c-Myc acts as oncogen in many tumours, often due to its amplification and/or overexpression. This study investigates whether inhibition of endogenous Myc in tumours driven by other oncogenes may also interfere with tumour growth. This was found to be the case. Although systemic inhibition of Myc has effects in other tissues, these were found to be reversible, suggesting that Myc might be a valid anti-cancer target.
- Laura Soucek
- Jonathan Whitfield
- Gerard I. Evan
