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Advanced filters: Author: Alberto Guarnieri Clear advanced filters

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

tDeclining YAP/TAZ mechanotransduction drives ageing by unleashing cGAS–STING signalling, a pillar of innate immunity, so sustaining YAP/TAZ mechanosignalling or inhibiting STING present promising approaches for limiting senescence-associated inflammation and improving healthy ageing.

Hanna Lucie Sladitschek-Martens
Alberto Guarnieri
Stefano Piccolo
Research29 Jun 2022
Nature

Volume: 607, P: 790-798
Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma

Piccolo and colleagues perform integrated single-cell analyses and identify YAP/TAZ regulation of glioma stem cell differentiation as a core dependency for tumor maintenance.

Martina Castellan
Alberto Guarnieri
Stefano Piccolo
Research07 Dec 2020
Nature Cancer

Volume: 2, P: 174-188

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YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma

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