Nature Search

Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients

Liuyang Zhao
Xiang Zhang
Jun Yu
ResearchOpen Access27 Jul 2022
Oncogene

Volume: 41, P: 4200-4210
The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer

Looking for metabolic-associated vulnerabilities is a promising approach for therapeutic intervention in KRAS-mutant colorectal cancer. Here, the authors show that the cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic target in KRASmutant colorectal cancer.

Chi Chun Wong
Jian-Lin Wu
Jun Yu
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Xiang Zhang
Harry Cheuk-Hay Lau
Jun Yu
Amendments and CorrectionsOpen Access21 Jan 2025
Nature Metabolism

Volume: 7, P: 230
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Intestinal TM6SF2 is found to interact with fatty acid-binding protein 5 to modulate the secretion of fatty acids and the composition of the gut microbiota, thereby protecting against metabolic dysfunction-associated steatohepatitis.

Xiang Zhang
Harry Cheuk-Hay Lau
Jun Yu
ResearchOpen Access08 Jan 2025
Nature Metabolism

Volume: 7, P: 102-119
Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice

Interactions between Peptostreptococcus anaerobius and host cells promote recruitment and activation of myeloid-derived suppressor cells, leading to anti-PD1 immune checkpoint inhibitor resistance and exacerbated colorectal cancer in mice.

Yali Liu
Chi Chun Wong
Jun Yu
ResearchOpen Access15 May 2024
Nature Microbiology

Volume: 9, P: 1467-1482
Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

Alvin Ho-Kwan Cheung
Chit Chow
Ka-Fai To
Research10 May 2018
Laboratory Investigation

Volume: 98, P: 968-976
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma

Yuan and colleagues developed an artificial intelligence-based method to derive growth patterns and morphological features from hematoxylin and eosin-stained slides of lung adenocarcinoma samples, for improved tumor grading and patient prognostication.

Xiaoxi Pan
Khalid AbdulJabbar
David A. Moore
ResearchOpen Access10 Jan 2024
Nature Cancer

Volume: 5, P: 347-363
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5

Alvin Ho-Kwan Cheung
Kit-Yee Wong
Ka-Fai To
ResearchOpen Access05 Jul 2023
Oncogenesis

Volume: 12, P: 1-14

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Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients

The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer

Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice

Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma

MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5

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