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Showing 1–5 of 5 results
Advanced filters: Author: Benjamin Swedlund Clear advanced filters

  • A major goal in synthetic development is to build gene regulatory circuits that control patterning. Here the authors discover that elevated cell density dampens SynNotch signaling, enabling the design of density-dependent synNotch patterning circuits where multicellular patterning outcomes are programmed by controlled cell proliferation in time and space.

    • Marco Santorelli
    • Pranav S. Bhamidipati
    • Leonardo Morsut
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Single-cell analysis in a mouse model of skin stretching shows that stretching causes a transient expansion bias in a population of epidermal stem cells, which is associated with chromatin remodelling and changes in transcriptional profiles.

    • Mariaceleste Aragona
    • Alejandro Sifrim
    • Cédric Blanpain
    Research
    Nature
    Volume: 584, P: 268-273

  • Endogenous retroviruses constitute 5–10% of mammalian genome space. This study characterize the bovine ERVK[2-1- LTR] clade showing that its activity varies between individuals as a function of the number of inherited autonomous elements, yet that most de novo insertions are non-autonomous elements lacking functional genes.

    • Lijing Tang
    • Benjamin Swedlund
    • Carole Charlier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • In mouse and human squamous cell carcinoma, loss of function of FAT1 promotes tumour initiation, malignant progression and metastasis through the activation of a hybrid epithelial-to-mesenchymal transition phenotype.

    • Ievgenia Pastushenko
    • Federico Mauri
    • Cédric Blanpain
    Research
    Nature
    Volume: 589, P: 448-455