Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–28 of 28 results
Advanced filters: Author: Berend Snijder Clear advanced filters
  • In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

    • Nicola Miglino
    • Nora C. Toussaint
    • Andreas Wicki
    ResearchOpen Access
    Nature Medicine
    P: 1-12
  • A single-cell ex vivo screening of repurposable drugs in glioblastoma and machine learning of drug–target networks show that anti-tumor neuroactive drugs converge on the AP-1/BTG pathway, based on which prediction models and experimental in vivo and in silico validation identify the anti-depressant vortioxetine as a potential therapeutic agent.

    • Sohyon Lee
    • Tobias Weiss
    • Berend Snijder
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 3196-3208
  • The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

    • Rebekka Wegmann
    • Ximena Bonilla
    • Alexandre P. A. Theocharides
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Susceptibility to drug treatment or viral infection can vary greatly from one cell to another even in a population of genetically identical cells cultured together, but until now the causes of this heterogeneity had not been investigated. Here, deterministic links are revealed between fundamental cellular features and a cell's population context — for example, whether a cell is localized at the centre or at the periphery of an island of adhering cells.

    • Berend Snijder
    • Raphael Sacher
    • Lucas Pelkmans
    Research
    Nature
    Volume: 461, P: 520-523
  • Personalized treatment for cancer patients relies on the deep characterization of tumor cells from patient biopsies. In this study, functional multi-omics profiling of a pan-cancer cohort of malignant serous effusions (MSE) finds strong coherence between MSE and matched solid tumors, underlining the feasibility and utility of multi-modal MSE-based precision oncology.

    • Rebekka Wegmann
    • Lorenz Bankel
    • Berend Snijder
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21
  • Myelofibrosis is a form of myeloproliferative neoplasm with few treatment options available. Here, the authors profiled drug responses and proteomics ex vivo and identify molecularly-guided treatment strategies, including HDAC and BET inhibitors for CALR mutant myelofibrosis patients.

    • Mattheus H. E. Wildschut
    • Julien Mena
    • Berend Snijder
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19
  • EGFRvIII-targeted CAR T cells have been proposed as a therapeutic option for patients with glioblastoma (GBM), however, clinical responses remain suboptimal. Here the authors engineer anti-EGFRvIII CAR T cells to secrete an optimized SIRPγ-derived CD47 blocker, showing that combining CAR T cell effector functions with enhanced macrophage-mediated tumor cell phagocytosis improves anti-tumor efficacy in preclinical models.

    • Tomás A. Martins
    • Deniz Kaymak
    • Gregor Hutter
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25
  • Single-cell measurements and lineage-tracing experiments are revealing that cell-to-cell variability is often the result of deterministic processes, despite the existence of intrinsic noise in molecular networks. As this determinism usually represents uncharacterized molecular regulatory mechanisms, cell-to-cell variability should be studied as a discipline of molecular cell biology.

    • Berend Snijder
    • Lucas Pelkmans
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 119-125
  • A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the physical interactions among peripheral mononuclear leukocytes revealed known immunomodulators and also approved drugs as regulators of unexpected targets, including MST1R.

    • Gregory I Vladimer
    • Berend Snijder
    • Giulio Superti-Furga
    Research
    Nature Chemical Biology
    Volume: 13, P: 681-690
  • This paper introduces and benchmarks a statistic, the hierarchical interaction score, a statistic for measuring functional interactions between genes from large-scale data, and provides accessible methods for calculating this score.

    • Berend Snijder
    • Prisca Liberali
    • Lucas Pelkmans
    Research
    Nature Methods
    Volume: 10, P: 1089-1092
  • The filamentous fungus expression system Thermothelomyces heterothallica (C1) is a protein expression system that may be useful for large scale antibody production. Here the authors characterise the production of a human monoclonal antibody that neutralises SARS-CoV-2 and compare functional properties in vitro and in animal models to antibodies produced using other methods.

    • Franziska K. Kaiser
    • Mariana Gonzalez Hernandez
    • Albert D.M.E. Osterhaus
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • Large-scale genetic perturbation screens have been central to many biological discoveries. This Review outlines the recent advances in the quantification of various perturbations across large numbers of single cells simultaneously and describes the use of genetic perturbation screens to infer functional interactions between genes and phenotypes.

    • Prisca Liberali
    • Berend Snijder
    • Lucas Pelkmans
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 18-32
  • Binding of a sialoglycan-based primary receptor by the spike protein of the common cold human coronavirus HKU1 triggers conformational changes to a state that would allow binding to a second receptor required for cell entry.

    • Matti F. Pronker
    • Robert Creutznacher
    • Daniel L. Hurdiss
    ResearchOpen Access
    Nature
    Volume: 624, P: 201-206
  • A neural epigenetic signature detectable via plasma analyses is prognostic in patients with glioblastoma, resembling an oligodendrocyte-progenitor- and neuronal-progenitor-cell-like state and showing increased neuro-to-glioma synapse formation.

    • Richard Drexler
    • Robin Khatri
    • Franz L. Ricklefs
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 1622-1635
  • Systematic measurements of the interactions between proteins found on the surfaces of human leukocytes provides a global view of the way that immune cells are dynamically connected by receptors.

    • Jarrod Shilts
    • Yannik Severin
    • Gavin J. Wright
    ResearchOpen Access
    Nature
    Volume: 608, P: 397-404
  • Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodies against this endemic coronavirus.

    • Chunyan Wang
    • Emma L. Hesketh
    • Berend-Jan Bosch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events.

    • Maik Müller
    • Fabienne Gräbnitz
    • Bernd Wollscheid
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17
  • Epigenome profiling in combination with imaging-based chemosensitivity and integrative bioinformatic analysis establishes a method for detecting therapy-induced vulnerabilities, as shown here for ibrutinib-treated chronic lymphocytic leukemia.

    • Christian Schmidl
    • Gregory I. Vladimer
    • Christoph Bock
    Research
    Nature Chemical Biology
    Volume: 15, P: 232-240
  • Immunology is on the cusp of a 'big data'–driven breakthrough, but strategies for standardizing and sharing high-dimensional data from independent laboratories are needed to ensure that data support the formation of new and robust hypotheses.

    • Berend Snijder
    • Richard Kumaran Kandasamy
    • Giulio Superti-Furga
    Comments & Opinion
    Nature Biotechnology
    Volume: 32, P: 755-759
  • Long-read single-cell RNA sequencing is capable of detecting isoform-level gene expression and genomic alterations such as mutations and gene fusions, thereby providing cell-specific genotype-phenotype information. Here, the authors use long-read scRNA-seq on metastatic ovarian cancer samples and detect cell-type specific isoforms and gene fusions that may otherwise be misclassified in short-read data.

    • Arthur Dondi
    • Ulrike Lischetti
    • Niko Beerenwinkel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19
  • The mTORC1 protein kinase complex integrates nutrient and growth stimuli to modulate signalling pathways that regulate cellular metabolism and physiology, but the molecular nature of the amino acid sensing mechanism at the lysosome is unknown; here, an orphan member of the human solute carrier group of proteins, SLC38A9, is shown to be an integral component of the lysosomal machinery that can directly sense amino acids and activate mTORC1.

    • Manuele Rebsamen
    • Lorena Pochini
    • Giulio Superti-Furga
    Research
    Nature
    Volume: 519, P: 477-481
  • The authors present a robust diagnostic algorithm based on digital pathology and image analysis that quantifies intratumoral and stromal CD8+ T-cell densities in the tumor center and invasive margin compartment in metastatic melanoma. Spatial CD8+ T-cell densities are translated into the clinically relevant immune diagnostic categories “inflamed”, “excluded”, and “desert”. Their approach also allows efficient immune phenotyping of metastatic lesions, on biopsy material or even in the absence of material from the invasive margin.

    • Bettina Sobottka
    • Marta Nowak
    • Viktor Hendrik Koelzer
    ResearchOpen Access
    Laboratory Investigation
    Volume: 101, P: 1561-1570