Nature Search

Species multidimensional effects explain idiosyncratic responses of communities to environmental change

Developing theory to explore the effects of environmental change on the structure of species interactions within communities, the authors show that enhancing asymmetry in the structure can explain idiosyncratic responses to change. They further confirm these findings on experimental data from microbial species grown together compared with in isolation, subject to different temperature regimes.

Andrea Tabi
Frank Pennekamp
Serguei Saavedra
Research22 Jun 2020
Nature Ecology & Evolution

Volume: 4, P: 1036-1043
Direct modulation of Aplysia S-K⁺ channels by a 12-lipoxygenase metabolite of arachidonic acid

Ned Buttner
Steven A. Siegelbaum
Andrea Volterra
Research30 Nov 1989
Nature

Volume: 342, P: 553-555
Immunosuppressive niche engineering at the onset of human colorectal cancer

Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.

Chandler D. Gatenbee
Ann-Marie Baker
Alexander R. A. Anderson
ResearchOpen Access04 Apr 2022
Nature Communications

Volume: 13, P: 1-16
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS

A subpopulation of astrocytes selectively expresses synaptic-like glutamate-release machinery, actively secretes the transmitter and is localized to discrete sites in the hippocampus.

Roberta de Ceglia
Ada Ledonne
Andrea Volterra
ResearchOpen Access06 Sept 2023
Nature

Volume: 622, P: 120-129
Author Correction: Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Sheri Skerget
Daniel Penaherrera
Jonathan J. Keats
Amendments and CorrectionsOpen Access09 Jun 2025
Nature Genetics

P: 1
Cell facilitation promotes growth and survival under drug pressure in breast cancer

In cancer, interactions between treatment-sensitive and resistant cells can influence the effectiveness of therapies. Here, the authors use experimental and mathematical models to explore interactions between ER+ breast cancer cell lineages that are sensitive or resistant to CDK4/6 inhibition, revealing the role of facilitative growth.

Rena Emond
Jason I. Griffiths
Andrea H. Bild
ResearchOpen Access29 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis

Bacterial vaginosis (BV) is typically caused by a shift in the vaginal microbiota from a Lactobacillus-dominant community to one colonised by strains of Gardenerella vaginalis and treatment with the antibiotic metronidazole (MNZ) often results in failure and recurrence. Here, the authors use modelling and in vitro assays to show that sequestration of MNZ by Lactobacillus is critical in reducing efficacy and women with a higher pre-treatment Lactobacillus/Gardnerella ratio are more likely to recur.

Christina Y. Lee
Ryan K. Cheu
Kelly B. Arnold
ResearchOpen Access01 Dec 2020
Nature Communications

Volume: 11, P: 1-12
Competition drives the dispersal dynamics of two cup coral morphs in populations on the Powell Basin slopes, Weddell Sea, Antarctica

Tasnuva Ming Khan
Huw J. Griffiths
Emily G. Mitchell
ResearchOpen Access24 May 2025
Scientific Reports

Volume: 15, P: 1-12
FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons

J. David Sweatt
Andrea Volterra
Eric R. Kandel
Research16 Nov 1989
Nature

Volume: 342, P: 275-278
Astrocyte Ca²⁺ signalling: an unexpected complexity

The role of astrocytic Ca²⁺ signalling in synaptic function remains elusive. In this Opinion article, Volterra and colleagues discuss how recent data reveal an unexpected complexity of Ca²⁺dynamics in astrocytes, which both challenges current thinking and suggests a new conceptual and experimental framework to address astrocyte function.

Andrea Volterra
Nicolas Liaudet
Iaroslav Savtchouk
Reviews17 Apr 2014
Nature Reviews Neuroscience

Volume: 15, P: 327-335
Modulation of microbial community dynamics by spatial partitioning

Computational and experimental analyses of the effects of spatial partitioning in microbial communities identify correlations between biodiversity and spatial context, offering experimental guidance for maintaining microbial community structures.

Feilun Wu
Yuanchi Ha
Lingchong You
Research10 Feb 2022
Nature Chemical Biology

Volume: 18, P: 394-402
A behavioral approach to instability pathways in financial markets

Phenomena like imitation, herding and positive feedbacks in the complex financial markets characterize the emergence of endogenous instabilities, which however is still understudied. Here the authors show that the graph-based approach is helpful to timely recognize phases of increasing instability that can drive the system to a new market configuration.

Alessandro Spelta
Andrea Flori
Fabio Pammolli
ResearchOpen Access06 Apr 2020
Nature Communications

Volume: 11, P: 1-9
Astrocytes as aide-mémoires

Memory formation is known to occur at the level of synaptic contacts between neurons. It therefore comes as a surprise that another type of brain cell, the astrocyte, is also involved in establishing memory.

Mirko Santello
Andrea Volterra
News & Views13 Jan 2010
Nature

Volume: 463, P: 169-170
Metastability demystified — the foundational past, the pragmatic present and the promising future

Metastability is a concept from dynamical systems. In the brain, it is thought to reflect the balance between the cooperative and independent functioning of brain areas or neuronal populations. In this Review, Hancock, Rosas and colleagues provide an overview of metastability in neuroscience.

Fran Hancock
Fernando E. Rosas
Federico E. Turkheimer
Reviews11 Dec 2024
Nature Reviews Neuroscience

Volume: 26, P: 82-100
Glutamate exocytosis from astrocytes controls synaptic strength

Pascal Jourdain
Linda H Bergersen
Andrea Volterra
Research18 Feb 2007
Nature Neuroscience

Volume: 10, P: 331-339
Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate

Paola Bezzi
Vidar Gundersen
Andrea Volterra
Research23 May 2004
Nature Neuroscience

Volume: 7, P: 613-620
Local Ca²⁺ detection and modulation of synaptic release by astrocytes

The authors characterize the endogenous local calcium dynamics in the processes of adult mouse hippocampal astrocytes, and find that the astrocytic Ca²⁺ activity is generated by synaptic events and contributes to basal synaptic transmission reliability.

Maria Amalia Di Castro
Julien Chuquet
Andrea Volterra
Research11 Sept 2011
Nature Neuroscience

Volume: 14, P: 1276-1284
CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

Paola Bezzi
Maria Domercq
Andrea Volterra
Research01 Jul 2001
Nature Neuroscience

Volume: 4, P: 702-710
Age-related epithelial defects limit thymic function and regeneration

Here the authors identify age-associated changes in the epithelial cell compartment of the thymus that form high-density nonproductive microenvironmental niches that contribute toward thymic involution and inhibit its repair following injury.

Anastasia I. Kousa
Lorenz Jahn
Jarrod A. Dudakov
ResearchOpen Access07 Aug 2024
Nature Immunology

Volume: 25, P: 1593-1606
Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Longitudinal genomic and transcriptomic profiling of 1,143 patients with multiple myeloma by the Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study yields an improved copy number and gene expression subtype scheme, most notably a high-risk proliferative subtype associated with complete loss of RB1 or MAX.

Sheri Skerget
Daniel Penaherrera
Jonathan J. Keats
ResearchOpen Access19 Aug 2024
Nature Genetics

Volume: 56, P: 1878-1889
Astrocyte function from information processing to cognition and cognitive impairment

Volterra et al. review evidence that astrocyte-generated signals participate in recruitment and function of neuronal networks underlying memory performance and that signal abnormalities under pathological conditions contribute to cognitive impairment.

Mirko Santello
Nicolas Toni
Andrea Volterra
Reviews21 Jan 2019
Nature Neuroscience

Volume: 22, P: 154-166
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes

Paola Bezzi
Giorgio Carmignoto
Andrea Volterra
Research15 Jan 1998
Nature

Volume: 391, P: 281-285
Reactive astrocyte nomenclature, definitions, and future directions

Good–bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.

Carole Escartin
Elena Galea
Alexei Verkhratsky
Reviews15 Feb 2021
Nature Neuroscience

Volume: 24, P: 312-325
Astrocytes, from brain glue to communication elements: the revolution continues

Andrea Volterra
Jacopo Meldolesi
Reviews15 Jul 2005
Nature Reviews Neuroscience

Volume: 6, P: 626-640
Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability

The authors show that decreased synaptic efficacy onto raphe-projecting lateral habenula neurons supports opiate withdrawal-induced sociability deficits, and they demonstrate a role for TNF-α signaling in this process.

Kristina Valentinova
Anna Tchenio
Manuel Mameli
Research17 Jun 2019
Nature Neuroscience

Volume: 22, P: 1053-1056
OpenFovea: open-source AFM data processing software

Charles Roduit
Bhaskar Saha
Sandor Kasas
Correspondence30 Jul 2012
Nature Methods

Volume: 9, P: 774-775
Ancient mitochondrial diversity reveals population homogeneity in Neolithic Greece and identifies population dynamics along the Danubian expansion axis

Nuno M. Silva
Susanne Kreutzer
Christina Papageorgopoulou
ResearchOpen Access05 Aug 2022
Scientific Reports

Volume: 12, P: 1-15
Lead sulphide colloidal quantum dots for room temperature NO₂ gas sensors

Federica Mitri
Andrea De Iacovo
Lorenzo Colace
ResearchOpen Access28 Jul 2020
Scientific Reports

Volume: 10, P: 1-9
Intrinsic functional connectivity predicts remission on antidepressants: a randomized controlled trial to identify clinically applicable imaging biomarkers

Andrea N. Goldstein-Piekarski
Brooke R. Staveland
Leanne M. Williams
ResearchOpen Access06 Mar 2018
Translational Psychiatry

Volume: 8, P: 1-11
Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder

Mayuresh S. Korgaonkar
Andrea N. Goldstein-Piekarski
Leanne M. Williams
ResearchOpen Access06 Nov 2019
Molecular Psychiatry

Volume: 25, P: 1537-1549
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Species multidimensional effects explain idiosyncratic responses of communities to environmental change

Direct modulation of Aplysia S-K⁺ channels by a 12-lipoxygenase metabolite of arachidonic acid

Immunosuppressive niche engineering at the onset of human colorectal cancer

Specialized astrocytes mediate glutamatergic gliotransmission in the CNS

Author Correction: Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Cell facilitation promotes growth and survival under drug pressure in breast cancer

Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis

Competition drives the dispersal dynamics of two cup coral morphs in populations on the Powell Basin slopes, Weddell Sea, Antarctica

FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons

Astrocyte Ca²⁺ signalling: an unexpected complexity

Modulation of microbial community dynamics by spatial partitioning

A behavioral approach to instability pathways in financial markets

Astrocytes as aide-mémoires

Metastability demystified — the foundational past, the pragmatic present and the promising future

Glutamate exocytosis from astrocytes controls synaptic strength

Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate

Local Ca²⁺ detection and modulation of synaptic release by astrocytes

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

Age-related epithelial defects limit thymic function and regeneration

Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Astrocyte function from information processing to cognition and cognitive impairment

Prostaglandins stimulate calcium-dependent glutamate release in astrocytes

Reactive astrocyte nomenclature, definitions, and future directions

Astrocytes, from brain glue to communication elements: the revolution continues

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability

OpenFovea: open-source AFM data processing software

Ancient mitochondrial diversity reveals population homogeneity in Neolithic Greece and identifies population dynamics along the Danubian expansion axis

Lead sulphide colloidal quantum dots for room temperature NO₂ gas sensors

Intrinsic functional connectivity predicts remission on antidepressants: a randomized controlled trial to identify clinically applicable imaging biomarkers

Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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