FAPP2 is a key component of the glycosphingolipid synthetic pathway, mediating non-vesicular transport of glucosylceramide from its site of synthesis at the cis-Golgi to the trans-Golgi for conversion into complex glycosphingolipids. FAPP2 therefore has an important role in determining the lipid composition of the plasma membrane, which is highly enriched in glycosphingolipids.
- Giovanni D’Angelo
- Elena Polishchuk
- Maria Antonietta De Matteis
