Nature Search

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells

A modified fluctuation test applied to colorectal cancer cells shows that EGFR/BRAF inhibitor-induced persisters slowly proliferate and have an increased mutation rate. Error-prone DNA polymerases are identified as potential targets to avoid tumor recurrence following treatment with these drugs.

Mariangela Russo
Simone Pompei
Marco Cosentino Lagomarsino
ResearchOpen Access11 Jul 2022
Nature Genetics

Volume: 54, P: 976-984
Five carbon- and nitrogen-bearing species in a hot giant planet’s atmosphere

The signatures of water, carbon monoxide, hydrogen cyanide, methane, ammonia and acetylene are observed in the transmission spectrum of the hot Jupiter HD 209458b, with abundance ratios suggesting a super-solar carbon-to-oxygen ratio.

Paolo Giacobbe
Matteo Brogi
Andrea Tozzi
Research07 Apr 2021
Nature

Volume: 592, P: 205-208
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia

Epitope engineering of donor haematopoietic stem/progenitor cells endows haematopoietic lineages with selective resistance to CAR T cells or monoclonal antibodies, without affecting protein function or regulation, enabling the targeting of genes that are essential for leukaemia survival and reducing the risk of tumour immune escape.

Gabriele Casirati
Andrea Cosentino
Pietro Genovese
ResearchOpen Access30 Aug 2023
Nature

Volume: 621, P: 404-414
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia

Relapse within acute myeloid leukaemia may be driven by the presence of leukaemia stem cells. Here, the authors use single cell RNA-seq seq to characterise leukemia stem cells, and show miR-126 as a potential marker of resistance.

Matteo Maria Naldini
Gabriele Casirati
Bernhard Gentner
ResearchOpen Access08 Mar 2023
Nature Communications

Volume: 14, P: 1-20
Author Correction: A super-massive Neptune-sized planet

Luca Naponiello
Luigi Mancini
Tiziano Zingales
Amendments and Corrections20 Oct 2023
Nature

Volume: 623, P: E6
A super-massive Neptune-sized planet

Observations of the super-massive Neptune-sized transiting planet TOI-1853 b show a mass almost twice that of any other Neptune-sized planet known so far and a bulk density implying that heavy elements dominate its mass.

Luca Naponiello
Luigi Mancini
Tiziano Zingales
Research30 Aug 2023
Nature

Volume: 622, P: 255-260
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism

Prime editing in hematopoietic cells is improved by engineering nucleotide metabolism.

Sébastien Levesque
Andrea Cosentino
Daniel E. Bauer
Research28 May 2024
Nature Biotechnology

Volume: 43, P: 534-538
Precision treatment of beta-cell monogenic diabetes: a systematic review

Naylor et al. systematically review the efficacy of treatments for beta-cell monogenic diabetes. Limited evidence from the mostly non-randomized, small studies supports no treatment in glucokinase-related hyperglycemia and sulfonylureas for HNF1A-diabetes; further evidence is needed on the optimum treatments in these and other monogenic subtypes.

Rochelle N. Naylor
Kashyap A. Patel
Tiinamaija Tuomi
ResearchOpen Access18 Jul 2024
Communications Medicine

Volume: 4, P: 1-17
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Jair Tenorio
Pablo Alarcón
Pablo Lapunzina
Research04 Nov 2019
European Journal of Human Genetics

Volume: 28, P: 469-479
Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

A. Di Lionardo
G. Di Stefano
Andrea Truini
ResearchOpen Access21 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Transcriptome signatures from discordant sibling pairs reveal changes in peripheral blood immune cell composition in Autism Spectrum Disorder

Michele Filosi
Tony Kam-Thong
Enrico Domenici
ResearchOpen Access14 Apr 2020
Translational Psychiatry

Volume: 10, P: 1-12
Strategies and current practices for penile lengthening in severe Peyronie’s disease cases: a systematic review

Marco Falcone
Mirko Preto
Giulio Garaffa
Reviews03 Sept 2019
International Journal of Impotence Research

Volume: 32, P: 52-63

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A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells

Five carbon- and nitrogen-bearing species in a hot giant planet’s atmosphere

Epitope editing enables targeted immunotherapy of acute myeloid leukaemia

Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia

Author Correction: A super-massive Neptune-sized planet

A super-massive Neptune-sized planet

Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism

Precision treatment of beta-cell monogenic diabetes: a systematic review

Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

Transcriptome signatures from discordant sibling pairs reveal changes in peripheral blood immune cell composition in Autism Spectrum Disorder

Strategies and current practices for penile lengthening in severe Peyronie’s disease cases: a systematic review

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