Nature Search

Investigating the molecular ‘scars’ of PTSD in the human brain

Trauma leaves traces in the brain. A study of alterations in gene regulation in the brains of people with post-traumatic stress disorder offers insights into its biology.

Arturo Marroquin Rivera
Benoit Labonté
News & Views18 Jun 2025
Nature
The Tailtag: A multi-mouse tracking system to measure social dynamics in complex environments

Vincent Coulombe
Arturo Marroquin Rivera
Benoit Labonté
Research22 May 2025
Neuropsychopharmacology

P: 1-10
Correction: Corrigendum: Sex-specific transcriptional signatures in human depression

Benoit Labonté
Olivia Engmann
Eric J Nestler
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 525
Transcriptional dissection of symptomatic profiles across the brain of men and women with depression

Recent research sheds light on sex-specific molecular changes in the brains of MDD patients, but their association with specific symptoms is still uncertain. Here, the authors revealed the existence of gene signatures underlying the expression of distinct symptom domains in the brain of men and women with depression.

Samaneh Mansouri
André M. Pessoni
Benoit Labonté
ResearchOpen Access26 Oct 2023
Nature Communications

Volume: 14, P: 1-14
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex

Researchers identify a transcriptional network engaged in stress-resilient mice that is regulated by a previously unstudied transcription factor, Zfp189, and elucidate molecular mechanisms controlling this network and resilience behavior.

Zachary S. Lorsch
Peter J. Hamilton
Eric J. Nestler
Research19 Aug 2019
Nature Neuroscience

Volume: 22, P: 1413-1423
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

Childhood abuse or neglect alters the hormonal stress response and increases the risk for suicide. Analysis of hippocampal samples from human suicide victims with a history of child abuse indicated changes in the expression of the NC3R1 gene that did not occur in suicide victims with no childhood abuse or in people who died of other causes.

Patrick O McGowan
Aya Sasaki
Michael J Meaney
Research22 Feb 2009
Nature Neuroscience

Volume: 12, P: 342-348
β-catenin mediates stress resilience through Dicer1/microRNA regulation

Here β-catenin, which has been implicated in neurological and psychiatric diseases, including depression, is shown to mediate resilience to chronic stress in mice through induction of Dicer and microRNAs in nucleus accumbens, a key brain reward region.

Caroline Dias
Jian Feng
Eric J. Nestler
Research12 Nov 2014
Nature

Volume: 516, P: 51-55
Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Tie Yuan Zhang
Benoit Labonté
Michael J Meaney
Reviews12 Sept 2012
Neuropsychopharmacology

Volume: 38, P: 111-123
Social stress induces neurovascular pathology promoting depression

Chronic social defeat stress induces loss of protein claudin-5, leading to abnormalities in blood vessel morphology, increased blood brain barrier permeability, infiltration of immune signals and depression-like behaviors.

Caroline Menard
Madeline L. Pfau
Scott J. Russo
Research13 Nov 2017
Nature Neuroscience

Volume: 20, P: 1752-1760
Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Stress resilience is accompanied by broad changes in gene expression. This study shows that estrogen receptor α (ERα) is a key upstream regulator of these changes in the nucleus accumbens, and that overexpression of ERα increases behavioral resilience via a sex-specific transcriptional mechanism.

Zachary S. Lorsch
Yong-Hwee Eddie Loh
Eric J. Nestler
ResearchOpen Access16 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

Comprehensive analysis of epigenetic regulation demonstrates a series of complex, interacting chromatin mechanisms by which chronic exposure to opiates downregulates Bdnf gene transcription in the ventral tegmental area. This regulatory cascade is also shown to play a role in controlling opiate-induced behavioral plasticity.

Ja Wook Koo
Michelle S Mazei-Robison
Eric J Nestler
Research02 Feb 2015
Nature Neuroscience

Volume: 18, P: 415-422
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior

Upregulation of the ATP-dependent ACF chromatin-remodeling complex in the NAc is a necessary and causal component for susceptibility to stress-induced depressive behaviors in mice, and this complex is also shown to be upregulated in the NAc of depressed humans.

HaoSheng Sun
Diane M Damez-Werno
Eric J Nestler
Research21 Sept 2015
Nature Medicine

Volume: 21, P: 1146-1153
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.

Laurence Dion-Albert
Alice Cadoret
Caroline Menard
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-18
Association of red blood cell n-3 polyunsaturated fatty acids with plasma inflammatory biomarkers among the Quebec Cree population

M-È Labonté
É Dewailly
B Lamarche
Research16 Jul 2014
European Journal of Clinical Nutrition

Volume: 68, P: 1042-1047
Gadd45b mediates depressive-like role through DNA demethylation

Benoit Labonté
Yun Ha Jeong
Ja Wook Koo
ResearchOpen Access15 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Sex-specific transcriptional signatures in human depression

Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.

Benoit Labonté
Olivia Engmann
Eric J Nestler
Research21 Aug 2017
Nature Medicine

Volume: 23, P: 1102-1111
Erratum: Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Tie Yuan Zhang
Benoit Labonté
Michael J Meaney
Amendments and Corrections15 Apr 2013
Neuropsychopharmacology

Volume: 38, P: 1140
Regulation of impulsive and aggressive behaviours by a novel lncRNA

Benoit Labonté
Khaled Abdallah
Gustavo Turecki
Research06 Jan 2020
Molecular Psychiatry

Volume: 26, P: 3751-3764
Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster

Kathryn Vaillancourt
Jennie Yang
Gustavo Turecki
Research12 Oct 2020
Molecular Psychiatry

Volume: 26, P: 3134-3151
VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine

Cheng Jiang
Wei-Jye Lin
Stephen R. Salton
Research20 Nov 2018
Neuropsychopharmacology

Volume: 44, P: 971-981
Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons

Hope Kronman
Felix Richter
Eric J. Nestler
ResearchOpen Access06 Jun 2019
Scientific Reports

Volume: 9, P: 1-14
Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

F. Quessy
T. Bittar
B. Labonté
ResearchOpen Access26 May 2021
Scientific Reports

Volume: 11, P: 1-13
Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides

Susana G Torres-Platas
Christa Hercher
Naguib Mechawar
Research03 Aug 2011
Neuropsychopharmacology

Volume: 36, P: 2650-2658
Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition

Ja Wook Koo
Mary Kay Lobo
Eric J Nestler
Research23 May 2014
Neuropsychopharmacology

Volume: 39, P: 2646-2653
Validity and reproducibility of a web-based, self-administered food frequency questionnaire

M-È Labonté
A Cyr
B Lamarche
Research21 Sept 2011
European Journal of Clinical Nutrition

Volume: 66, P: 166-173

Search

Investigating the molecular ‘scars’ of PTSD in the human brain

The Tailtag: A multi-mouse tracking system to measure social dynamics in complex environments

Correction: Corrigendum: Sex-specific transcriptional signatures in human depression

Transcriptional dissection of symptomatic profiles across the brain of men and women with depression

Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

β-catenin mediates stress resilience through Dicer1/microRNA regulation

Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Social stress induces neurovascular pathology promoting depression

Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Association of red blood cell n-3 polyunsaturated fatty acids with plasma inflammatory biomarkers among the Quebec Cree population

Gadd45b mediates depressive-like role through DNA demethylation

Sex-specific transcriptional signatures in human depression

Erratum: Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Regulation of impulsive and aggressive behaviours by a novel lncRNA

Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster

VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine

Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons

Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides

Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition

Validity and reproducibility of a web-based, self-administered food frequency questionnaire

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