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High-throughput discovery of novel developmental phenotypes

Identification and characterization, using a comprehensive embryonic phenotyping pipeline, of 410 lethal alleles during the generation of the first 1,751 of 5,000 unique gene knockouts produced by the International Mouse Phenotyping Consortium.

Mary E. Dickinson
Ann M. Flenniken
Stephen A. Murray
Research14 Sept 2016
Nature

Volume: 537, P: 508-514
Correction: Corrigendum: High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson
Ann M. Flenniken
Maja Bućan Stephen A. Murray
Amendments and Corrections08 Nov 2017
Nature

Volume: 551, P: 398
Identification of genetic elements in metabolism by high-throughput mouse phenotyping

The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

Jan Rozman
Birgit Rathkolb
Martin Hrabe de Angelis
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-16
Biogeochemical and historical drivers of microbial community composition and structure in sediments from Mercer Subglacial Lake, West Antarctica

Christina L. Davis
Ryan A. Venturelli
Bob Zook
ResearchOpen Access30 Jan 2023
ISME Communications

Volume: 3, P: 1-11
Identification of genes required for eye development by high-throughput screening of mouse knockouts

Bret Moore et al. from the International Mouse Phenotyping Consortium report the identification of 347 mouse genes that influence ocular phenotypes when knocked out. 75% of the identified genes have not previously been associated with any ocular pathology.

Bret A. Moore
Brian C. Leonard
Ala Moshiri
ResearchOpen Access21 Dec 2018
Communications Biology

Volume: 1, P: 1-12

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High-throughput discovery of novel developmental phenotypes

Correction: Corrigendum: High-throughput discovery of novel developmental phenotypes

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Biogeochemical and historical drivers of microbial community composition and structure in sediments from Mercer Subglacial Lake, West Antarctica

Identification of genes required for eye development by high-throughput screening of mouse knockouts

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