Nature Search

Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Edmond M. Kwan
Sarah W. S. Ng
Alison Y. Zhang
Research27 May 2025
Nature Medicine

P: 1-15
Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, but the connecting pathophysiological mechanisms are incompletely understood. Here the authors identify arylsulfatase A as a NASH-induced hepatokine that inhibits hepatic lysophosphatidylcholine and lysophosphatidic acid secretion, and improves muscle insulin action and systemic glucose homeostasis.

Magdalene K. Montgomery
Jacqueline Bayliss
Matthew J. Watt
ResearchOpen Access10 Mar 2022
Nature Communications

Volume: 13, P: 1-18
Large-scale migration into Britain during the Middle to Late Bronze Age

Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

Nick Patterson
Michael Isakov
David Reich
Research22 Dec 2021
Nature

Volume: 601, P: 588-594
MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

James Kramer
Carlos A. Obejero-Paz
Arthur M. Brown
ResearchOpen Access01 Jul 2013
Scientific Reports

Volume: 3, P: 1-7
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming.

Emily Golden
Rabab Rashwan
Pilar Blancafort
ResearchOpen Access26 Mar 2021
Nature Communications

Volume: 12, P: 1-22
Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a subset of non-dividing pre-LSCs maintained by p21.

Cedric S. Tremblay
Jesslyn Saw
David J. Curtis
ResearchOpen Access30 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Ancient dental calculus reveals oral microbiome shifts associated with lifestyle and disease in Great Britain

DNA analysis of ancient dental calculus samples revealed distinct oral microbial communities, including the archaeon Methanobrevibacter, which was associated with hygiene, diet and health.

Abigail S. Gancz
Andrew G. Farrer
Laura S. Weyrich
Research29 Nov 2023
Nature Microbiology

Volume: 8, P: 2315-2325
Conditional expression and signaling of a specifically designed G_i-coupled receptor in transgenic mice

Charles H. Redfern
Peter Coward
Bruce R. Conklin
Research01 Feb 1999
Nature Biotechnology

Volume: 17, P: 165-169
Acute effect of high-intensity interval aerobic exercise on serum myokine levels and resulting tumour-suppressive effect in trained patients with advanced prostate cancer

Jin-Soo Kim
Dennis R. Taaffe
Robert U. Newton
Research29 Nov 2022
Prostate Cancer and Prostatic Diseases

Volume: 26, P: 795-801
Publisher Correction: Reporting guideline for the early-stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI

Baptiste Vasey
Myura Nagendran
Zane B. Perkins
Amendments and Corrections12 Aug 2022
Nature Medicine

Volume: 28, P: 2218
Cardiac rehabilitation and secondary prevention of CVD: time to think about cardiovascular health rather than rehabilitation

Julie Redfern
Robyn Gallagher
Sherry L. Grace
ReviewsOpen Access30 Sept 2024
npj Cardiovascular Health

Volume: 1, P: 1-6
Reporting guideline for the early-stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI

The DECIDE-AI checklist, resulting from a multi-stakeholder group of experts in a Delphi process and following the EQUATOR Network’s recommendations, includes key items that should be reported in early-stage clinical studies of AI-based decision support systems, to ensure a responsible and transparent deployment of AI systems in healthcare.

Baptiste Vasey
Myura Nagendran
Zane B. Perkins
Reviews18 May 2022
Nature Medicine

Volume: 28, P: 924-933
Improving the accuracy of blood pressure measuring devices in Australia: a modelled return on investment study

Zachary Desson
James E. Sharman
Shanthi Ramanathan
ResearchOpen Access08 Nov 2023
Journal of Human Hypertension

Volume: 38, P: 177-186
Controversies around epithelial–mesenchymal plasticity in cancer metastasis

In this Perspectives article, the authors outline the preclinical and clinical evidence for epithelial–mesenchymal plasticity (EMP) in cancer progression and metastasis, focusing on recent challenges and controversies, and highlight strategies to therapeutically target the EMP process.

Elizabeth D. Williams
Dingcheng Gao
Erik W. Thompson
Reviews30 Oct 2019
Nature Reviews Cancer

Volume: 19, P: 716-732
Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer

Ciara Duffy
Anabel Sorolla
Pilar Blancafort
ResearchOpen Access01 Sept 2020
npj Precision Oncology

Volume: 4, P: 1-16
4-dimensional functional profiling in the convulsant-treated larval zebrafish brain

Matthew J. Winter
Dylan Windell
Charles R. Tyler
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-16
Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain

Matthew J. Winter
Dylan Windell
Charles R. Tyler
Amendments and CorrectionsOpen Access23 Oct 2018
Scientific Reports

Volume: 8, P: 1-5
Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics

Anabel Sorolla
Edina Wang
Pilar Blancafort
ReviewsOpen Access21 Oct 2019
Oncogene

Volume: 39, P: 1167-1184

Search

Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

Large-scale migration into Britain during the Middle to Late Bronze Age

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Ancient dental calculus reveals oral microbiome shifts associated with lifestyle and disease in Great Britain

Conditional expression and signaling of a specifically designed G_i-coupled receptor in transgenic mice

Acute effect of high-intensity interval aerobic exercise on serum myokine levels and resulting tumour-suppressive effect in trained patients with advanced prostate cancer

Publisher Correction: Reporting guideline for the early-stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI

Cardiac rehabilitation and secondary prevention of CVD: time to think about cardiovascular health rather than rehabilitation

Reporting guideline for the early-stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI

Improving the accuracy of blood pressure measuring devices in Australia: a modelled return on investment study

Controversies around epithelial–mesenchymal plasticity in cancer metastasis

Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer

4-dimensional functional profiling in the convulsant-treated larval zebrafish brain

Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain

Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics

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