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Showing 1–2 of 2 results
Advanced filters: Author: Anna Scuto Clear advanced filters

  • NK-cell and γδ-T cell lymphoma share clinic-pathological features; however the driving mutations are largely unknown. Here the authors, using a combination of RNA-Seq analysis, targeted re-sequencing and functional analysis, identify frequent activating mutations in STAT3 and STAT5Bthat may be driver mutations in these diseases.

    • Can Küçük
    • Bei Jiang
    • Wing C. Chan
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • Tumors generate microenvironments that actively suppress the body's anti-tumor immune response. Kortylewski et al. restore immunity by delivering an siRNA against Stat3, a regulator of immune suppression, to myeloid and B cells using a CpG oligonucleotide that targets toll-like receptor 9.

    • Marcin Kortylewski
    • Piotr Swiderski
    • Hua Yu
    Research
    Nature Biotechnology
    Volume: 27, P: 925-932