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Showing 1–12 of 12 results
Advanced filters: Author: Anna Wilbrey-Clark Clear advanced filters

  • The study provides a comprehensive transcriptomic atlas of the human gastrointestinal tract across the lifespan, highlighting inflammation-induced changes in epithelial stem cells that alter mucosal architecture and promote further inflammation.

    • Amanda J. Oliver
    • Ni Huang
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature
    Volume: 635, P: 699-707

  • A human SARS-CoV-2 challenge study in individuals without previous exposure to the virus or vaccines provides detailed profiles of local and systemic epithelial and immune cell response dynamics over time and infection status.

    • Rik G. H. Lindeboom
    • Kaylee B. Worlock
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature
    Volume: 631, P: 189-198

  • Single-cell and spatial transcriptomic analysis of eight human heart tissues reveals the cellular profiles and tissue architecture of niches including the cardiac conduction system, and a new tool, drug2cell, identifies drug target expression.

    • Kazumasa Kanemaru
    • James Cranley
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature
    Volume: 619, P: 801-810

  • Multi-omics profiling of 45 human lung samples highlights 80 different cell types along the proximal to distal axis of the lung with certain cell types showing enrichment for disease-associated genes. An immune niche for IgA-expressing plasma cells within airway submucosal glands (SMG) is also identified.

    • Elo Madissoon
    • Amanda J. Oliver
    • Kerstin B. Meyer
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 66-77

  • Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.

    • Matthew D. Young
    • Thomas J. Mitchell
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, with distinct immunomodulatory profiles that regulate the environment necessary for successful placentation.

    • Roser Vento-Tormo
    • Mirjana Efremova
    • Sarah A. Teichmann
    Research
    Nature
    Volume: 563, P: 347-353

  • A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

    • Lisa Sikkema
    • Ciro Ramírez-Suástegui
    • Fabian J. Theis
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1563-1577

  • Single-cell and spatial transcriptomic profiling of the human endometrium highlights pathways governing the proliferative and secretory phases of the menstrual cycle. Analyses of endometrial organoids show that WNT and NOTCH signaling modulate differentiation into the secretory and ciliated epithelial lineages, respectively.

    • Luz Garcia-Alonso
    • Louis-François Handfield
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Genetics
    Volume: 53, P: 1698-1711