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Immunological imprinting of humoral immunity to SARS-CoV-2 in children

The immune responses to SARS CoV-2 infection in children are less well understood than in adults. Here the authors characterise immune responses to newer omicron lineages and relate these to previous infection with earlier lineages of SARS-CoV-2, implicating a reduced immunogenicity from omicron variants and imprinting from previous virus strains.

Alexander C. Dowell
Tara Lancaster
Paul Moss
ResearchOpen Access29 Jun 2023
Nature Communications

Volume: 14, P: 1-9
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Older people have suboptimal responses to primary series vaccines, which can place them at risk for adverse coronavirus disease 2019 outcomes. Here the authors show that booster vaccines provide a substantial increase in antibody levels in the short term but that there is significant waning 100 d after booster shots.

Gokhan Tut
Tara Lancaster
Paul Moss
ResearchOpen Access20 Jan 2023
Nature Aging

Volume: 3, P: 93-104
Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection

This study shows that during the first wave of SARS-CoV-2 infection in England, residents of long-term care facilities who survived infection developed a robust and stable immunity against the virus that did not negatively impact responses to other seasonal viruses.

Gokhan Tut
Tara Lancaster
Paul Moss
ResearchOpen Access30 May 2022
Nature Aging

Volume: 2, P: 536-547

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Immunological imprinting of humoral immunity to SARS-CoV-2 in children

Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection

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