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Showing 151–200 of 288 results

Advanced filters: Author: Andreas Heinz Clear advanced filters

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Gene discovery and polygenic predictions from a genome-wide association study of educational attainment in 1.1 million individuals.

James J. Lee
Robbee Wedow
David Cesarini
Research23 Jul 2018
Nature Genetics

Volume: 50, P: 1112-1121
A protocol for data harmonization in large cohorts

This Comment presents a high-level protocol for data harmonization within large cohorts, in which it postulates four main steps including (1) expert review, (2) pre-statistical harmonization, (3) statistical harmonization, and (4) validation.

Maja Neidhart
Rikka Kjelkenes
George Ogoh
Comments & Opinion01 Oct 2024
Nature Mental Health

Volume: 2, P: 1134-1137
The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults

Hengyi Cao
Anais Harneit
Heike Tost
Research07 Jun 2017
Neuropsychopharmacology

Volume: 43, P: 406-414
Inferring causal molecular networks: empirical assessment through a community-based effort

The HPN-DREAM community challenge assessed the ability of computational methods to infer causal molecular networks, focusing specifically on the task of inferring causal protein signaling networks in cancer cell lines.

Steven M Hill
Laura M Heiser
Sach Mukherjee
ResearchOpen Access22 Feb 2016
Nature Methods

Volume: 13, P: 310-318
Influence of Familial Risk for Depression on Cortico-Limbic Connectivity During Implicit Emotional Processing

Carolin Wackerhagen
Torsten Wüstenberg
Nina Romanczuk-Seiferth
Research15 Mar 2017
Neuropsychopharmacology

Volume: 42, P: 1729-1738
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

Infection with influenza virus can result in bacterial superinfection, but the mechanisms underlying this process are unclear. Bergthaler and colleagues demonstrate that influenza virus upregulates the methyltransferase Setdb2, which attenuates select proinflammatory gene expression and heightens susceptibility to bacterial infection.

Christopher Schliehe
Elizabeth K Flynn
Andreas Bergthaler
Research24 Nov 2014
Nature Immunology

Volume: 16, P: 67-74
Anxiety onset in adolescents: a machine-learning prediction

Alice V. Chavanne
Marie Laure Paillère Martinot
Robert Whelan
ResearchOpen Access08 Dec 2022
Molecular Psychiatry

Volume: 28, P: 639-646
Chronic disease outcome metadata from German observational studies – public availability and FAIR principles

Carolina Schwedhelm
Katharina Nimptsch
Tobias Pischon
ResearchOpen Access05 Dec 2023
Scientific Data

Volume: 10, P: 1-18
Author Correction: Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Amit Sud
Hauke Thomsen
Richard S. Houlston
Amendments and CorrectionsOpen Access08 Jan 2019
Nature Communications

Volume: 10, P: 1-3
Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood

Rocco Marchitelli
Marie-Laure Paillère Martinot
Eric Artiges
Research02 Jul 2024
Molecular Psychiatry

Volume: 29, P: 3769-3778
Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning

Max M. Owens
Matthew D. Albaugh
Gunter Schumann
ResearchOpen Access06 May 2022
Translational Psychiatry

Volume: 12, P: 1-9
Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits

Aet O’Leary
Noèlia Fernàndez-Castillo
Andreas Reif
ResearchOpen Access10 Aug 2022
Molecular Psychiatry

Volume: 27, P: 4464-4473
Towards the sustainable discovery and development of new antibiotics

Antimicrobial resistance is an increasing threat to public health and encouraging the development of new antimicrobials is one of the most important ways to address the problem. This Roadmap article aims to bring together industrial, academic and political partners, and proposes both short-term and long-term solutions to this challenge.

Marcus Miethke
Marco Pieroni
Rolf Müller
Reviews19 Aug 2021
Nature Reviews Chemistry

Volume: 5, P: 726-749
Biomass turnover time in terrestrial ecosystems halved by land use

Biomass turnover time is a key parameter in the global carbon cycle. An analysis of global land-use data reveals that biomass turnover is almost twice as fast when the land is used to enhance terrestrial ecosystem services.

Karl-Heinz Erb
Tamara Fetzel
Helmut Haberl
Research22 Aug 2016
Nature Geoscience

Volume: 9, P: 674-678
Positron spectroscopy of point defects in the skyrmion-lattice compound MnSi

Markus Reiner
Andreas Bauer
Christoph Hugenschmidt
ResearchOpen Access08 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
Large-scale analysis of CDH1 mutations defines a distinctive molecular subset with treatment implications in gastric cancer

Jingyuan Wang
Joanne Xiu
Heinz-Josef Lenz
ResearchOpen Access30 Sept 2024
npj Precision Oncology

Volume: 8, P: 1-10
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E Sønderby
Ómar Gústafsson
Ole A. Andreassen
ResearchOpen Access03 Oct 2018
Molecular Psychiatry

Volume: 25, P: 584-602
Linked patterns of biological and environmental covariation with brain structure in adolescence: a population-based longitudinal study

Amirhossein Modabbernia
Abraham Reichenberg
Sophia Frangou
ResearchOpen Access22 May 2020
Molecular Psychiatry

Volume: 26, P: 4905-4918
Results of German external quality assessment schemes for SARS-CoV-2 antigen detection

Laura Vierbaum
Nathalie Wojtalewicz
Martin Kammel
ResearchOpen Access14 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2

Ronja Wieboldt
Michael Sandholzer
Natalia Rodrigues Mantuano
ResearchOpen Access06 Mar 2024
Cellular & Molecular Immunology

Volume: 21, P: 495-509
Observing crystal nucleation in four dimensions using atomic electron tomography

Atomic electron tomography captures crystal nucleation in four dimensions in FePt nanoparticles, with the observed early-stage nucleation not consistent with classical nucleation theory.

Jihan Zhou
Yongsoo Yang
Jianwei Miao
Research26 Jun 2019
Nature

Volume: 570, P: 500-503
Bridging the phenomenological gap between predictive basic-symptoms and attenuated positive symptoms: a cross-sectional network analysis

Hendrik Müller
Linda T. Betz
Andreas Bechdolf
ResearchOpen Access24 Aug 2022
Schizophrenia

Volume: 8, P: 1-7
Genome-wide association study identifies 74 loci associated with educational attainment

A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a small proportion of the variation in educational attainment, highlights candidate genes and pathways for further study.

Aysu Okbay
Jonathan P. Beauchamp
Daniel J. Benjamin
Research11 May 2016
Nature

Volume: 533, P: 539-542
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

Stéphanie Debette and colleagues report the results of a genome-wide association study of cervical artery dissection, a major cause of ischemic stroke in young adults. They show that common variation in PHACTR1, previously associated with lower risk of migraine and increased risk of myocardial infarction, is associated with reduced risk of cervical artery dissection.

Stéphanie Debette
Yoichiro Kamatani
Jean Dallongeville
Research24 Nov 2014
Nature Genetics

Volume: 47, P: 78-83
In vivo protein crystallization opens new routes in structural biology

Expression of a protein in Sf9 insect cells at high concentration triggers formation of in vivo crystals that can be analyzed by serial femtosecond X-ray crystallography.

Rudolf Koopmann
Karolina Cupelli
Michael Duszenko
Research29 Jan 2012
Nature Methods

Volume: 9, P: 259-262
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Altered glutamatergic neurotransmission can lead to the core symptoms of autism, and ProSAP1/Shank2 and ProSAP2/Shank3 proteins seem to serve different interrelated functions at excitatory synapses, especially in glutamate receptor targeting/assembly.

Michael J. Schmeisser
Elodie Ey
Tobias M. Boeckers
Research29 Apr 2012
Nature

Volume: 486, P: 256-260
Influence of the autotaxin-lysophosphatidic acid axis on cellular function and cytokine expression in different breast cancer cell lines

Theresa Hauck
Sheetal Kadam
Annika Kengelbach-Weigand
ResearchOpen Access01 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
Local electron-electron interaction strength in ferromagnetic nickel determined by spin-polarized positron annihilation

Hubert Ceeh
Josef Andreas Weber
Christoph Hugenschmidt
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-9
Differential predictors for alcohol use in adolescents as a function of familial risk

Mira Tschorn
Robert C. Lorenz
Amir Tahmasebi
ResearchOpen Access04 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11
Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP

Ron D. Jachimowicz
Wolfram Klapper
Andreas Rosenwald
ResearchOpen Access10 Jun 2021
Leukemia

Volume: 35, P: 3589-3593
Sorafenib or placebo in patients with newly diagnosed acute myeloid leukaemia: long-term follow-up of the randomized controlled SORAML trial

Christoph Röllig
Hubert Serve
Gerhard Ehninger
ResearchOpen Access18 Feb 2021
Leukemia

Volume: 35, P: 2517-2525
PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system

Kai Zimmer
Florian Kocher
Andreas Seeber
ResearchOpen Access03 Jul 2023
npj Precision Oncology

Volume: 7, P: 1-9
Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHD

Thomas Dresler
Ann-Christine Ehlis
Andreas J Fallgatter
Research14 Jul 2010
Neuropsychopharmacology

Volume: 35, P: 2193-2202
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

The neuropeptide CRH is believed to induce aversive, stress-like behavioral responses. Here the authors describe a distinct population of CRH neurons in the extended amygdala that act to suppress anxiety by positively modulating dopamine release.

Nina Dedic
Claudia Kühne
Jan M. Deussing
Research21 May 2018
Nature Neuroscience

Volume: 21, P: 803-807
High frequency of simultaneous loss of p16 and p16β gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach

Kazuhiko Hayashi
Ralf Metzger
Peter V Danenberg
Research18 Sept 1997
Oncogene

Volume: 15, P: 1481-1488
The IMAGEN study: a decade of imaging genetics in adolescents

Lea Mascarell Maričić
Henrik Walter
Amir Tahmasebi
ReviewsOpen Access29 Jun 2020
Molecular Psychiatry

Volume: 25, P: 2648-2671
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Richard Trembath and colleagues report a meta-analysis of genome-wide association studies for psoriasis, including 2 cohorts genotyped on the custom Immunochip array, in a total of 10,588 cases and 22,806 controls. They identify 15 new susceptibility loci and refine signals in previously known loci, highlighting a role for innate host defense in susceptibility to psoriasis.

Lam C Tsoi
Sarah L Spain
Richard C Trembath
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1341-1348
Anthropogenic electromagnetic noise disrupts magnetic compass orientation in a migratory bird

For the first time under reproducible and fully double-blinded conditions, it is shown that anthropogenic electromagnetic noise below the WHO limits affects a biological system: night-migrating birds lose the ability to use the Earth’s magnetic field for orientation when exposed to anthropogenic electromagnetic noise at strengths routinely produced by commonly used electronic devices.

Svenja Engels
Nils-Lasse Schneider
Henrik Mouritsen
Research07 May 2014
Nature

Volume: 509, P: 353-356
EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity

Johannes Lorenz Berg
Bianca Perfler
Armin Zebisch
ResearchOpen Access15 Feb 2021
Leukemia

Volume: 35, P: 1521-1526
BRAF^V600E promotes DC3/monocyte differentiation in human gene-engineered HSPCs and causes multisystem histiocytosis

Tommaso Sconocchia
Johannes Foßelteder
Andreas Reinisch
ResearchOpen Access06 Sept 2023
Leukemia

Volume: 37, P: 2292-2296
Identification and characterization of novel filament-forming proteins in cyanobacteria

Benjamin L. Springstein
Christian Woehle
Karina Stucken
ResearchOpen Access05 Feb 2020
Scientific Reports

Volume: 10, P: 1-17
Significant impact of circulating tumour DNA mutations on survival in metastatic breast cancer patients

Axel Muendlein
Kathrin Geiger
Thomas Decker
ResearchOpen Access24 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Bone-related Circulating MicroRNAs miR-29b-3p, miR-550a-3p, and miR-324-3p and their Association to Bone Microstructure and Histomorphometry

Xaver Feichtinger
Christian Muschitz
Roland Kocijan
ResearchOpen Access20 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
Incidental haptic sensations influence judgment of crimes

Michael Schaefer
Lillia Cherkasskiy
John A. Bargh
ResearchOpen Access16 Apr 2018
Scientific Reports

Volume: 8, P: 1-10
Heritability estimates on Hodgkin’s lymphoma: a genomic- versus population-based approach

Hauke Thomsen
Miguel Inacio da Silva Filho
Kari Hemminki
Research17 Sept 2014
European Journal of Human Genetics

Volume: 23, P: 824-830
Symptomatic osteonecrosis as a treatment complication in Hodgkin lymphoma: an analysis of the German Hodgkin Study Group (GHSG)

Sven Borchmann
Horst Müller
Andreas Engert
Research21 Aug 2018
Leukemia

Volume: 33, P: 439-446
Covid-19 pandemic induced traumatizing medical job contents and mental health distortions of physicians working in private practices and in hospitals

Karl-Heinz Ladwig
Hamimatunnisa Johar
Andreas Goette
ResearchOpen Access31 Mar 2023
Scientific Reports

Volume: 13, P: 1-11
Cannabinoid Receptor Antagonists Counteract Sensorimotor Gating Deficits in the Phencyclidine Model of Psychosis

Martina Ballmaier
Marco Bortolato
PierFranco Spano
Research14 Feb 2007
Neuropsychopharmacology

Volume: 32, P: 2098-2107
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examine pleiotropy with other autoimmune disorders.

Jimmy Z Liu
Johannes Roksund Hov
Tom H Karlsen
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 670-675
Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients

Alberto Puccini
Andreas Seeber
Heinz-Josef Lenz
ResearchOpen Access27 Oct 2021
npj Precision Oncology

Volume: 5, P: 1-8

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