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Impact of unequal testing on vaccine effectiveness estimates across two study designs: a simulation study

Estimates of effectiveness of SARS-CoV-2 vaccines against symptomatic infection from observational studies may be biased if testing rates differ according to vaccination status. Here, the authors use simulations to quantify the impact of this testing bias in retrospective cohort and test-negative study designs.

Korryn Bodner
Linwei Wang
Sharmistha Mishra
ResearchOpen Access24 May 2025
Nature Communications

Volume: 16, P: 1-15
The structure and oxidation of the eye lens chaperone αA-crystallin

Oligomers of human αA-crystallin are characterized structurally via a hybrid approach, combining cryo-EM, cross-linking/mass spectrometry, NMR and modeling, providing insight into their dynamic behavior and heterogeneity and revealing that oxidized oligomers can also act as chaperones.

Christoph J. O. Kaiser
Carsten Peters
Sevil Weinkauf
Research02 Dec 2019
Nature Structural & Molecular Biology

Volume: 26, P: 1141-1150
Reshaping of the conformational search of a protein by the chaperone trigger factor

The bacterial chaperone named trigger factor is found to stabilize protein folding intermediates that eventually convert to the native state, suggesting that chaperones play a direct role in instructing protein folding.

Alireza Mashaghi
Günter Kramer
Sander J. Tans
Research07 Jul 2013
Nature

Volume: 500, P: 98-101
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting peptides, the authors show evidence of immunoediting in MMR-deficient colorectal and endometrial cancers.

Alexej Ballhausen
Moritz Jakob Przybilla
Matthias Kloor
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-13
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

A study of patients with COVID-19 and healthy donors found CD4⁺ T cells that react to the spike protein of SARS-CoV-2 and human endemic coronaviruses; however, the effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined.

Julian Braun
Lucie Loyal
Andreas Thiel
Research29 Jul 2020
Nature

Volume: 587, P: 270-274
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

SARS-CoV-2-specific CD4⁺ and CD8⁺ T cell epitopes are found in both convalescent patients and virus-naive volunteers and are indicative of heterologous recognition shared with seasonal cold viruses.

Annika Nelde
Tatjana Bilich
Juliane S. Walz
Research30 Sept 2020
Nature Immunology

Volume: 22, P: 74-85
Alternative modes of client binding enable functional plasticity of Hsp70

Hsp70 binds unfolded protein segments in its groove, but can also bind and stabilize folded protein structures, owing to its moveable lid, with ATP hydrolysis and co-chaperones allowing control of these contrasting effects.

Alireza Mashaghi
Sergey Bezrukavnikov
Sander J. Tans
Research26 Oct 2016
Nature

Volume: 539, P: 448-451
Pharmacotherapy vs. minimally invasive therapies as initial therapy for moderate-to-severe benign prostatic hyperplasia: a cost-effectiveness study

Yeva Sahakyan
Aysegul Erman
Dean S. Elterman
Research10 Jun 2022
Prostate Cancer and Prostatic Diseases

Volume: 26, P: 113-118
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autophagy reduces fibroblast activation and ameliorates fibrotic tissue remodeling.

Ariella Zehender
Yi-Nan Li
Jörg H. W. Distler
ResearchOpen Access20 Jul 2021
Nature Communications

Volume: 12, P: 1-19
Precise Slow Oscillation–Spindle Coupling Promotes Memory Consolidation in Younger and Older Adults

Beate E. Muehlroth
Myriam C. Sander
Markus Werkle-Bergner
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation

Beate Hagl
Benedikt D. Spielberger
Ellen D. Renner
ResearchOpen Access13 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Community microattribution review of the evidence for colon cancer risk conferred by constitutional variants in MLH1, MSH2, MSH6 and PMS2 has resulted in the reclassification of two-thirds of the variants reported in existing databases and led to clinical recommendations for the interpretation of 1,370 variants that do not result in obvious protein truncation.

Bryony A Thompson
Amanda B Spurdle
Victor-Manuel Barbera
Research22 Dec 2013
Nature Genetics

Volume: 46, P: 107-115
Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC

Monika Morak
Hans Konrad Schackert
Elke Holinski-Feder
Research27 Feb 2008
European Journal of Human Genetics

Volume: 16, P: 804-811
Homologous sequences at human chromosome 9 bands p12 and q13-21.1 are involved in different patterns of pericentric rearrangements

Heike Starke
Jörg Seidel
Thomas Liehr
Research03 Dec 2002
European Journal of Human Genetics

Volume: 10, P: 790-800
Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET

Franziska C. Trudzinski
Rudolf A. Jörres
Hubert Wirtz
ResearchOpen Access24 May 2022
Scientific Reports

Volume: 12, P: 1-10
Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET

F. C. Trudzinski
R. A. Jörres
Hubert Wirtz
ResearchOpen Access29 Jun 2020
Scientific Reports

Volume: 10, P: 1-11

Search

Impact of unequal testing on vaccine effectiveness estimates across two study designs: a simulation study

The structure and oxidation of the eye lens chaperone αA-crystallin

Reshaping of the conformational search of a protein by the chaperone trigger factor

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Alternative modes of client binding enable functional plasticity of Hsp70

Pharmacotherapy vs. minimally invasive therapies as initial therapy for moderate-to-severe benign prostatic hyperplasia: a cost-effectiveness study

TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

Precise Slow Oscillation–Spindle Coupling Promotes Memory Consolidation in Younger and Older Adults

Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC

Homologous sequences at human chromosome 9 bands p12 and q13-21.1 are involved in different patterns of pericentric rearrangements

Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET

Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET

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