Colorectal cancer (CRC) is stratified into four consensus molecular subtypes (CMS1-4) but their distinct molecular profiles remain to be understood. Here the authors model the CRC subtypes with genetically engineered mouse organoids, identify the metabolic signature of CMS3 is driven by enterocyte-like differentiation and it could be targeted by inhibition of carbamoyl-phosphate synthase 1.
- Arezo Torang
- Aleksandar B. Kirov
- Jan Paul Medema
