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Fundamental questions in meiofauna research highlight how small but ubiquitous animals can improve our understanding of Nature

This paper identifies the top-50 priority questions for meiofaunal research, highlighting their critical roles in biogeochemical cycles and biodiversity. It calls for a balanced research agenda, international cooperation, and advances in technology to overcome current challenges and unlock meiofauna’s full potential.

Alejandro Martínez
Stefano Bonaglia
Diego Fontaneto
Comments & OpinionOpen Access17 Mar 2025
Communications Biology

Volume: 8, P: 1-17
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Whole-mount smFISH allows combining RNA and protein quantification at cellular and subcellular resolution

Zhao et al. have developed a method to detect and quantify single molecules of RNA in several intact plant tissues. The method can also be used to simultaneously quantify and locate mRNAs and proteins in single cells with subcellular resolution.

Lihua Zhao
Alejandro Fonseca
Stefanie Rosa
ResearchOpen Access15 Jun 2023
Nature Plants

Volume: 9, P: 1094-1102
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

GM-CSF is involved in control over M. tuberculosis infection. Here the authors show that GM-CSF reduces type 1 interferon driven neutrophil recruitment, NETosis and bacterial growth in the lungs of infected mice, and provide evidence that this NETosis occurs in infected humans who are not responsive to antibiotic therapy.

Lúcia Moreira-Teixeira
Philippa J. Stimpson
Anne O’Garra
ResearchOpen Access04 Nov 2020
Nature Communications

Volume: 11, P: 1-18
Non-structural carbohydrates mediate seasonal water stress across Amazon forests

The role of non-structural carbohydrates (NSC) in mediating the impacts of drought in tropical trees is unclear. Here, the authors analyse leaf and branch NSC in 82 Amazon tree species across a Basin-wide precipitation gradient, finding that allocation of leaf NSC to soluble sugars is higher in drier sites and is coupled to tree hydraulic status.

Caroline Signori-Müller
Rafael S. Oliveira
David Galbraith
ResearchOpen Access19 Apr 2021
Nature Communications

Volume: 12, P: 1-9
Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

Cross-neutralization assays of early variants and the 501Y.V2 variant of SARS-CoV-2 show that plasma from individuals infected with 501Y.V2 effectively neutralizes all variants, indicating that a vaccine that targets 501Y.V2 may also be effective against other SARS-CoV-2 variants.

Sandile Cele
Inbal Gazy
Alex Sigal
Research29 Mar 2021
Nature

Volume: 593, P: 142-146
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

The pathobiological validity of mouse models of mycobacteria infection is sometimes questioned. O’Garra and colleagues demonstrate that mice share transcriptomic modules with active human tuberculosis and a characteristic type I IFN signature.

Lúcia Moreira-Teixeira
Olivier Tabone
Anne O’Garra
Research16 Mar 2020
Nature Immunology

Volume: 21, P: 464-476
GPCRmd uncovers the dynamics of the 3D-GPCRome

GPCRmd is a community-driven online platform to visualize, analyze and share G-protein-coupled receptor (GPCR) molecular dynamics data. It currently contains simulation data representing 100% of GPCR classes, 71% of receptor subtypes and 80% of GPCR families.

Ismael Rodríguez-Espigares
Mariona Torrens-Fontanals
Jana Selent
Research13 Jul 2020
Nature Methods

Volume: 17, P: 777-787
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Evaluating social protection mitigation effects on HIV/AIDS and Tuberculosis through a mathematical modelling study

Felipe Alves Rubio
Alan Alves Santana Amad
Davide Rasella
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-8
Augmented Acquisition of Cocaine Self-Administration and Altered Brain Glucose Metabolism in Adult Female but not Male Rats Exposed to a Cannabinoid Agonist during Adolescence

Alejandro Higuera-Matas
María Luisa Soto-Montenegro
Emilio Ambrosio
Research06 Jun 2007
Neuropsychopharmacology

Volume: 33, P: 806-813
Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients

Veronica Velasco-Durantez
Patricia Cruz-Castellanos
Paula Jiménez-Fonseca
ResearchOpen Access07 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

Jose Manuel Sánchez-Maldonado
Manuel Martínez-Bueno
Juan Sainz
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-13
Radiomics and outcome prediction to antiangiogenic treatment in advanced gastroenteropancreatic neuroendocrine tumours: findings from the phase II TALENT trial

Marta Ligero
Jorge Hernando
Raquel Perez-Lopez
ResearchOpen Access02 Aug 2023
BJC Reports

Volume: 1, P: 1-8
Copper–cobalt double metal cyanides as green catalysts for phosphoramidate synthesis

Molecular framework materials have shown great promise as heterogeneous catalysts, but understanding the structural changes that such catalysts suffer over time remains challenging. Here, the environment around the metal centers of a Cu₃[Co(CN)₆]₂-based double metal cyanide catalyst is studied before and after the synthesis of several phosphoramidates via an environmentally friendly route.

Alejandro Fonseca
Aram L. Bugaev
Dirk De Vos
ResearchOpen Access05 Jul 2023
Communications Chemistry

Volume: 6, P: 1-14
Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Marta Varela-Eirín
Paula Carpintero-Fernández
María D. Mayán
ResearchOpen Access05 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-13
Optimal control of the COVID-19 pandemic: controlled sanitary deconfinement in Portugal

Cristiana J. Silva
Carla Cruz
Jorge Mira
ResearchOpen Access10 Feb 2021
Scientific Reports

Volume: 11, P: 1-15
Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

Jose M. Sánchez-Maldonado
Rafael Cáliz
Juan Sainz
ResearchOpen Access15 Oct 2019
Scientific Reports

Volume: 9, P: 1-16
Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients

Luz M. Canet
Jose M. Sánchez-Maldonado
Juan Sainz
Research05 Oct 2018
The Pharmacogenomics Journal

Volume: 19, P: 83-96
Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Martin Kerick
Marialbert Acosta-Herrera
Javier Martin
ResearchOpen Access05 Oct 2022
npj Genomic Medicine

Volume: 7, P: 1-12
Immune digital twins for complex human pathologies: applications, limitations, and challenges

Anna Niarakis
Reinhard Laubenbacher
James A. Glazier
ReviewsOpen Access30 Nov 2024
npj Systems Biology and Applications

Volume: 10, P: 1-14
Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study

Sergio Matarraz
Pilar Leoz
Alberto Orfao
CorrespondenceOpen Access04 Sept 2023
Blood Cancer Journal

Volume: 13, P: 1-5
Enhanced, coordinated conservation efforts required to avoid extinction of critically endangered Eastern Pacific leatherback turtles

Marino Eugenio Ábrego
Nicolás Acuña-Perales
Patricia M. Zárate
ResearchOpen Access16 Mar 2020
Scientific Reports

Volume: 10, P: 1-14
30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Rishi Singhal
Victor Roth Cardoso
Mehmet Saydam
ResearchOpen Access15 Dec 2021
International Journal of Obesity

Volume: 46, P: 750-757
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients

Luz M. Canet
Jose M. Sánchez-Maldonado
Juan Sainz
Amendments and Corrections14 Feb 2019
The Pharmacogenomics Journal

Volume: 19, P: 582

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