Nature Search

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials

Gennaro Pagano
Dylan Trundell
Stefano Zanigni
ResearchOpen Access01 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-8
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Exploratory digital outcome measures of motor sign progression in Parkinson’s disease patients treated with prasinezumab

Kirsten I. Taylor
Florian Lipsmeier
Stefano Zanigni
ResearchOpen Access16 Jun 2025
npj Digital Medicine

Volume: 8, P: 1-12
A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine

Despite new treatment options, prognosis for patients with glioblastoma (GBM) remains poor. Here the authors report the clinical course of patients with GBM treated with a personalized neoantigen-derived peptide vaccine treated within the scope of an individual healing attempt.

Pauline Latzer
Henning Zelba
Saskia Biskup
ResearchOpen Access11 Aug 2024
Nature Communications

Volume: 15, P: 1-9
Data linkage to evaluate the long-term risk of HIV infection in individuals seeking post-exposure prophylaxis

Individuals seeking post-exposure prophylaxis (PEP) for HIV may represent an important risk group for future HIV infection. Here the authors find HIV infections at long-term follow-up in 22 of 348 men who have sex with men, and 0 of 623 other PEP seekers.

Frédérique Hovaguimian
Huldrych F. Günthard
S. Yerly
ResearchOpen Access22 Feb 2021
Nature Communications

Volume: 12, P: 1-8
Antigen footprint governs activation of the B cell receptor

The antigen-B-cell-receptor interaction is the driving force of terminal B cell development that spans from B cell activation to antibody secreting plasma cells. Here authors determine, using DNA-PAINT super-resolution microscopy, how antigen affinity and valency define antigen binding to BCR in an in vitro system allowing precision control of these parameters.

Alexey Ferapontov
Marjan Omer
Søren Egedal Degn
ResearchOpen Access22 Feb 2023
Nature Communications

Volume: 14, P: 1-20
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
ResearchOpen Access08 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

Nikolay S. Markov
Ziyou Ren
Brian White
Research13 Aug 2024
Nature Immunology

Volume: 25, P: 1607-1622
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Stuart Macregor, Tien Wong and colleagues report meta-analyses that identify 16 new loci associated with central corneal thickness. They also identify two loci associated with risk of developing keratoconus, a common corneal ectasia.

Yi Lu
Veronique Vitart
Tien Y Wong
Research06 Jan 2013
Nature Genetics

Volume: 45, P: 155-163
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Integration of GWAS and single-cell transcriptomic data from the entire nervous system systematically identifies cell types underlying brain complex traits and provides insights into the etiology of Parkinson’s disease.

Julien Bryois
Nathan G. Skene
Patrick F. Sullivan
Research27 Apr 2020
Nature Genetics

Volume: 52, P: 482-493
Sign language experience has little effect on face and biomotion perception in bimodal bilinguals

Jessica M. Lammert
Alexandra T. Levine
Blake E. Butler
ResearchOpen Access15 Sept 2023
Scientific Reports

Volume: 13, P: 1-14
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Genome-wide analyses identify eight independent loci associated with anorexia nervosa. Genetic correlations implicate both psychiatric and metabolic components in the etiology of this disorder, even after adjusting for the effects of common variants associated with body mass index.

Hunna J. Watson
Zeynep Yilmaz
Cynthia M. Bulik
Research15 Jul 2019
Nature Genetics

Volume: 51, P: 1207-1214
Preference uncertainty accounts for developmental effects on susceptibility to peer influence in adolescence

People often change their preferences to conform with others. Using a longitudinal design, the authors show that such conformity decreases over the course of adolescence and that this reduction in conformity is accompanied by a decreasing degree of uncertainty about what to like.

Andrea M. F. Reiter
Michael Moutoussis
Raymond J. Dolan
ResearchOpen Access22 Jun 2021
Nature Communications

Volume: 12, P: 1-13
Assessing immunogenicity barriers of the HIV-1 envelope trimer

Liridona Maliqi
Nikolas Friedrich
Alexandra Trkola
ResearchOpen Access30 Sept 2023
npj Vaccines

Volume: 8, P: 1-14
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung, Chiea-Chuen Khor and colleagues report the results of a genome-wide association study of exfoliation syndrome. They replicate a known association at LOXL1 and identify a previously unreported association at CACNA1A.

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Research23 Feb 2015
Nature Genetics

Volume: 47, P: 387-392
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Tin Aung, Christopher Hammond and colleagues report the results of a large genome-wide association study of intraocular pressure. They identify four new loci associated with this trait and show that three of these loci are associated with risk of primary open-angle glaucoma.

Pirro G Hysi
Ching-Yu Cheng
Tin Aung
Research31 Aug 2014
Nature Genetics

Volume: 46, P: 1126-1130
Author Correction: The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors

Anna Wiedemann
Jan Stochl
Peter B. Jones
Amendments and CorrectionsOpen Access24 Mar 2025
Scientific Reports

Volume: 15, P: 1-2
Publisher Correction: Metacognitive impairments extend perceptual decision making weaknesses in compulsivity

Tobias U. Hauser
Micah Allen
Raymond J. Dolan
Amendments and CorrectionsOpen Access11 Apr 2018
Scientific Reports

Volume: 8, P: 1-2
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer
Garrett Hellenthal
Alastair Compston
Research10 Aug 2011
Nature

Volume: 476, P: 214-219
Metacognitive impairments extend perceptual decision making weaknesses in compulsivity

Tobias U. Hauser
Micah Allen
Raymond J. Dolan
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning

Nitzan Shahar
Tobias U. Hauser
Raymond J. Dolan
ResearchOpen Access05 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-9
Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia

J. D. Griffin
K. M. J. Diederen
P. C. Fletcher
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-18
Creutzfeldt-Jakob disease and the eye. I. Background and patient management

C J Lueck
G G McIlwaine
M Zeidler
Reviews01 May 2000
Eye

Volume: 14, P: 263-290
Creutzfeldt-Jakob disease and the eye. II. Ophthalmic and neuro-ophthalmic features

C J Lueck
G G McIlwaine
M Zeidler
Reviews01 May 2000
Eye

Volume: 14, P: 291-301
Potential causal association between gut microbiome and posttraumatic stress disorder

Qiang He
Wenjing Wang
Karestan C. Koenen
ResearchOpen Access31 Jan 2024
Translational Psychiatry

Volume: 14, P: 1-12
E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes

Anthony J Dicker
Claudia Popa
Nicholas A Saunders
Research06 Jun 2000
Oncogene

Volume: 19, P: 2887-2894
The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors

Anna Wiedemann
Jan Stochl
Peter B. Jones
ResearchOpen Access05 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
Correction: Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning

Nitzan Shahar
Tobias U. Hauser
Raymond J. Dolan
Amendments and CorrectionsOpen Access02 Dec 2021
Translational Psychiatry

Volume: 11, P: 1
Brain-behaviour modes of covariation in healthy and clinically depressed young people

Agoston Mihalik
Fabio S. Ferreira
Janaina Mourão-Miranda
ResearchOpen Access08 Aug 2019
Scientific Reports

Volume: 9, P: 1-11
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers

Beatrix Vécsey-Semjén
Karl-Friedrich Becker
Lukas A Huber
Research05 Jul 2002
Oncogene

Volume: 21, P: 4646-4662
Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
Amendments and CorrectionsOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-4

Search

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials

Genomics yields biological and phenotypic insights into bipolar disorder

Exploratory digital outcome measures of motor sign progression in Parkinson’s disease patients treated with prasinezumab

A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine

Data linkage to evaluate the long-term risk of HIV infection in individuals seeking post-exposure prophylaxis

Antigen footprint governs activation of the B cell receptor

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Sign language experience has little effect on face and biomotion perception in bimodal bilinguals

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Preference uncertainty accounts for developmental effects on susceptibility to peer influence in adolescence

Assessing immunogenicity barriers of the HIV-1 envelope trimer

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Author Correction: The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors

Publisher Correction: Metacognitive impairments extend perceptual decision making weaknesses in compulsivity

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Metacognitive impairments extend perceptual decision making weaknesses in compulsivity

Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning

Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia

Creutzfeldt-Jakob disease and the eye. I. Background and patient management

Creutzfeldt-Jakob disease and the eye. II. Ophthalmic and neuro-ophthalmic features

Potential causal association between gut microbiome and posttraumatic stress disorder

E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes

The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors

Correction: Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning

Brain-behaviour modes of covariation in healthy and clinically depressed young people

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers

Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

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