Nature Search

Hopes, fears and uncertainty: life scientists react to Trump’s election victory

Leading biomedical researchers outline their priorities for the incoming administration.

Amander Clark
Eric Topol
Ramanan Laxminarayan
Comments & Opinion25 Nov 2024
Nature

Volume: 635, P: 812-814
Erratum: MORC1 represses transposable elements in the mouse male germline

William A. Pastor
Hume Stroud
Steven E. Jacobsen
Amendments and Corrections10 Jul 2015
Nature Communications

Volume: 6, P: 1-2
Human embryo implantation modelled in microfluidic channels

An innovative microfluidic device has enabled the modelling of the events that occur in human embryos when they implant in the wall of the uterus. It could be used to help understand early pregnancy loss.

Amander T. Clark
News & Views11 Sept 2019
Nature

Volume: 573, P: 350-351
Derivation of human primordial germ cell-like cells in an embryonic-like culture

Derivation of human primordial germ cell-like cells (hPGCLCs) is critical for reproductive medicine. Here, authors report the induction of hPGCLCs in a bioengineered human pluripotent stem cell culture that mimics peri-implantation human development.

Sajedeh Nasr Esfahani
Yi Zheng
Jianping Fu
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-12
Relationship between nucleosome positioning and DNA methylation

Nucleosomes are composed of around 147 bases of DNA wrapped around an octamer of histone proteins. Here, a genome-wide analysis of nucleosome positioning in Arabidopsis thaliana has been combined with profiles of DNA methylation at single base resolution, revealing 10-base periodicities in the DNA methylation status of nucleosome-bound DNA. The results indicate that nucleosome positioning influences the pattern of DNA methylation throughout the genome.

Ramakrishna K. Chodavarapu
Suhua Feng
Matteo Pellegrini
Research30 May 2010
Nature

Volume: 466, P: 388-392
Functional genetic analysis of mouse chromosome 11

Benjamin T. Kile
Kathryn E. Hentges
Monica J. Justice
Research04 Sept 2003
Nature

Volume: 425, P: 81-86
Fruitful progress to fertility: Male fertility in the test tube

Amander T Clark
Bart T Phillips
Kyle E Orwig
Comments & Opinion06 Dec 2011
Nature Medicine

Volume: 17, P: 1564-1565
Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, and LTR5Hs inactivation abrogates human PGC specification

Xinyu Xiang
Yu Tao
Amander T. Clark
ResearchOpen Access24 Jan 2022
Nature Communications

Volume: 13, P: 1-15
MORC1 represses transposable elements in the mouse male germline

The Microrchidia (Morc) family of GHKL ATPases are important repressors of transposons and other DNA-methylated and silent genes in A. thaliana. Here, the authors show that MORC1 is responsible for repression and methylation of specific classes of transposons in the mouse male germline.

William A. Pastor
Hume Stroud
Steven E. Jacobsen
ResearchOpen Access12 Dec 2014
Nature Communications

Volume: 5, P: 1-14
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation

Chitiashvili et al. report that X-chromosome dosage compensation is achieved via X-chromosome dampening in human female primordial germ cells (hPGCs) and reveal that the lncRNA XACT is a hPGC marker.

Tsotne Chitiashvili
Iris Dror
Amander Clark
Research30 Nov 2020
Nature Cell Biology

Volume: 22, P: 1436-1446
Reprogramming roadmap reveals route to human induced trophoblast stem cells

Single-cell transcriptomics roadmap of human dermal fibroblasts reprogrammed to primed and naive pluripotency reveals a route for the direct reprogramming of somatic cells into induced trophoblast stem cells.

Xiaodong Liu
John F. Ouyang
Jose M. Polo
Research16 Sept 2020
Nature

Volume: 586, P: 101-107
Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

Human fibroblasts are reprogrammed to generate blastocyst-like structures called iBlastoids, which recapitulate aspects of embryo implantation.

Xiaodong Liu
Jia Ping Tan
Jose M. Polo
Research17 Mar 2021
Nature

Volume: 591, P: 627-632
TFAP2C regulates transcription in human naive pluripotency by opening enhancers

Pastor et al. demonstrate a role for TFAP2C in the promotion and maintenance of human naive pluripotency by facilitating the opening of enhancers close to pluripotency factors.

William A. Pastor
Wanlu Liu
Amander T. Clark
Research25 Apr 2018
Nature Cell Biology

Volume: 20, P: 553-564
Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells

Trisomy 12 is the most frequent chromosomal abnormality detected in cultures of human pluripotent stem cells. Here the authors show that human pluripotent stem cells carrying this abnormality exhibit gene expression profiles more similar to those of germ cell tumours, and give rise to more aggressive teratomas.

Uri Ben-David
Gal Arad
Juan Carlos Biancotti
Research08 Sept 2014
Nature Communications

Volume: 5, P: 1-11
Mitochondrial DNA selection in human germ cells

Mitochondria contain their own circular mitochondrial DNA (mtDNA), which, over time, is subjected to mutations that may eventually result in functional defects. A study now describes genetic and metabolic selection processes during germ cell development that prevent accumulation of harmful mtDNA variants.

Di Chen
Amander T. Clark
News & Views25 Jan 2018
Nature Cell Biology

Volume: 20, P: 118-120
Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche

Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque seminiferous tubules, which matures these into late PGCs and spermatogonia-like cells.

Enrique Sosa
Di Chen
Amander T. Clark
ResearchOpen Access17 Dec 2018
Nature Communications

Volume: 9, P: 1-13
The ontogeny of cKIT⁺ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation

Clark and colleagues have characterized the stages during which global epigenetic reprogramming occurs in human primordial germ cells, and delineate the appearance of these changes at 16 days of differentiation.

Sofia Gkountela
Ziwei Li
Amander T. Clark
Research16 Dec 2012
Nature Cell Biology

Volume: 15, P: 113-122
Multiparameter mechanical and morphometric screening of cells

Mahdokht Masaeli
Dewal Gupta
Dino Di Carlo
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-11

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Hopes, fears and uncertainty: life scientists react to Trump’s election victory

Erratum: MORC1 represses transposable elements in the mouse male germline

Human embryo implantation modelled in microfluidic channels

Derivation of human primordial germ cell-like cells in an embryonic-like culture

Relationship between nucleosome positioning and DNA methylation

Functional genetic analysis of mouse chromosome 11

Fruitful progress to fertility: Male fertility in the test tube

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

MORC1 represses transposable elements in the mouse male germline

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

TFAP2C regulates transcription in human naive pluripotency by opening enhancers

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells

Mitochondrial DNA selection in human germ cells

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche

The ontogeny of cKIT⁺ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation

Multiparameter mechanical and morphometric screening of cells

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