Nature Search

Exploring circulating cell-free DNA as a biomarker and as an inducer of AIM2-inflammasome-mediated inflammation in patients with abdominal aortic aneurysm

Susanne Dihlmann
Carolin Kaduk
Andreas S. Peters
ResearchOpen Access20 Jun 2025
Scientific Reports

Volume: 15, P: 1-17
Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis

Schneeberger, Kim, Geesdorf, Rajewsky, Heppner et al. tease IL-12 and IL-23 signaling apart in mouse models and human brain tissue to define a role for oligodendroglial and neuronal IL-12 signaling in neuroimmune crosstalk in Alzheimer’s disease.

Shirin Schneeberger
Seung Joon Kim
Frank L. Heppner
ResearchOpen Access13 Mar 2025
Nature Aging

Volume: 5, P: 622-641
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

Chronic obstructive pulmonary disease is a severe inflammatory lung disease characterized by obstructed airflow from the lungs. Here, Seimetz et al. show that NADPH oxidase subunit 1 (NOXO1) is responsible for peroxynitrite formation from nitric oxide and superoxide and drives the development of smoke-induced emphysema and pulmonary hypertension.

Michael Seimetz
Natascha Sommer
Norbert Weissmann
Research08 Jun 2020
Nature Metabolism

Volume: 2, P: 532-546
ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis

Video microscopy is key in studying cell migration, but accomplishing this in a high-throughput manner is still challenging. Here, the authors present an array microscope that can track the movements of thousands of individual cells simultaneously, and that can be used for drug screening studies.

Zülal Cibir
Jacqueline Hassel
Matthias Gunzer
ResearchOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Analysis of plant metabolites – the baseline-threshold principle

Katja Neubauer
Jenny Bandomir
Kerstin Schmidt
MultimediaOpen Access14 May 2010
Nature Precedings

P: 1
Analysis of plant metabolites – the baseline-threshold principle

Katja Neubauer
Jenny Bandomir
Kerstin Schmidt
MultimediaOpen Access11 May 2010
Nature Precedings

P: 1
Barium nanoparticles enhance efficacy of external beam radiation therapy in a preclinical basal-like mammary cancer mouse model

Jonas Albers
Andrea Markus
Christian Dullin
ResearchOpen Access30 May 2025
Scientific Reports

Volume: 15, P: 1-11
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma

Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.

Aristeidis Papargyriou
Mulham Najajreh
Maximilian Reichert
ResearchOpen Access10 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 836-864
DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

This study uncovers a critical link between DNMT3A-driven CHIP and heart failure and, in particular, it shows that DNMT3A inactivation in monocytes boosts the release of HB-EGF, which activates fibroblasts inducing diffuse fibrosis in the heart.

Mariana Shumliakivska
Guillermo Luxán
Stefanie Dimmeler
ResearchOpen Access19 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Quantum tricritical points in NbFe₂

A thermodynamic study of doped single crystals of NbFe₂ reveals the phase diagram of this system as a function of temperature, magnetic field and Nb doping — which includes an unusual quantum tricritical point.

Sven Friedemann
Will J. Duncan
F. Malte Grosche
Research11 Sept 2017
Nature Physics

Volume: 14, P: 62-67
Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging

Transition paths by which embryonic stem cells commit to different lineages are not well understood. Here, the authors use combined lineage plus 37-dimensional protein information to identify a developmental cell population co-expressing Sox1 and FoxA2.

Geethika Arekatla
Stavroula Skylaki
Timm Schroeder
ResearchOpen Access09 Sept 2024
Nature Communications

Volume: 15, P: 1-16
The janus-kinase inhibitor ruxolitinib in SARS-CoV-2 induced acute respiratory distress syndrome (ARDS)

Andreas Neubauer
Johannes Johow
Thomas Wiesmann
ResearchOpen Access12 Aug 2021
Leukemia

Volume: 35, P: 2917-2923
Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia

Taylor et al. show that tumor cells promote white adipose tissue (WAT) wasting and cachexia by overactivation of Notch1 signaling and retinoic acid production in distant WAT endothelium, which can be therapeutically targeted to inhibit wasting.

Jacqueline Taylor
Leonie Uhl
Andreas Fischer
ResearchOpen Access25 Sept 2023
Nature Cancer

Volume: 4, P: 1544-1560
Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Human cytomegalovirus (HCMV) is a ubiquitous pathogen associated with morbidity and mortality in the immunocompromised or immunonaive context. Here the authors show that HCMV exploits STING signalling and subverts the interferon response to support infection of monocyte derive dendritic cells.

Bibiana Costa
Jennifer Becker
Ulrich Kalinke
ResearchOpen Access26 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Siwei Chen
Bassel W. Abou-Khalil
Samuel F. Berkovic
Research03 Oct 2024
Nature Neuroscience

Volume: 27, P: 1864-1879
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

Infection with influenza virus can result in bacterial superinfection, but the mechanisms underlying this process are unclear. Bergthaler and colleagues demonstrate that influenza virus upregulates the methyltransferase Setdb2, which attenuates select proinflammatory gene expression and heightens susceptibility to bacterial infection.

Christopher Schliehe
Elizabeth K Flynn
Andreas Bergthaler
Research24 Nov 2014
Nature Immunology

Volume: 16, P: 67-74
Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 526
Nominally identical microplastic models differ greatly in their particle-cell interactions

Microplastics research is often based on commercial model particles. Here, the authors show that nominally identical particles may differ significantly in their properties and thus in their interactions with cells.

Simon Wieland
Anja F. R. M. Ramsperger
Holger Kress
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 282-291
A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

A method called vessel isolation and nuclei extraction for sequencing (VINE-seq) produces a molecular map of vascular and perivascular cell types in the human brain and reveals their contributions to Alzheimer’s disease risk.

Andrew C. Yang
Ryan T. Vest
Tony Wyss-Coray
Research14 Feb 2022
Nature

Volume: 603, P: 885-892
Staphylococcus epidermidis clones express Staphylococcus aureus-type wall teichoic acid to shift from a commensal to pathogen lifestyle

The presence of an accessory genetic element, tarIJLM—which leads to the production of a S. aureus-type wall teichoic acid—alters the lifestyle of S. epidermidis invasive clones, impairing in vivo mouse colonization but increasing endothelial attachment and host mortality.

Xin Du
Jesper Larsen
Andreas Peschel
Research24 May 2021
Nature Microbiology

Volume: 6, P: 757-768
Discovery of a sushi ___domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients

Kai Bartkowiak
Parinaz Mossahebi Mohammadi
Klaus Pantel
ResearchOpen Access31 Jan 2025
Scientific Reports

Volume: 15, P: 1-18
Staphylococcus aureus thermonuclease NucA is a key virulence factor in septic arthritis

Thermonuclease (NucA) in Staphylococcus aureus plays a crucial role in bone erosion in a hematogenous septic arthritis mouse model, as confirmed by increased immune stimulation and enhanced survival in host cells in vitro.

Ningna Li
Meghshree Vinod Deshmukh
Friedrich Götz
ResearchOpen Access10 Apr 2025
Communications Biology

Volume: 8, P: 1-12
Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features

Karpf et al. showed that distinct layers of the adult human and mouse DG are populated by astrocytes, which exhibit a subtype-specific molecular profile and morphology, leading to subtype-specific physiological characteristics.

Julian Karpf
Petr Unichenko
Ruth Beckervordersandforth
Research28 Nov 2022
Nature Neuroscience

Volume: 25, P: 1626-1638
HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids

Complex neuropathologies, like macular degeneration, are common but incompletely understood. Here the authors report a complex human retina pathology organoid model induced by HBEGF-TNF, causing PIEZO1-mediated photoreceptor degeneration by cell extrusion.

Manuela Völkner
Felix Wagner
Mike O. Karl
ResearchOpen Access19 Oct 2022
Nature Communications

Volume: 13, P: 1-22
Exposure modeling of high-frequency electromagnetic fields

Alfred Bürgi
Gaston Theis
Martin Röösli
Research04 Apr 2007
Journal of Exposure Science & Environmental Epidemiology

Volume: 18, P: 183-191
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

Single-cell analysis of COVID-19 patient samples identifies activated immune pathways that correlate with severe disease.

Robert Lorenz Chua
Soeren Lukassen
Roland Eils
Research26 Jun 2020
Nature Biotechnology

Volume: 38, P: 970-979
Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

The mode of miRNA transfer between tumour-immune cells is usually via exosomes. Here, the authors show that an alternative mode of transfer whereby miR-375 from apoptotic tumour cells can be transferred to tumour-associated macrophages via CD36 receptor, which induces macrophage migration and infiltration to the tumours.

Ann-Christin Frank
Stefanie Ebersberger
Bernhard Brüne
ResearchOpen Access08 Mar 2019
Nature Communications

Volume: 10, P: 1-18
Establishment and validation of red fox (Vulpes vulpes) airway epithelial cell cultures at the air-liquid-interface

Andreas W. Oehm
Blandina I. Oliveira Esteves
Manuela Schnyder
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

T. Sunn Pedersen
M. Otte
Sandor Zoletnik
ResearchOpen Access30 Nov 2016
Nature Communications

Volume: 7, P: 1-10
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Here, the authors perform a meta-analysis in 26,699 people with seizures and 492,324 controls to identify 25 genome-wide significant copy-number variants. The discovered loci point to known disease genes and associations with clinical annotations.

Ludovica Montanucci
David Lewis-Smith
Dennis Lal
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells

Andreas Reimer
Aliaksei Vasilevich
Fiona M. Watt
ResearchOpen Access13 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
New-onset IgG autoantibodies in hospitalized patients with COVID-19

Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.

Sarah Esther Chang
Allan Feng
Paul J. Utz
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Quantification of tumor cell invasion using confocal laser scan microscopy

Matthias P. Schönermark
Oliver Bock
Thomas Lenarz
Advertorial01 Oct 1997
Nature Medicine

Volume: 3, P: 1167-1171
Defining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV

Susanne Saussele
Rüdiger Hehlmann
Michael Lauseker
ResearchOpen Access26 Feb 2018
Leukemia

Volume: 32, P: 1222-1228
Impact of disease burden on clinical outcomes of AML patients receiving allogeneic hematopoietic cell transplantation: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Iman Abou Dalle
Myriam Labopin
Mohamad Mohty
Research11 Apr 2023
Bone Marrow Transplantation

Volume: 58, P: 784-790
Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells

Andreas Kupz
Saparna Pai
Catherine M. Miller
ResearchOpen Access04 Aug 2020
Scientific Reports

Volume: 10, P: 1-18
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

Marcus Bantscheff
Dirk Eberhard
Gerard Drewes
Research26 Aug 2007
Nature Biotechnology

Volume: 25, P: 1035-1044
A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Tewis Bouwmeester
Angela Bauch
Giulio Superti-Furga
Research25 Jan 2004
Nature Cell Biology

Volume: 6, P: 97-105
Proteome survey reveals modularity of the yeast cell machinery

Anne-Claude Gavin
Patrick Aloy
Giulio Superti-Furga
Research22 Jan 2006
Nature

Volume: 440, P: 631-636
Functional organization of the yeast proteome by systematic analysis of protein complexes

Anne-Claude Gavin
Markus Bösche
Giulio Superti-Furga
Research10 Jan 2002
Nature

Volume: 415, P: 141-147
Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils

This protocol presents a method for single-cell RNA sequencing of tissue-resident murine eosinophils, with a complementary method for CRISPR screening of bone marrow-derived eosinophils.

Costanza Borrelli
Alessandra Gurtner
Andreas E. Moor
Protocols19 Mar 2024
Nature Protocols

Volume: 19, P: 1679-1709
Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia

Jan-Niklas Eckardt
Sebastian Stasik
Christian Thiede
ResearchOpen Access13 Oct 2023
Leukemia

Volume: 37, P: 2395-2403
Hepamine - A Liver Disease Microarray Database, Visualization Platform and Data-Mining Resource

Timo Itzel
Melanie Neubauer
Andreas Teufel
ResearchOpen Access16 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells

Vincent Andreas Vorwerk
Gerrit Wilms
Walter Becker
ResearchOpen Access13 Oct 2024
Scientific Reports

Volume: 14, P: 1-12
Tracking protein function with sodium multi quantum spectroscopy in a 3D-tissue culture based on microcavity arrays

Andreas Neubauer
Cordula Nies
Lothar R. Schad
ResearchOpen Access21 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
A guide to precise measurements of isotope abundance by ESI-Orbitrap MS

Isotope ratio mass spectrometry as described in this protocol can be used to determine natural variation in the abundance of stable isotopes in individual compounds to provide information relevant to metabolism, ecology or climate change.

Kristýna Kantnerová
Nils Kuhlbusch
Cajetan Neubauer
Protocols23 Apr 2024
Nature Protocols

Volume: 19, P: 2435-2466
Thyroid cancer cells in space during the TEXUS-53 sounding rocket mission – The THYROID Project

Sascha Kopp
Marcus Krüger
Daniela Grimm
ResearchOpen Access09 Jul 2018
Scientific Reports

Volume: 8, P: 1-13
A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency

Laura van Diepen
Falk F. R. Buettner
Andreas W. Kuss
Research08 Aug 2018
European Journal of Human Genetics

Volume: 26, P: 1773-1783

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