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Showing 1–7 of 7 results
Advanced filters: Author: Angqi Zhu Clear advanced filters

  • Thyroid hormones are crucial for metabolism and development. Here, authors resolve the cryo-EM structure of MCT8, a key transporter for thyroid hormones, revealing how it interacts with substrates and inhibitors. These insights may guide future treatments for thyroid-related diseases.

    • Jiaxin Tan
    • Yuan Xiao
    • Chuangye Yan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • Cryo-EM structures of apo-FKS1 and the FKS1-Rho1 complex reveal how Rho1 activates FKS1, driving conformational changes of FKS1 in β−1,3- glucan synthesis.

    • Jialu Li
    • Huayi Liu
    • Xiang Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Zhu et al. report four cryogenic electron microscopy structures of γ-aminobutyric acid transporter 1 at 2.2–3.2 Å in inward-occluded or inward-open conformations, and elucidate the molecular basis for γ-aminobutyric acid recognition and mode of action of two inhibitors, nipecotic acid and tiagabine.

    • Angqi Zhu
    • Junhao Huang
    • Chuangye Yan
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1012-1022

  • Small solute carriers remain difficult to study by single particle cryo-EM. Here, the authors report the cryo-EM structure of human insulin-responsive glucose transporter GLUT4 (55 kDa) without rigid soluble domains or binders.

    • Yafei Yuan
    • Fang Kong
    • Chuangye Yan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8