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Showing 1–6 of 6 results
Advanced filters: Author: Archa Fox Clear advanced filters

  • Telomere maintenance by telomerase depends on the correct assembly and the recruitment of the enzyme complex. Here, the authors reveal that the RNA/DNA binding proteins NONO, SFPQ, and PSPC1 interact with telomerase via the hTR RNA template, facilitating telomerase trafficking out of Cajal bodies and recruitment to the telomere.

    • Alexander P. Sobinoff
    • Jadon K. Wells
    • Hilda A. Pickett
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Paraspeckles are nuclear bodies built on the long noncoding RNA, NEAT1, that regulate cellular homeostasis, but how they sense and help under stress is unclear. A study now shows mitochondrial stress modulates paraspeckles by altering NEAT1 expression with a feedback loop that influences mitochondrial homeostasis.

    • Archa H. Fox
    News & Views
    Nature Cell Biology
    Volume: 20, P: 1108-1109

  • The role of mutations within long noncoding RNAs (lncRNAs) exons on tumour cell fitness remains to be explored. Here, the authors investigate the landscape of driver lncRNAs in primary and metastatic samples and validate the functional significance of single nucleotide variants in the NEAT1 oncogene in vitro and in vivo.

    • Roberta Esposito
    • Andrés Lanzós
    • Rory Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • In a breast cancer cell line migrating through microchannels, stress-responsive paraspeckle numbers increase under confinement and polarize towards the leading edge.

    • Vanja Todorovski
    • Finn McCluggage
    • Yu Suk Choi
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-6

  • While prostate cancer predominantly exhibits androgen dependence, oestrogen receptor (ER) signalling is also involved. Here, Chakravarty et al.show that ERα regulates the expression of the NEAT1 long non-coding RNA, which in turn promotes tumorigenesis by maintaining an oncogenic programme/cascade.

    • Dimple Chakravarty
    • Andrea Sboner
    • Mark A. Rubin
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-16