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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Natural ecosystems efficiently sequester CO₂, but containing and controlling living systems remains challenging. Here, the authors engineer a photosynthetic living material for dual CO₂ sequestration via biomass accumulation and microbially-induced calcium carbonate precipitation.

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence between cortical regions through amplified WNT signalling.

Nitroxoline is a bacteriostatic quinoline antibiotic, known to form complexes with metals, with few clinical applications. Here, Cacace et al. show that the compound displays a broad activity spectrum, with species-specific bactericidal activity, and acts as a metallophore inducing copper and zinc intoxication in bacterial cells.

Nanocrystals are synthesized with long-term colloidal stability in both polar and non-polar solvents without the need for ligand exchange. During synthesis, conventional coordinating ligands and solvents with long alkyl chains are replaced with those bearing alkoxy repeating units.

The effect of intraspecific body size variation on the efficiency with which energy is transferred between trophic levels is not well understood. Here, Reichstein et al. show that biasing resource delivery toward less efficient consumer life stages can lead to a doubling of consumer biomass.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Phosphate storage in foraminifera is found to be widespread, indicating that these organisms are probably relevant for marine phosphorus cycling and potentially buffer anthropogenic eutrophication in coastal environments.

Superconducting flux qubits operating as two-level systems can act as artificial atoms, and so represent a potential metamaterial building block. Macha et al.assemble 20 such qubits into a metamaterial in which the ‘atoms’ are collectively coupled to the quantized mode of a microwave photon field.

The controllable functionalization of graphene at the molecular level may prove useful for graphene-based electronics, but is difficult to do in a precise fashion. Now it has been shown that a photocycloaddition reaction between a hydrogen-bonded network of maleimide-derived molecules and single-layer graphene can produce a functionalized array with long-range order.

Across many North American forests, recent years with exceptional area burned are not unprecedented when considering the multi-century perspective offered by fire-scarred trees. Nevertheless, abundant evidence suggests that the severity of contemporary wildfire is unprecedented in its adverse impacts on forests and humans.

This study reports a dense, late summer phytoplankton bloom in the Southern Ocean that accumulated unusually high levels of organic matter and supported feeding hot spots for birds and whales. The authors show that this recurring open ocean bloom is driven by anomalies in easterly winds that push sea ice southwards and favour the upwelling of deep waters enriched in hydrothermal iron.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

Biodegradable cellulose-based photonic and plasmonic architectures are fabricated via soft nanoimprinting lithography, and are used for structural colour generation, photoluminescence enhancement and as disposable surface-enhanced Raman scattering substrates.

Using 13 functional traits we characterize the Amazonian trees and the communities they form. Amazonian tree communities are distributed along a fast-slow-spectrum. This results in clear differences in traits among these forests, as well as their biomass and biomass productivity.

DNA from ancient wolves spanning 100,000 years sheds light on wolves’ evolutionary history and the genomic origin of dogs.

The search for biomarkers associated with konzo disease has been a long-standing question within the research community. Here, the authors have uncovered a potential biomarker for konzo that is associated with the ability to manage oxidative damage.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Biological shuttles efficiently traffic molecules in cells, inspiring the development of synthetic analogs. Here, the authors create colloidal shuttles that collect, transport, and deliver cargo particles and cells under the control of external electrical and magnetic fields.

Navigating through everyday environments requires the ability to keep track of others. Here, the authors show this ability is linked to grid-like codes in the human entorhinal cortex that signal the spatial paths other individuals take.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Multi-ancestry genome-wide association analyses and systematic variant-to-gene mapping strategies implicate new genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

A prespecified analysis of the SELECT trial revealed that patients assigned to once-weekly subcutaneous semaglutide 2.4 mg lost significantly more weight than those receiving placebo and showed improvements in various anthropometric indices.

Bruzos et al. analyze >6,800 samples of Cerastoderma edule, generate a reference genome and follow the evolution of bivalve transmissible neoplasia that infects them. They find two lineages that show genomic instability but also long-term tolerance.

How biodiversity is linked to multiple ecosystem functions is not fully understood. Here, the authors show that a new mechanism, which they term the 'jack-of-all-trades' effect, best explains patterns of tree diversity and ecosystem multifunctionality in European forests.

2D nanoporous membranes are predicted to provide highly selective gas transport in combination with extreme permeance. Here authors demonstrate gas separation performance and transport mechanisms through membranes of graphdiyne, a quasi 2D material with a graphene-like structure.

The universality of the trade-off between early growth and lifespan in trees and its implications are disputed. Analysing a global tree ring dataset and performing data-driven simulations, the authors demonstrate the pervasiveness of the trade-off and challenge current earth system models that predict a continuation of the carbon sink into mature forests under warming and increasing CO₂.

The authors present palaeoclimatic data in the form of stable isotope records from equid teeth spanning 12,500 years of human occupation at the site of Ilsenhöhle in Ranis, Germany, including the earliest occupation of the site by Homo sapiens ~45,000 years ago.

Controlling and modulating charge transfer dynamics in composite nanostructures, though promising for optoelectronic applications, remains a challenge. Here, the authors report optical control of charge separation and recombination processes in organic semiconductor-based composite nanostructures.

People often prioritize their own interests, but also like to see themselves as moral. Here the authors show how distortions in memory might resolve this tension by demonstrating that people tend to remember being more generous in the past than they actually were.

A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Cenozoic landscape evolution of southwestern North America remains debated. Here, the authors reconstruct landscape using 4-D numerical models, which can explain extensional collapse and superficial geological record for the Basin and Range Province

A ‘smart’ toilet that uses pressure and motion sensors, biometric identification, urinalysis strips, a computer-vision uroflowmeter and machine learning longitudinally tracks biomarkers of health and disease in the user’s urine and stool.

Extracellular vesicles are naturally occurring nanoparticles that are gaining ground as delivery modalities for therapeutics. Here, the authors conducted a large-scale screening programme to identify potential scaffold proteins for cargo loading into extracellular vesicles.

MAP1B is bound and regulated by fragile X protein FMRP. Here, the authors show that elevated levels of MAP1B reduce the morphological and physiological maturation of human neurons and impair social behavior in mice.

Metal-elastomer nanophases are critical for stretchable electronics but face mixing challenges. This study introduces a kinetic method for precise mixing, yielding gyrified nanophases with improved durability and strain-invariant conductivity, which holds promise for resilient stretchable devices.