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Showing 1–10 of 10 results

Advanced filters: Author: Andreas Beilhack Clear advanced filters

Graft-versus-host disease is enhanced by extracellular ATP activating P2X₇R

By acting on the P2X₇ receptor, ATP released upon cell damage functions as a danger signal to promote acute graft-versus-host disease after bone marrow transplantation in mice.

Konrad Wilhelm
Jayanthi Ganesan
Robert Zeiser
Research21 Nov 2010
Nature Medicine

Volume: 16, P: 1434-1438
Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma

Stefanie Schwinn
Zeinab Mokhtari
Matthias Wölfl
ResearchOpen Access07 Jul 2021
Scientific Reports

Volume: 11, P: 1-15
Brain-to-gut trafficking of alpha-synuclein by CD11c⁺ cells in a mouse model of Parkinson’s disease

Despite being implicated in several neurological diseases, the gut-brain axis remains poorly understood. Here the authors describe a mechanism of communication between the brain and the gut in a Parkinson’s disease mouse model mediated by CD11c⁺ macrophages.

Rhonda L. McFleder
Anastasiia Makhotkina
Chi Wang Ip
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Here authors show that GDF15, a cytokine that is produced by cancer cells, prevents T cells from extravasation into the tumour microenvironment. Low availability of T cells in GDF-15-expressing tumours thus precludes effective immune therapy.

Markus Haake
Beatrice Haack
Jörg Wischhusen
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Transient regulatory T-cell targeting triggers immune control of multiple myeloma and prevents disease progression

Julia Dahlhoff
Hannah Manz
Andreas Beilhack
ResearchOpen Access28 Sept 2021
Leukemia

Volume: 36, P: 790-800
Protein kinase CK2 enables regulatory T cells to suppress excessive T_H2 responses in vivo

The mechanisms that control the suppressive function of T_reg cells in specific tissues are unclear. Bopp and colleagues show that T_reg cells have high expression of kinase CK2 and this is critical for their ability to suppress type 2 responses in the lungs.

Alexander Ulges
Matthias Klein
Tobias Bopp
Research19 Jan 2015
Nature Immunology

Volume: 16, P: 267-275
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

The growth of cancer cells can be stably arrested by cytokine-induced senescence. Here, the authors show that cancers with defects in senescence-inducing cell cycle regulator pathways are resistant to immune checkpoint blockade.

Ellen Brenner
Barbara F. Schörg
Martin Röcken
ResearchOpen Access12 Mar 2020
Nature Communications

Volume: 11, P: 1-19
Thrombopoiesis is spatially regulated by the bone marrow vasculature

Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow.

David Stegner
Judith M. M. vanEeuwijk
Katrin G. Heinze
ResearchOpen Access25 Jul 2017
Nature Communications

Volume: 8, P: 1-11
NFATc1 controls the cytotoxicity of CD8⁺ T cells

NFAT nuclear translocation has been shown to be required for CD8⁺ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8⁺ T cells required for optimal response to bacteria and tumor cells.

Stefan Klein-Hessling
Khalid Muhammad
Edgar Serfling
ResearchOpen Access11 Sept 2017
Nature Communications

Volume: 8, P: 1-15
TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity

Juliane Medler
Johannes Nelke
Harald Wajant
ResearchOpen Access04 Mar 2019
Cell Death & Disease

Volume: 10, P: 1-13