Nature Search

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

P: 1-13
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
A predictable conserved DNA base composition signature defines human core DNA replication origins

In metazoan the DNA sequence elements characterizing origin specification are unknown. By generating and analysing 19 SNS-seq datasets from different human cell types, the authors reveal a class and features of Core origins of replication which can be predicted by an algorithm.

Ildem Akerman
Bahar Kasaai
Marcel Méchali
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-15
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses

A metabolic modeling approach reveals druggable host cell pathways essential for viral replication across various viruses with minimal cytotoxicity. These findings highlight cellular metabolism as a promising target for antiviral therapy.

Alina Renz
Mirjam Hohner
Christoph Kaleta
ResearchOpen Access23 May 2025
Communications Biology

Volume: 8, P: 1-19
Photochemistry dominates over photothermal effects in the laser-induced reduction of graphene oxide by visible light

Laser reduction of graphene oxide is generally assumed to be primarily driven by heat. Here the authors show that light-triggered chemical reactions dominate over photothermal effects.

Maxim Fatkullin
Dmitry Cheshev
Evgeniya Sheremet
ResearchOpen Access09 Nov 2024
Nature Communications

Volume: 15, P: 1-13
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity

Bondareva and Rodríguez-Aguilera et al. use scRNA-seq to analyze transcriptomes of 375,000 endothelial cells from seven organs in male mice at various stages of obesity to identify organ-specific vulnerabilities.

Olga Bondareva
Jesús Rafael Rodríguez-Aguilera
Bilal N. Sheikh
ResearchOpen Access18 Nov 2022
Nature Metabolism

Volume: 4, P: 1591-1610
ZSCAN21 mediates the pathogenic transcriptional induction of α-synuclein in cellular and animal models of Parkinson’s disease

Alina Kozoriz
Stéphan Mora
Solange Desagher
ResearchOpen Access16 May 2025
Cell Death & Disease

Volume: 16, P: 1-15
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
A mouse model for hereditary thyroid dysgenesis and cleft palate

Mario De Felice
Catherine Ovitt
Roberto Di Lauro
Research01 Aug 1998
Nature Genetics

Volume: 19, P: 395-398
Analysis of metagenomic data

Metagenomics describes the analysis of genetic information in a microbial community to provide taxonomic or functional information on the constituent microorganisms. This Primer describes suitable sample types, sampling handling and processing workflows for metagenomics, and gives a detailed discussion of the various analysis techniques to generate meaningful information from metagenomic data.

Shaopeng Liu
Judith S. Rodriguez
Serghei Mangul
Reviews23 Jan 2025
Nature Reviews Methods Primers

Volume: 5, P: 1-28
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Common variation near ROBO2 is associated with expressive vocabulary in infancy

The genetic basis of expressive vocabulary in children around 2 years old is poorly understood. Here, the authors show that a genetic variant near the ROBO2gene is associated with early language acquisition in the general population and highlight a potential genetic link between language-related common genetic variation and a linkage region for dyslexia, speech-sound disorder and reading.

Beate St Pourcain
Rolieke A.M. Cents
George Davey Smith
ResearchOpen Access16 Sept 2014
Nature Communications

Volume: 5, P: 1-9
An integrated encyclopedia of DNA elements in the human genome

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Ian Dunham
Anshul Kundaje
Ewan Birney
ResearchOpen Access05 Sept 2012
Nature

Volume: 489, P: 57-74
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

H Rob Taal
Beate St Pourcain
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
Interrupted reactions in chemical synthesis

Interrupting a reaction reroutes the outcome of a known chemical process. This Review highlights advances that enable the redirection of common intermediates in organic chemistry to new outcomes.

Vincent Trudel
Chieh-Hung Tien
Andrei K. Yudin
Reviews04 Aug 2021
Nature Reviews Chemistry

Volume: 5, P: 604-623
A survey of dental services in England providing targeted care for people experiencing social exclusion: mapping and dimensions of access

Janine Doughty
Alina Grossman
Tim Newton
Research20 Jun 2022
British Dental Journal

P: 1-8
Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

M Arfan Ikram
Myriam Fornage
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations

Ville Karhunen
Tom A. Bond
Alina Rodriguez
ResearchOpen Access04 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-8
Towards FAIR nanosafety data

The proposal of a FAIR-aligned Nanosafety Data Interface can advance findability, accessibility and interoperability across physicochemical, bio–nano interaction, human toxicity, omics, ecotoxicological and exposure data.

Nina Jeliazkova
Margarita D. Apostolova
Penny Nymark
Research20 May 2021
Nature Nanotechnology

Volume: 16, P: 644-654
Common variants at 12q15 and 12q24 are associated with infant head circumference

Vincent Jaddoe and colleagues report a genome-wide association study for infant head circumference. They identify variants in SBNO1 and near HMGA2 that are associated with this phenotype.

H Rob Taal
Beate St Pourcain
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 532-538
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Discharge protocol in acute pancreatitis: an international survey and cohort analysis

Rita Nagy
Klementina Ocskay
Péter Hegyi
ResearchOpen Access13 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
Genetic association study of childhood aggression across raters, instruments, and age

Hill F. Ip
Camiel M. van der Laan
Dorret I. Boomsma
ResearchOpen Access30 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-9
Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram and colleagues report a genome-wide association study for intracranial volume and brain volume. They report two loci associated with intracranial volume.

M Arfan Ikram
Myriam Fornage
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 539-544
Wisdom of crowds for robust gene network inference

This analysis comprehensively compares methods for gene regulatory network inference submitted through the DREAM5 challenge. It demonstrates that integration of predictions from multiple methods shows the most robust performance across data sets.

Daniel Marbach
James C Costello
Gustavo Stolovitzky
Research15 Jul 2012
Nature Methods

Volume: 9, P: 796-804
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts

A Rodriguez
J Miettunen
M-R Järvelin
Research16 Oct 2007
International Journal of Obesity

Volume: 32, P: 550-557
Prenatal exposure to maternal obesity leads to hyperactivity in offspring

C Fernandes
H Grayton
A Rodriguez
Correspondence13 Dec 2011
Molecular Psychiatry

Volume: 17, P: 1159-1160
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Diminishing benefits of urban living for children and adolescents’ growth and development

A predictable conserved DNA base composition signature defines human core DNA replication origins

Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Repositioning of the global epicentre of non-optimal cholesterol

Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses

Photochemistry dominates over photothermal effects in the laser-induced reduction of graphene oxide by visible light

Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity

ZSCAN21 mediates the pathogenic transcriptional induction of α-synuclein in cellular and animal models of Parkinson’s disease

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

A mouse model for hereditary thyroid dysgenesis and cleft palate

Analysis of metagenomic data

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Common variation near ROBO2 is associated with expressive vocabulary in infancy

An integrated encyclopedia of DNA elements in the human genome

Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

Interrupted reactions in chemical synthesis

A survey of dental services in England providing targeted care for people experiencing social exclusion: mapping and dimensions of access

Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations

Towards FAIR nanosafety data

Common variants at 12q15 and 12q24 are associated with infant head circumference

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Discharge protocol in acute pancreatitis: an international survey and cohort analysis

Genetic association study of childhood aggression across raters, instruments, and age

Common variants at 6q22 and 17q21 are associated with intracranial volume

Wisdom of crowds for robust gene network inference

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts

Prenatal exposure to maternal obesity leads to hyperactivity in offspring

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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