Shen et al. identify a noncanonical role for the inflammasome protein NLR family CARD ___domain-containing protein 4 (NLRC4) to attenuate tumor development. NLRC4 forms a scaffold to assemble the ataxia telangiectasia and Rad3-related DNA repair complex and the repair kinase checkpoint kinase-1 to promote repair of DNA breaks.
- Cheng Shen
- Abhimanu Pandey
- Si Ming Man
