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Showing 1–26 of 26 results
Advanced filters: Author: Benjamin R. Rost Clear advanced filters

  • After spinal cord injury (SCI), cyclic adenosine monophosphate (cAMP) levels drop in the central nervous system. Here, authors show that boosting cAMP and subsequently activating corticospinal neurons led to improved neuronal function and motor recovery in female rats after SCI, highlighting a brainstem rerouting pathway for restoring movement after injury.

    • Beatriz Martínez-Rojas
    • Samuel Martín-Pérez
    • Victoria Moreno-Manzano
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

    • Carolina Roselli
    • Mark D. Chaffin
    • Patrick T. Ellinor
    Research
    Nature Genetics
    Volume: 50, P: 1225-1233

  • Sustained neurotransmission requires recycling of synaptic vesicles, but the proposed mechanisms have been controversial; here a ‘flash-and-freeze’ method for electron microscopy reveals a new ultrafast form of endocytosis that is actin- and dynamin-dependent and occurs within 100 milliseconds of stimulation.

    • Shigeki Watanabe
    • Benjamin R. Rost
    • Erik M. Jorgensen
    Research
    Nature
    Volume: 504, P: 242-247

  • Optogenetic tools enable precise experimental control of the behaviour of cells. Here, the authors introduce a genetically-encoded two-protein system that enables silencing of excitable cells such as neurons and cardiomyocytes using blue light, and demonstrate its utility both in vitro and In vivo.

    • Yinth Andrea Bernal Sierra
    • Benjamin R. Rost
    • Dietmar Schmitz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • The authors developed two subcellular optogenetic tools, pHoenix and lyso-pHoenix, that allow light-driven acidification of synaptic vesicles and lysosomes, respectively. pHoenix was used to control the degree of neurotransmitter uptake into synaptic vesicles, revealing that exocytosis of partially filled vesicles is less efficient than the release of completely filled vesicles.

    • Benjamin R Rost
    • Franziska Schneider
    • Christian Rosenmund
    Research
    Nature Neuroscience
    Volume: 18, P: 1845-1852

  • The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategy

    • Patty Sachamitr
    • Jolene C. Ho
    • Peter B. Dirks
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, alongside changes in the microbiome, in samples from individuals with and without prediabetes reveal insights into inter-individual variability and associations between changes in the microbiome and other factors.

    • Wenyu Zhou
    • M. Reza Sailani
    • Michael Snyder
    ResearchOpen Access
    Nature
    Volume: 569, P: 663-671

  • To date, no Ca2 + -selective channelrhodopsins have been characterized. In this study, Fernandez Lahore et al. report two calcium-permeable channelrhodopsins (CapChR1 and 2) for the photocontrol of calcium signalling in excitable tissue.

    • Rodrigo G. Fernandez Lahore
    • Niccolò P. Pampaloni
    • Peter Hegemann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca2+ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure.

    • Benjamin Gottschalk
    • Christiane Klec
    • Wolfgang F. Graier
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • MICU1 is a regulatory subunit of mitochondrial Ca2+ channels that shields mitochondria from Ca2+ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca2+ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca2+uptake activity.

    • Corina T. Madreiter-Sokolowski
    • Christiane Klec
    • Wolfgang F. Graier
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Ultrastructural analysis of synaptic vesicle recycling reveals that clathrin is not required for the initial rapid step of vesicle recycling by ultrafast endocytosis at the plasma membrane and instead clathrin acts later at an endosome to regenerate synaptic vesicles; however, when ultrafast endocytosis does not occur (for example, in experiments at room temperature rather than physiological temperature), clathrin-mediated endocytosis does happen at the plasma membrane.

    • Shigeki Watanabe
    • Thorsten Trimbuch
    • Erik M. Jorgensen
    Research
    Nature
    Volume: 515, P: 228-233

  • K+ plays an important role in physiology and disease, but the lack of high specificity K+ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K+ concentration in body fluids, cells and specific organelles.

    • Helmut Bischof
    • Markus Rehberg
    • Roland Malli
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • This Review provides a comprehensive overview of presynaptic applications of optogenetic tools, including the associated challenges, current limitations and future directions for this approach.

    • Benjamin R. Rost
    • Jonas Wietek
    • Dietmar Schmitz
    Reviews
    Nature Neuroscience
    Volume: 25, P: 984-998

  • Nitric oxide is a volatile free radical second messenger with a large number of biological effects. Here Eroglu et al. develop genetically encoded fluorescent biosensors for nitric oxide and use them to visualise subcellular nitric oxide dynamics in single cells.

    • Emrah Eroglu
    • Benjamin Gottschalk
    • Roland Malli
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Mass spectrometry (MS) enables identification of modified RNA residues, but high-throughput processing is currently a bottleneck. Here, the authors present a free and open-source database search engine for RNA MS data to facilitate reliable identification of modified RNA sequences.

    • Samuel Wein
    • Byron Andrews
    • Hendrik Weisser
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Koshenov et al. investigate the regulation of basal mitochondrial bioenergetics and find that Ca2+ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The authors identify citrin as a primary regulator of this process and show that manipulation of Ca2+ dynamics can reprogram cellular and mitochondrial metabolism.

    • Zhanat Koshenov
    • Furkan E. Oflaz
    • Wolfgang F. Graier
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15