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Author Correction: Ybx1 fine-tunes PRC2 activities to control embryonic brain development

Myron K. Evans
Yurika Matsui
Jamy C. Peng
Amendments and CorrectionsOpen Access25 Jan 2023
Nature Communications

Volume: 14, P: 1
PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression

Here, the authors identify PHF6 as a dependency in SMARCB1-deficient rhabdoid cancers. Mechanistically, this study suggests a regulatory role for PHF6 in recruiting SWI/SNF complexes to enable RNA polymerase progression.

Priya Mittal
Jacquelyn A. Myers
Charles W. M. Roberts
ResearchOpen Access24 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Ybx1 fine-tunes PRC2 activities to control embryonic brain development

Polycomb repressive complex 2 (PRC2) methylates H3K27 and suppresses RNA polymerase II transcription by promoting a closed chromatin. Here the authors identify the transcription factor Ybx1 as an interactor that regulates the binding of PRC2 to chromatin and H3K27 methylation to promote the genetic programs underlying neural lineages and neural progenitor self-renewal–differentiation choices.

Myron K. Evans
Yurika Matsui
Jamy C. Peng
ResearchOpen Access13 Aug 2020
Nature Communications

Volume: 11, P: 1-18
Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1

An interaction between UTX and 53BP1, which occurs in humans but not mice, promotes neurogenic gene expression that underlies neuronal differentiation and cortical development, perhaps providing insight into human-specific neurodevelopment.

Xiaoyang Yang
Beisi Xu
Jamy C. Peng
Research04 Feb 2019
Nature Neuroscience

Volume: 22, P: 362-373
Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens

The role of HOXA9 in binding to noncoding regulatory sequences and regulates the downstream genes in MLL gene rearrangements (MLL-r) leukemia. Here, the use of CRISPR-mediated loss-of-function screen against HOXA9-bound peaks and integrative approaches reveal the noncoding regulation mechanism of HOXA9.

Shaela Wright
Xujie Zhao
Chunliang Li
ResearchOpen Access28 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

KMT2A rearranged infant acute lymphoblastic leukemia patients have a poor prognosis. Here, the authors use high throughput drug screening on primary infant specimens to identify a clinically active chemotherapy combination.

Jennifer L. Kamens
Stephanie Nance
Tanja A. Gruber
ResearchOpen Access13 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia

Different molecular subtypes defined by specific gene rearrangements have been described for acute lymphoblastic leukaemia (ALL). Here, the authors show that ZNF384 fusion activates FLT3 expression conferring a therapeutic vulnerability for ZNF384- rearranged ALL subtype.

Xujie Zhao
Ping Wang
Jun J. Yang
ResearchOpen Access14 Sept 2022
Nature Communications

Volume: 13, P: 1-11
PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors

Histologically, PAX3-FOXO1 (P3F) fusion-positive rhabdomyosarcoma (FP-RMS) resembles muscles cells, however, its cell-of-origin is less clear. Here, the authors demonstrate that P3F expression induces endothelial cells reprogramming into functional myogenic stem cells, driving the formation of FP-RMS in mouse models.

Madeline B. Searcy
Randolph K. Larsen IV
Mark E. Hatley
ResearchOpen Access15 Nov 2023
Nature Communications

Volume: 14, P: 1-23
SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development

The balance of stem cell maintenance, differentiation, and programmed death is critical for proper development. Here they show that SNIP1 is critical for stem cell survival and differentiation in the developing brain where it acts downstream of TGFb and NFkB and regulates PRC2 activities for governing cell fates.

Yurika Matsui
Mohamed Nadhir Djekidel
Jamy C. Peng
ResearchOpen Access08 Aug 2023
Nature Communications

Volume: 14, P: 1-18
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia

The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here, the authors show that IGH-DUX4 translocation occurs on the silenced IGH allele avoiding toxic high-level expression of DUX4 in B-ALL.

Liqing Tian
Ying Shao
Jinghui Zhang
ResearchOpen Access26 Jun 2019
Nature Communications

Volume: 10, P: 1-10
The genetic basis and cell of origin of mixed phenotype acute leukaemia

A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.

Thomas B. Alexander
Zhaohui Gu
Charles G. Mullighan
Research12 Sept 2018
Nature

Volume: 562, P: 373-379
Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

Jennifer L. Kamens
Stephanie Nance
Tanja A. Gruber
Amendments and CorrectionsOpen Access09 Mar 2023
Nature Communications

Volume: 14, P: 1
KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

The histone demethylase KDM6B is reported to be essential for neuroblastoma cell survival. Here the authors show that KDM6B regulates CDK4/6-pRB-E2F pathway through H3K27me3-dependent enhancer-promoter interactions in neuroblastoma.

Alexandra D’Oto
Jie Fang
Jun Yang
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-19
The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy

Myofiber atrophy occurs in many diseases but the mechanisms responsible for myofiber size determination are incompletely understood. Here, the authors show that the muscle-secreted factor Fibcd1 is necessary to maintain myofiber size and mitigates myofiber atrophy induced by cancer cachexia

Flavia A. Graca
Mamta Rai
Fabio Demontis
ResearchOpen Access02 May 2022
Nature Communications

Volume: 13, P: 1-22
MYCN amplification and ATRX mutations are incompatible in neuroblastoma

In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.

Maged Zeineldin
Sara Federico
Michael A. Dyer
ResearchOpen Access14 Feb 2020
Nature Communications

Volume: 11, P: 1-20
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

CRISPR–Cas9 mutagenesis screenings reveal that targeting REGNASE-1 leads to improved therapeutic efficacy of CD8⁺ T cells against mouse models of cancer, and identify BATF as a key target of REGNASE-1.

Jun Wei
Lingyun Long
Hongbo Chi
Research11 Dec 2019
Nature

Volume: 576, P: 471-476
A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function

Intersectional adeno-associated viruses are important for neuroscience research but can be limited by complex and bulky design parameters. Hughes et al. present a unique and space-saving approach that simplifies toolkit development and provides expanded functionality.

Alex C. Hughes
Brittany G. Pittman
Lindsay A. Schwarz
Research27 May 2024
Nature Neuroscience

Volume: 27, P: 1400-1410
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Charles Mullighan, Jinghui Zhang and colleagues characterize a subtype of B-progenitor acute lymphoblastic leukemia with deregulated DUX4 and ERG. They find that aberrant DUX4 activation results in loss of ERG function, either through deletion or by the induction a novel transforming ERG isoform, ERGalt, that inhibits wild-type ERG activity.

Jinghui Zhang
Kelly McCastlain
Charles G Mullighan
Research24 Oct 2016
Nature Genetics

Volume: 48, P: 1481-1489
Metabolic heterogeneity underlies reciprocal fates of T_H17 cell stemness and plasticity

Phenotypically, transcriptionally and metabolically diverse subsets of T_H17 cells develop in a chronic autoimmune disease: one subset has inferred stemness features and low anabolic metabolism, while a reciprocal subset has higher metabolic activity that supports transdifferentiation into T_H1 cells.

Peer W. F. Karmaus
Xiang Chen
Hongbo Chi
Research19 Dec 2018
Nature

Volume: 565, P: 101-105
Orthotopic patient-derived xenografts of paediatric solid tumours

A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours.

Elizabeth Stewart
Sara M. Federico
Michael A. Dyer
Research30 Aug 2017
Nature

Volume: 549, P: 96-100
Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia

Melvin E. Thomas III
Wenqing Qi
Jeffery M. Klco
ResearchOpen Access07 Mar 2024
Leukemia

Volume: 38, P: 991-1002
Spatiotemporal regulation of cholangiocarcinoma growth and dissemination by peritumoral myofibroblasts in a Vcam1-dependent manner

Cheng Tian
Liyuan Li
Liqin Zhu
ResearchOpen Access24 Feb 2023
Oncogene

Volume: 42, P: 1196-1208
Mouse medulloblastoma driven by CRISPR activation of cellular Myc

BaoHan T. Vo
Jin Ah Kwon
Martine F. Roussel
ResearchOpen Access07 Jun 2018
Scientific Reports

Volume: 8, P: 1-11
Short-term GLP-1 receptor agonist exenatide ameliorates intramyocellular lipid deposition without weight loss in ob/ob mice

Fen Xu
Huanyi Cao
Jianping Weng
Research07 Jan 2020
International Journal of Obesity

Volume: 44, P: 937-947

Search

Author Correction: Ybx1 fine-tunes PRC2 activities to control embryonic brain development

PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression

Ybx1 fine-tunes PRC2 activities to control embryonic brain development

Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1

Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens

Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors

SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development

Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia

The genetic basis and cell of origin of mixed phenotype acute leukaemia

Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy

MYCN amplification and ATRX mutations are incompatible in neuroblastoma

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Metabolic heterogeneity underlies reciprocal fates of T_H17 cell stemness and plasticity

Orthotopic patient-derived xenografts of paediatric solid tumours

Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia

Spatiotemporal regulation of cholangiocarcinoma growth and dissemination by peritumoral myofibroblasts in a Vcam1-dependent manner

Mouse medulloblastoma driven by CRISPR activation of cellular Myc

Short-term GLP-1 receptor agonist exenatide ameliorates intramyocellular lipid deposition without weight loss in ob/ob mice

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