Nature Search

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation

Covalent inhibitors that selectively target bacterial enzymes are potential antibiotic drug candidates. Here, the authors apply high-throughput screening to identify selective covalent inhibitors that target serine hydrolases in Staphylococcus aureus

Tulsi Upadhyay
Emily C. Woods
Matthew Bogyo
ResearchOpen Access30 May 2025
Nature Communications

Volume: 16, P: 1-19
Unveiling cellular communications through rapid pan-membrane-protein labeling

Rapid, high-density labelling methods for multiplexed live cell imaging remain scarce. Using NHS-ester fluorescent dyes, the authors use multiplexed superresolution imaging to perform pan-membrane-protein labelling of mammalian cells. The study sheds light on membrane topology dynamics and cell-cell interactions.

Hirushi Gunasekara
Yu-Shiuan Cheng
Ying S. Hu
ResearchOpen Access15 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Chemoenzymatic synthesis of differentially protected 3-deoxysugars

Ready access to sugars in which the various hydroxyl groups are differentially protected will be of benefit in the production of vaccines, antibiotics and drugs. Here, a chemoenzymatic method that provides a direct route to such protected sugars is described.

Dennis G. Gillingham
Pierre Stallforth
Donald Hilvert
Research17 Jan 2010
Nature Chemistry

Volume: 2, P: 102-105
Correction: Corrigendum: Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

Alexander Adibekian
Brent R Martin
Benjamin F Cravatt
Amendments and Corrections15 Feb 2012
Nature Chemical Biology

Volume: 8, P: 318
Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Deoxyelephantopin is a naturally occurring sesquiterpene lactone with known anticancer properties. Here, the authors synthesize deoxyelephantopins and a range of analogues including alkyne-tagged probes, using them to identify its cellular targets.

Roman Lagoutte
Christelle Serba
Nicolas Winssinger
ResearchOpen Access19 Aug 2016
Nature Communications

Volume: 7, P: 1-11
Programming inactive RNA-binding small molecules into bioactive degraders

Small-molecule RNA-targeted degradation can be leveraged to convert strong, yet inactive, binding interactions into potent and specific modulators of RNA function.

Yuquan Tong
Yeongju Lee
Matthew D. Disney
ResearchOpen Access24 May 2023
Nature

Volume: 618, P: 169-179
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

A selection-based screen has now revealed preferences in small-molecule chemotypes that bind RNA as well as preferences in the RNA motifs that bind small molecules. Analysis of these data enabled the design of a small molecule that selectively binds a non-coding microRNA and upregulates expression of vascular endothelial growth factor A.

Hafeez S. Haniff
Laurent Knerr
Matthew D. Disney
Research24 Aug 2020
Nature Chemistry

Volume: 12, P: 952-961
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding

Anoxia─lack of oxygen─commonly occurs during ischaemic heart disease. Using yeast, worms and mice, Hannich et al. show that anoxia-associated tissue injury and cell death are due to accumulation of a non-canonical sphingolipid, 1-deoxydihydroceramide, that damages the cytoskeleton.

J. Thomas Hannich
A. Galih Haribowo
Howard Riezman
Research14 Oct 2019
Nature Metabolism

Volume: 1, P: 996-1008
Global profiling of dynamic protein palmitoylation

A quantitative proteomics approach to characterize protein palmitoylation dynamics on a global scale in cells, as well as to identify enzymes responsible for the regulation of palmitoylation, is described.

Brent R Martin
Chu Wang
Benjamin F Cravatt
Research06 Nov 2011
Nature Methods

Volume: 9, P: 84-89
A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

A semisynthetic carbohydrate-lipid vaccine that combines a known adjuvant that has been used in disease models with a lipid capable of activating iNKT cells protects against Streptococcus pneumoniae infection in mice.

Marco Cavallari
Pierre Stallforth
Gennaro De Libero
Research05 Oct 2014
Nature Chemical Biology

Volume: 10, P: 950-956
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation

Hiroyuki Arai and colleagues characterize a new group of epoxy ω-3 fatty acid–derived proinflammatory lipid mediators, an enzyme mediating their biosynthesis and a signaling pathway by which they regulate a threshold of mast cell activation and anaphylaxis, revealing new targets for mast cell–mediated diseases.

Yuta Shimanaka
Nozomu Kono
Hiroyuki Arai
Research09 Oct 2017
Nature Medicine

Volume: 23, P: 1287-1297
DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

Potent, selective inhibitors reveal that DAGLβ is a principal 2-AG biosynthetic enzyme and regulates inflammatory processes in mouse peritoneal macrophages.

Ku-Lung Hsu
Katsunori Tsuboi
Benjamin F Cravatt
Research28 Oct 2012
Nature Chemical Biology

Volume: 8, P: 999-1007
Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

Investigations of serine hydrolases have been frustrated by a lack of selective chemical inhibitors. Profiling of synthetically accessible 1,2,3-triazole ureas in cells and mice now identifies several effective compounds, application of which yields new insights into N-acetylation by APEH.

Alexander Adibekian
Brent R Martin
Benjamin F Cravatt
Research15 May 2011
Nature Chemical Biology

Volume: 7, P: 469-478

Search

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation

Unveiling cellular communications through rapid pan-membrane-protein labeling

Chemoenzymatic synthesis of differentially protected 3-deoxysugars

Correction: Corrigendum: Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Programming inactive RNA-binding small molecules into bioactive degraders

Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding

Global profiling of dynamic protein palmitoylation

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

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