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Showing 1–7 of 7 results
Advanced filters: Author: Alice Giustacchini Clear advanced filters
  • Applying a new, more sensitive single-cell transcriptomics method to diagnosis, remission and progression samples from patients with chronic myeloid leukemia reveals insight into the heterogeneity of cells that resist treatment with targeted therapy, as well as into the dynamics of disease progression and its effects on nontransformed hematopoietic stem cells.

    • Alice Giustacchini
    • Supat Thongjuea
    • Adam J Mead
    Research
    Nature Medicine
    Volume: 23, P: 692-702
  • To study microRNA function in vivo, the authors optimize lentiviral-driven expression of microRNA target sequences in mice and show dose-dependent inhibition of microRNA-mediated regulation of reporter constructs as well as of natural microRNA targets. With the inhibition of a miR-223, they can phenocopy the knockout of this microRNA.

    • Bernhard Gentner
    • Giulia Schira
    • Luigi Naldini
    Research
    Nature Methods
    Volume: 6, P: 63-66
  • The identity and lineage potential of the embryonic thymus-seeding progenitors that first seed the embryonic thymic rudiment is unclear. Jacobsen and colleagues find that these cells do not include multipotent stem cells or T cell–restricted progenitors but instead are lympho-myeloid progenitors.

    • Tiago C Luis
    • Sidinh Luc
    • Sten Eirik W Jacobsen
    Research
    Nature Immunology
    Volume: 17, P: 1424-1435
  • With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.

    • Amit Grover
    • Alejandra Sanjuan-Pla
    • Claus Nerlov
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12