GTSE1 performs oncogenic functions in various tumors; however, its role in clear cell renal cell carcinoma (ccRCC) remains unknown. Here, the authors found that GTSE1 is overexpressed in ccRCC, and its high expression was positively relation with advanced clinical stages and worse prognosis. In additional, GTSE1 knockdown inhibited ccRCC cell malignant phenotype in vitro and vivo. Mechanistically, GTSE1 promotes ccRCC malignance progression by attenuating KLF4 expression.
- Weihao Chen
- Hanfeng Wang
- Xu Zhang
