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Showing 1–24 of 24 results
Advanced filters: Author: Alex Cagan Clear advanced filters

  • Mutational signature analysis of blood cells isolated from 23 chemotherapy-exposed samples and 9 nonexposed controls characterizes the effects of various drugs on mutational burden, signature exposure and cell types.

    • Emily Mitchell
    • My H. Pham
    • Michael R. Stratton
    ResearchOpen Access
    Nature Genetics
    P: 1-11

  • Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms underlying the remarkable cancer resistance of some taxa. Therefore, this Perspective by Vincze et al. calls for the increased use of non-conventional model organisms in cancer research to advance cancer prevention and treatment strategies.

    • Orsolya Vincze
    • Benjamin Spada
    • Thomas Pradeu
    Reviews
    Nature Reviews Cancer
    P: 1-9

  • This Review describes the changes that some organisms make to their own DNA sequences, linking many to common genetic mechanisms built around canonical DNA repair and to a set of functional circumstances that often involve host–pathogen conflicts.

    • Vincent C. T. Hanlon
    • Alex Cagan
    • Sebastian Eves-van den Akker
    Reviews
    Nature Genetics
    P: 1-12

  • Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using laboratory mice to study stem cell ageing.

    • Chiraag D. Kapadia
    • Nicholas Williams
    • Jyoti Nangalia
    ResearchOpen Access
    Nature
    Volume: 641, P: 681-689

  • Whole-genome sequencing is used to analyse the landscape of somatic mutation in intestinal crypts from 16 mammalian species, revealing that rates of somatic mutation inversely scale with the lifespan of the animal across species.

    • Alex Cagan
    • Adrian Baez-Ortega
    • Iñigo Martincorena
    ResearchOpen Access
    Nature
    Volume: 604, P: 517-524

  • Combining Drosophila genetics with chemistry and computation led to the development of novel kinase inhibitors based on the RAF-targeting drug sorafenib that reveal the RET oncogene as an enhancer of drug action and improve the therapeutic window in medullary thyroid carcinoma models.

    • Masahiro Sonoshita
    • Alex P Scopton
    • Arvin C Dar
    Research
    Nature Chemical Biology
    Volume: 14, P: 291-298

  • The authors report the mutational landscape of 29 cell types from microdissected biopsies from 19 organs and explore the mechanisms underlying mutation rates in normal tissues.

    • Luiza Moore
    • Alex Cagan
    • Raheleh Rahbari
    Research
    Nature
    Volume: 597, P: 381-386

  • Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

    • A. Cole Burton
    • Christopher Beirne
    • Roland Kays
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 8, P: 924-935

  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282

  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141

  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511

  • Sequencing of individual human lymphocyte clones shows that they are highly prone to mutations, with higher burdens in memory cells than in naive cells arising from mutational processes associated with differentiation and tissue residency.

    • Heather E. Machado
    • Emily Mitchell
    • Peter J. Campbell
    ResearchOpen Access
    Nature
    Volume: 608, P: 724-732

  • The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal their somatic evolution and clonal diversification, as well as identify several putative biomarkers for treatment stratification.

    • Thomas R. W. Oliver
    • Lia Chappell
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Haematopoiesis has high clonal diversity up to about 65 years of age, after which diversity drops precipitously owing to positive selection acting on a handful of clones that expand exponentially throughout adulthood.

    • Emily Mitchell
    • Michael Spencer Chapman
    • Peter J. Campbell
    ResearchOpen Access
    Nature
    Volume: 606, P: 343-350

  • NanoSeq is used to detect mutations in single DNA molecules and analyses show that mutational processes that are independent of cell division are important contributors to somatic mutagenesis.

    • Federico Abascal
    • Luke M. R. Harvey
    • Iñigo Martincorena
    Research
    Nature
    Volume: 593, P: 405-410

  • Laurent Frantz and colleagues report an analysis of 103 whole genomes from European and Asian wild boars and domestic pigs. They find evidence in support of a complex domestication model with gene flow from wild populations counteracted by recurrent artificial selection for traits important for domestication.

    • Laurent A F Frantz
    • Joshua G Schraiber
    • Martien A M Groenen
    Research
    Nature Genetics
    Volume: 47, P: 1141-1148

  • Bayesian hierarchical regression analysis of a global database of bird introduction events reveals the environmental, climatic and biotic factors that are the primary determinants of the successful establishment of populations of alien species.

    • David W. Redding
    • Alex L. Pigot
    • Tim M. Blackburn
    Research
    Nature
    Volume: 571, P: 103-106