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Showing 1–2 of 2 results
Advanced filters: Author: Barbara Hopfgartner Clear advanced filters

  • RNA interference screens were used to identify chromatin-associated factors that impede reprogramming of somatic cells into iPS cells; suppression of the chromatin assembly factor CAF-1 enhances the generation of iPS cells by rendering chromatin more accessible to pluripotency transcription factors.

    • Sihem Cheloufi
    • Ulrich Elling
    • Konrad Hochedlinger
    Research
    Nature
    Volume: 528, P: 218-224

  • BET bromodomain inhibitors are being explored as potential therapeutics in cancer; here, AML cells are shown to evade sensitivity to BET inhibition through rewiring the transcriptional regulation of BRD4 target genes such as MYC in a process that is facilitated by suppression of PRC2 and WNT signalling activation.

    • Philipp Rathert
    • Mareike Roth
    • Johannes Zuber
    Research
    Nature
    Volume: 525, P: 543-547