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TOF_IMS mass spectrometry-based immunopeptidomics refines tumor antigen identification

MS-based immunopeptidomics provides direct evidence for HLA peptide-antigen presentation, which is indispensable for therapeutic use. Here the authors present an ion mobility MS-based immunopeptidome workflow, largely expand benign reference databases and enables next generation tumor antigen discovery.

Naomi Hoenisch Gravel
Annika Nelde
Juliane S. Walz
ResearchOpen Access17 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

Through injection of human Alzheimer's disease (AD) brain extracts containing pathological tau protein into transgenic mouse lines harboring different levels of amyloid plaque burden, the authors find that the presence of amyloid plaques modifies endogenous pools of tau protein, creating a unique environment required for the seeding and spreading of distinct tau pathologies.

Zhuohao He
Jing L Guo
Virginia M-Y Lee
Research04 Dec 2017
Nature Medicine

Volume: 24, P: 29-38
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Mathias Gorski
Peter J. van der Most
Christian Fuchsberger
ResearchOpen Access28 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Comprehensive mapping of neurotransmitter networks by MALDI–MS imaging

Mass spectrometry imaging with fluoromethylpyridinium-based reactive matrices allows mapping of neurotransmitters at high resolution and at a low limit of detection. The approach is applied to rat, macaque and human brain tissue samples for probing Parkinson’s disease-related changes.

Mohammadreza Shariatgorji
Anna Nilsson
Per E. Andrén
Research23 Sept 2019
Nature Methods

Volume: 16, P: 1021-1028
The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner

Anna-Lena Meinhardt
Enkhtsetseg Munkhbaatar
Philipp J. Jost
ResearchOpen Access29 Jan 2022
Oncogene

Volume: 41, P: 1376-1382
Correction: Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Mathias Gorski
Peter J. van der Most
Christian Fuchsberger
Amendments and CorrectionsOpen Access26 May 2017
Scientific Reports

Volume: 7, P: 1

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TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Comprehensive mapping of neurotransmitter networks by MALDI–MS imaging

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner

Correction: Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

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TOF_IMS mass spectrometry-based immunopeptidomics refines tumor antigen identification