Nature Search

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Determining mutational fingerprints at the human p53 locus with a yeast functional assay: a new tool for molecular epidemiology

Alberto Inga
Raffaella Iannone
Gilberto Fronza
Research20 Mar 1997
Oncogene

Volume: 14, P: 1307-1313
A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions

Alberto Inga
Dorit Nahari
Michael A Resnick
Research13 Aug 2002
Oncogene

Volume: 21, P: 5704-5715
Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants

Alberto Inga
Michael A Resnick
Research22 Jun 2001
Oncogene

Volume: 20, P: 3409-3419
Tumour p53 mutations exhibit promoter selective dominance over wild type p53

Paola Monti
Paola Campomenosi
Gilberto Fronza
Research08 Mar 2002
Oncogene

Volume: 21, P: 1641-1648
Characterization of the p53 mutants ability to inhibit p73β transactivation using a yeast-based functional assay

Paola Monti
Paola Campomenosi
Gilberto Fronza
Research14 Aug 2003
Oncogene

Volume: 22, P: 5252-5260
p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

Alberto Inga
Paola Monti
Michael A Resnick
Research12 Mar 2001
Oncogene

Volume: 20, P: 501-513
LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β

Several lncRNAs are regulated by TGF-β. Here the authors report that an intergenic lncRNA —EPR— is a component of the TGF-β signaling pathway and controls epithelial cell proliferation by altering transcription and mRNA decay of Cdkn1a. EPR overexpression restrains tumor growth of orthotopically transplanted mice.

Martina Rossi
Gabriele Bucci
Roberto Gherzi
ResearchOpen Access29 Apr 2019
Nature Communications

Volume: 10, P: 1-16
Functional composition of the Amazonian tree flora and forests

Using 13 functional traits we characterize the Amazonian trees and the communities they form. Amazonian tree communities are distributed along a fast-slow-spectrum. This results in clear differences in traits among these forests, as well as their biomass and biomass productivity.

Hans ter Steege
Lourens Poorter
Georgia Pickavance
ResearchOpen Access03 Mar 2025
Communications Biology

Volume: 8, P: 1-17
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
The trans-ancestral genomic architecture of glycemic traits

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Ji Chen
Cassandra N. Spracklen
Cornelia van Duijn
Research31 May 2021
Nature Genetics

Volume: 53, P: 840-860
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Plasma extracellular vesicles contain quantifiable amounts of TDP-43 and full-length tau, allowing the accurate assessment of pathology in frontotemporal dementia, frontotemporal dementia spectrum disorders and amyotrophic lateral sclerosis.

Madhurima Chatterjee
Selcuk Özdemir
Anja Schneider
ResearchOpen Access18 Jun 2024
Nature Medicine

Volume: 30, P: 1771-1783
A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution

The ubiquitous second messenger c-di-GMP regulates many biological processes in bacteria, including cell cycle, motility, virulence and biofilm formation. Here, Kaczmarczyk et al. develop a c-di-GMP biosensor that enables dynamic real-time tracking of c-di-GMP levels in individual living cells.

Andreas Kaczmarczyk
Simon van Vliet
Urs Jenal
ResearchOpen Access09 May 2024
Nature Communications

Volume: 15, P: 1-18
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs

In the first results from an ongoing global cancer screening data repository, screening program organization was better overall in Europe compared to other continents; however, there were substantial gaps in implementation across both high- and low-resource settings.

Li Zhang
Isabel Mosquera
Melanie Ann Layne
ResearchOpen Access27 Apr 2023
Nature Medicine

Volume: 29, P: 1135-1145
SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy

Lauria et al. show that SMN, the loss of which causes spinal muscular atrophy (SMA), preferentially positions ribosomes within the first five codons of SMA-related mRNAs and enhances their translation.

Fabio Lauria
Paola Bernabò
Gabriella Viero
Research21 Sept 2020
Nature Cell Biology

Volume: 22, P: 1239-1251
p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements

Paola Campomenosi
Paola Monti
Gilberto Fronza
Research27 Jun 2001
Oncogene

Volume: 20, P: 3573-3579
Inherited determinants of early recurrent somatic mutations in prostate cancer

Prostate cancer is a heterogeneous disease, and many cases show somatic mutations of SPOP. Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone dependent DNA damage response.

Alessandro Romanel
Sonia Garritano
Francesca Demichelis
ResearchOpen Access29 Jun 2017
Nature Communications

Volume: 8, P: 1-10
The expanding universe of p53 targets

Target response element sequences are a crucial part of the p53 network. This Review describes how functional response elements can be defined and discusses the implications of non-canonical p53 response elements, which greatly expand the universe of p53-regulated genes, on the part that p53 plays as a tumour suppressor.

Daniel Menendez
Alberto Inga
Michael A. Resnick
Reviews01 Oct 2009
Nature Reviews Cancer

Volume: 9, P: 724-737
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
A highly specific SpCas9 variant is identified by in vivo screening in yeast

Evolved SpCas9 variant evoCas9 has improved specificity and retains near wild-type on-target activity.

Antonio Casini
Michele Olivieri
Anna Cereseto
Research29 Jan 2018
Nature Biotechnology

Volume: 36, P: 265-271
Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Protective immune mechanism induced by live-attenuated double-deleted L. monocytogenes ∆actA/∆inlB vaccine strain delivering tumor antigens keeps hepatobiliary malignancies under control. Live-attenuated, double-deleted L. monocytogenes ∆actA/∆inlB strain expressing model tumor antigen was used in both, prophylactic and therapeutic vaccination settings. Vaccination was safe and led to: (i) induction of protective tumor-specific Th1 immune responses in premalignant and malignant stages and strong increase of tumor-specific IFN-ɣ⁺ CD4 and CD8 T cells; (ii) decrease of T regulatory cells; (iii) downregulation of several tumor-promoting ICI molecules (PD-1, CD160, LAG3, 4-1BBL) on CD4/CD8 T lymphocytes; (iv) decrease of tumor-specific IgG in serum, and (v) decrease of B lymphocytes, DC and MΦ locally in livers. iCCA, intrahepatic cholangiocarcinoma.

Inga Hochnadel
Lisa Hoenicke
Tetyana Yevsa
ResearchOpen Access16 Feb 2022
Oncogene

Volume: 41, P: 2039-2053
Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

Despite a growing emphasis on biomarkers in research into Alzheimer disease (AD) and Parkinson disease (PD), there is little consensus as to which biomarkers are most effective. In this Review, Lleó and colleagues discuss cerebrospinal fluid (CSF) biomarkers for AD and PD, with a particular emphasis on applicability to clinical trials. Compared with AD, less is known about CSF biomarkers in PD, and the authors highlight several areas for further research.

Alberto Lleó
Enrica Cavedo
Brit Mollenhauer
Reviews16 Dec 2014
Nature Reviews Neurology

Volume: 11, P: 41-55
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Thomas Chatzikonstantinou
Anargyros Kapetanakis
Paolo Ghia
ResearchOpen Access01 Nov 2021
Leukemia

Volume: 35, P: 3444-3454
Regulatory Crosstalk of Doxorubicin, Estradiol and TNFα Combined Treatment in Breast Cancer-derived Cell Lines

Isar Nassiri
Alberto Inga
Corrado Priami
ResearchOpen Access23 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q

Enjie Zhang
Victoria E. Cotton
Nicola J. Royle
ResearchOpen Access07 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Correction: Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Inga Hochnadel
Lisa Hoenicke
Tetyana Yevsa
Amendments and CorrectionsOpen Access13 Apr 2022
Oncogene

Volume: 41, P: 2787
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto Romagnoni
Simon Jégou
Pamela Whittaker
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-18

Search

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Determining mutational fingerprints at the human p53 locus with a yeast functional assay: a new tool for molecular epidemiology

A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants

Tumour p53 mutations exhibit promoter selective dominance over wild type p53

Characterization of the p53 mutants ability to inhibit p73β transactivation using a yeast-based functional assay

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β

Functional composition of the Amazonian tree flora and forests

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

The trans-ancestral genomic architecture of glycemic traits

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution

CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs

SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy

p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements

Inherited determinants of early recurrent somatic mutations in prostate cancer

The expanding universe of p53 targets

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A highly specific SpCas9 variant is identified by in vivo screening in yeast

Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Regulatory Crosstalk of Doxorubicin, Estradiol and TNFα Combined Treatment in Breast Cancer-derived Cell Lines

HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q

Correction: Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

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