Nature Search

A new route to rejuvenation

Embryonic stem cells are prized for their ability to mature into all the specialized adult cell types. It may now be possible to reprogramme adult body cells to have the characteristics of stem cells.

M. Azim Surani
Anne McLaren
News & Views20 Sept 2006
Nature

Volume: 443, P: 284-285
Agouti germ line gets acquisitive

Rosalind M John
M Azim Surani
News & Views01 Nov 1999
Nature Genetics

Volume: 23, P: 254-256
Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

X-chromosome inactivation is reversed in the mouse inner cell mass (ICM) through a mechanism that is not fully understood. Here, the authors investigate this process and characterize the contributions of the epigenetic landscape and transcription factors in X-linked gene reactivation dynamics.

Maud Borensztein
Ikuhiro Okamoto
Edith Heard
ResearchOpen Access03 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Genomic imprinting: the emergence of an epigenetic paradigm

Genomic imprinting has provided insights into epigenetic principles that apply in many contexts. This Timeline highlights lessons for developmental gene regulation by looking back at the emergence of our understanding of imprinting, particularly in mammals, and commenting on current questions and recent progress.

Anne C. Ferguson-Smith
Reviews18 Jul 2011
Nature Reviews Genetics

Volume: 12, P: 565-575
Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

Single-cell RNA sequencing of preimplantation mouse embryos demonstrates that lack of paternal Xist leads to genome-wide transcriptional misregulation in the early blastocyst and a failure to activate the extraembryonic pathway.

Maud Borensztein
Laurène Syx
Edith Heard
Research30 Jan 2017
Nature Structural & Molecular Biology

Volume: 24, P: 226-233
A role for Lin28 in primordial germ-cell development and germ-cell malignancy

In order to investigate the earliest molecular mechanisms of germ cell specification, mouse embryonic stem cells were differentiated into putative primordial germ cells (PGCs) in vitro. The use of inhibitory RNAs to then screen candidate genes for effects on the development of these cells demonstrates a genetic pathway for PGC specification involving Lin28, a negative regulator of let-7 microRNA processing.

Jason A. West
Srinivas R. Viswanathan
George Q. Daley
Research05 Jul 2009
Nature

Volume: 460, P: 909-913
220-plex microRNA expression profile of a single cell

Fuchou Tang
Petra Hajkova
M Azim Surani
Protocols07 Sept 2006
Nature Protocols

Volume: 1, P: 1154-1159
Development and applications of single-cell transcriptome analysis

Fuchou Tang
Kaiqin Lao
M Azim Surani
Reviews30 Mar 2011
Nature Methods

Volume: 8, P: S6-S11
Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

Floros et al. show that mtDNA copy number is reduced and non-synonymous mtDNA mutations are eliminated to prevent mtDNA mutation accumulation in germ cells during human primordial germ cell development.

Vasileios I. Floros
Angela Pyle
Patrick F. Chinnery
Research15 Jan 2018
Nature Cell Biology

Volume: 20, P: 144-151
Human primordial germ cell-like cells specified from resetting precursors develop in human hindgut organoids

This protocol describes an efficient method to reconstitute the onset of gametogenesis by co-culturing resetting hPGCLCs with human hindgut organoids, providing a new framework to clarify the physiological and pathological crosstalk between hPGCs and the hindgut.

João Pedro Alves-Lopes
Frederick C. K. Wong
M. Azim Surani
Protocols01 Feb 2024
Nature Protocols

Volume: 19, P: 1149-1182
SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements

Dang Vinh Do
Bernhard Strauss
M. Azim Surani
ResearchOpen Access19 Jun 2018
Cell Discovery

Volume: 4, P: 1-16
Reprogramming of genome function through epigenetic inheritance

M. Azim Surani
ReviewsOpen Access01 Nov 2001
Nature

Volume: 414, P: 122-128
RNA-Seq analysis to capture the transcriptome landscape of a single cell

Fuchou Tang
Catalin Barbacioru
M Azim Surani
Protocols25 Feb 2010
Nature Protocols

Volume: 5, P: 516-535
Epigenetic reprogramming in mouse and human primordial germ cells

Sun-Min Lee
M. Azim Surani
ReviewsOpen Access13 Dec 2024
Experimental & Molecular Medicine

Volume: 56, P: 2578-2587
The unfolding body plan of primate embryos in culture

Jitesh Neupane
Frederick C. K. Wong
M. Azim Surani
Research Highlights08 Jan 2020
Cell Research

Volume: 30, P: 103-104
Staged profiling of sperm development in sync

Navin B. Ramakrishna
M. Azim Surani
Research Highlights14 Sept 2018
Cell Research

Volume: 28, P: 965-966
Derivation of hypermethylated pluripotent embryonic stem cells with high potency

Siqin Bao
Walfred WC Tang
M Azim Surani
ResearchOpen Access27 Oct 2017
Cell Research

Volume: 28, P: 22-34
Uncovering the role of 5-hydroxymethylcytosine in the epigenome

The recent discovery of enzymes that convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) in mammalian genomes has led to a surge of interesting possible functions for 5hmC, from the regulation of DNA methylation to the biology of pluripotency, differentiation and brain function.

Miguel R. Branco
Gabriella Ficz
Wolf Reik
Reviews15 Nov 2011
Nature Reviews Genetics

Volume: 13, P: 7-13
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

The life cycle of an organism is characterized by phases of reprogramming and differentiation during development from the zygote to the adult organism. Lineage-determining transcription factors and epigenetic mechanisms form inseparable strands that regulate pluripotency and early cell lineage decisions.

Myriam Hemberger
Wendy Dean
Wolf Reik
Reviews15 Jul 2009
Nature Reviews Molecular Cell Biology

Volume: 10, P: 526-537
Genomic imprinting: parental influence on the genome

Wolf Reik
Jörn Walter
Reviews01 Jan 2001
Nature Reviews Genetics

Volume: 2, P: 21-32