Nature Search

Cathepsin B promotes Aβ proteotoxicity by modulating aging regulating mechanisms

Neurodegenerative diseases can be exacerbated by excess protease activity by unknown mechanisms. Here, Siddiqui et al. find that in worms, cpr-6 knockdown mitigates the toxicity of the Alzheimer’s-causing Aβ peptide by modulating aging-regulating pathways, thereby enhancing proteostasis.

Atif Ahmed Siddiqui
Emmanuelle Merquiol
Ehud Cohen
ResearchOpen Access03 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Moringa dried leaf extract as bio-foliar fertilizer for revitalizing performance and nutritional status of soybean

Sohail Irshad
Amar Matloob
Shahbaz Khan
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Design of parallel cascade controller for nonlinear continuous stirred tank reactor

Mohammad Atif Siddiqui
ResearchOpen Access20 Feb 2025
Scientific Reports

Volume: 15, P: 1-19
The killifish germline regulates longevity and somatic repair in a sex-specific manner

Moses, Atlan et al. profile the killifish (Nothobranchius furzeri) gonad using single-cell sequencing and reveal that genetic germline depletion induces sexually dimorphic phenotypes, enhancing lifespan in male fish and somatic repair in females.

Eitan Moses
Tehila Atlan
Itamar Harel
Research15 May 2024
Nature Aging

Volume: 4, P: 791-813
Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction

Metabolic reprogramming during Dietary Restriction (DR) activates cytoprotective gene expression. Here the authors show that PUFAs generated during DR signal via the p38-MAPK pathway to enhance cytoprotective gene expression, contributing to increased longevity.

Manish Chamoli
Anita Goyala
Arnab Mukhopadhyay
ResearchOpen Access25 Sept 2020
Nature Communications

Volume: 11, P: 1-13
Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity

Alternative splicing coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here, the authors provide evidence that AS-NMD is enhanced during dietary restriction (DR) and is required for DR-mediated longevity assurance in C. elegans.

Syed Shamsh Tabrez
Ravi Datta Sharma
Arnab Mukhopadhyay
ResearchOpen Access21 Aug 2017
Nature Communications

Volume: 8, P: 1-13
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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