • Aiming Ren
    • Kanagalaghatta R. Rajashankar
    • Dinshaw J. Patel
    Research
    Nature
    Volume: 486, P: 85-89

  • Twisters ribozymes are a recently discovered class of non-coding, site-specific self-cleaving RNAs. Here Ren et al. describe a crystal structure of the env22twister ribozyme, propose an ion coordination and catalytic mechanism, and contrast their findings with those of two recently reported twister structures.

    • Aiming Ren
    • Marija KoÅ¡utić
    • Dinshaw J. Patel
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Structural analysis of the Pepper aptamer in complex with its cognate HBC or HBC-like color variants reveals that it binds fluorophore molecules via one non-G-quadruplex base quadruple and one noncanonical G·U base pair.

    • Kaiyi Huang
    • Xianjun Chen
    • Aiming Ren
    Research
    Nature Chemical Biology
    Volume: 17, P: 1289-1295

  • Huang et al. report the tertiary structure of a small monomeric fluorogenic RNA aptamer named Clivia, characterized by a large Stokes shift, revealing the fluorescence activation mechanism and enabling a multivalent design to enhance the fluorescence output at specific dye concentrations.

    • Kaiyi Huang
    • Qianqian Song
    • Aiming Ren
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 1453-1460

  • The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

    • Fan Bu
    • Yagoub Adam
    • Zhichao Miao
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 399-411

  • Achieving successful in vivo cartilage regeneration remains challenging. Here they present a cell-free, multiple hydrogen-bond crosslinked hydrogel loaded with tannic acid and Kartogenin with ultra-durable mechanical properties and stage-dependent drug release behavior to promote cartilage regeneration.

    • Yuxuan Yang
    • Xiaodan Zhao
    • Xuesi Chen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Structural and biochemical analysis of the recently discovered env25 pistol ribozyme reveal an active site containing a pseudoknot that enforces in-line nucleophilic attack at the scissile phosphate and positions nucleotides for general acid and general base catalysis.

    • Aiming Ren
    • Nikola VuÅ¡urović
    • Dinshaw J Patel
    Research
    Nature Chemical Biology
    Volume: 12, P: 702-708

  • Riboswitches are conserved RNA domains located in the non-coding region of mRNA that recognize cellular metabolites and, in turn, regulate gene expression. Here the authors report the structure of the recently identified SAM-VI riboswitch and provide insight into its mechanism of ligand discrimination.

    • Aiai Sun
    • Catherina Gasser
    • Aiming Ren
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Twister-sister is a self-cleaving ribozyme. Here, the authors report the 2.0 Å crystal structure of the four-way junctional twister-sister ribozyme in the pre-catalytic state and discuss mechanistic implications based on their mutagenesis experiments and comparisons with other ribozyme structures.

    • Luqian Zheng
    • Elisabeth Mairhofer
    • Aiming Ren
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The bacterial ydaO riboswitch senses the second messenger c-di-AMP. Crystallographic and isothermal titration calorimetry analysis reveals that ydaO binds two molecules of c-di-AMP in binding pockets related by pseudo-two-fold symmetry.

    • Aiming Ren
    • Dinshaw J Patel
    Research
    Nature Chemical Biology
    Volume: 10, P: 780-786