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Showing 1–5 of 5 results
Advanced filters: Author: Andrew C. Stelzer Clear advanced filters

  • Protein-focused lead-identification strategies may be limited in their ability to identify small molecules that bind to cellular RNAs. Docking small molecules against the structural ensemble substantially improves the docking accuracy of TAR and has led to the identification of six new TAR binders, one of which inhibits HIV-1 replication.

    • Andrew C Stelzer
    • Aaron T Frank
    • Hashim M Al-Hashimi
    Research
    Nature Chemical Biology
    Volume: 7, P: 553-559

  • This paper reports an NMR approach that enables the three-dimensional movement of two linked RNA helices to be followed for a period up to milliseconds. The two helices move in a highly correlated manner, demonstrating both twisting and bending. Results with different liganded conformations demonstrate that the motions of the unstructured RNA maps out positions within the dynamic envelope described by the bound structures.

    • Qi Zhang
    • Andrew C. Stelzer
    • Hashim M. Al-Hashimi
    Research
    Nature
    Volume: 450, P: 1263-1267

  • Using measurements from 139 global lakes, the authors demonstrate how long-term thermal habitat change in lakes is exacerbated by species’ seasonal and depth-related constraints. They further reveal higher change in tropical lakes, and those with high biodiversity and endemism.

    • Benjamin M. Kraemer
    • Rachel M. Pilla
    • Rita Adrian
    ResearchOpen Access
    Nature Climate Change
    Volume: 11, P: 521-529