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Experiments realizing the indirect-drive fast ignition scheme for inertial confinement fusion are reported. Enabled by a tightly compressed target, an increase of neutron yield is observed.

African swine fever has spread to all Chinese provinces, limiting pork production and trade. Outbreaks occurring between 2018 and 2019 led to economic losses in pork and related industries—but projected future outbreaks could cause greater economic impacts.

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

The ASAP4 family of genetically encoded voltage indicators allows recording of action potentials and subthreshold activity with either one- or two-photon microscopy over extended periods of time.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Sarcomatoid and rhabdoid tumours are highly aggressive forms of renal cell carcinoma that are also responsive to immunotherapy. In this study, the authors perform a comprehensive molecular characterization of these tumours discovering an enrichment of specific alterations and an inflamed phenotype.

A high-quality Taxus genome provides insight into the genome evolution of the Taxus genus and the biosynthesis of paclitaxel.

Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, with high stability, tumor-specific targeting and long circulation time.

TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell death in melanoma cells that are resistant to spontaneous and drug-induced apoptosis.

Water adsorbed on the electrode surface of electrochemical energy storage devices narrows the electrochemical windows. Combining atomistic simulations and cyclic voltammetry experiments the authors demonstrate an approach to expand the voltage window of humid ionic liquids based on the addition of lithium salt.

An organic electrochemical transistor with a vertical traverse architecture and a crystalline–amorphous channel that can be selectively doped by ions can operate as a volatile receptor and a non-volatile synapse.

A whole monkey brain is imaged at high resolution in 100 hours.

The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.

This study examines the tempo and drivers of penguin diversification by combining genomes from all extant and recently extinct penguin lineages, stratigraphic data from fossil penguins and morphological and biogeographic data from all extant and extinct species. Together, these datasets provide new insights into the genetic basis and evolution of adaptations in penguins.

Jing Wang, Fengchun Zhang and colleagues report the results of a genome-wide association study of primary Sjögren's syndrome, a common autoimmune disease. They confirm associations in the STAT4, TNFAIP3 and HLA regions and identify a new susceptibility locus in the GTF2I region at 7q11.23.

The biological and clinical implications of high genome instability in esophageal squamous cell carcinoma (ESCC) remain to be explored. Here, the authors analyse 528 whole genomes and investigate the landscape and molecular mechanisms underlying structural variations in ESCC patients.

Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistant breast cancer PDXs to NAC.

Depletion of calcium from intracellular stores induces interaction between the endoplasmic reticulum STIM1 protein and the plasma membrane ORAI1 channel that facilitates cellular calcium entry. Here Ma et al. characterize a STIM1 gain-of-function mutant and propose a conformational switch that controls ORAI1 gating.

The precise mechanisms by which the adaptor CARD9 facilitates resistance to bacterial infection remain unclear. Lin and colleagues document a role for CARD9 in the production of microbicidal reactive oxygen species.

Implantation-caused foreign-body response is a commonly encountered issue and can result in failure of implants. Here, the authors demonstrate that a highly water soluble, biocompatible, and easily accessible poly-DL-serine hydrogel can mitigate foreign-body response.

A stable, low-temperature water–gas shift catalyst is achieved by crowding platinum atoms and clusters on α-molybdenum carbide; the crowding protects the support from oxidation that would cause catalyst deactivation.

The authors found that the olfactory perception of food abundance can regulate the impact of dietary restriction on longevity in Caenorhabditis elegans. They show that food odors act on olfactory circuitry that signals the gut via octopamine to suppress dietary restriction-induced longevity.

TCP1 promotes tumour progression by disrupting the degradation of the oncogene c-Myc in the context of hepatocellular carcinoma and pancreatic ductal adenocarcinoma.

A Farey tree locking method is experimentally implemented to lock the repetition frequency of terahertz quantum cascade laser frequency combs and stabilize the dual-comb operation.

An asteroseismic and spectroscopic analysis of lithium-rich stars improves their classification based on the distributions of lithium, nitrogen and mass, and reveals that most of these evolved stars are red clump rather than red giant branch stars.

Reduction on cobalt reliance is an urgent requirement in the development of sustainable cathode materials for Li-ion batteries. Here the authors analyse the roles of cobalt and its interplay with other ions in high-nickel layered oxides, and deduce a material formula for promising cobalt-free cathodes.

Notch signaling is shown to regulate the browning of adipocytes and whole-body energy expenditure, with inhibition leading to protection from diet-induced obesity in mice.

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Plant pathogens produce effector proteins that enhance virulence in susceptible plants, but trigger an immune response in resistant plants. This hypersensitive response is elicited through the interaction between the bacterial effector and the appropriate host resistance protein. This study describes the first crystal structure of a pathogen effector (AvrPto) bound to its cognate host protein (Pto).

The electrochemical performance of supercapacitors can be enhanced with porous electrodes. Molecular dynamics simulations can now help to clarify the double-layer structure and capacitive performance of supercapacitors composed of MOF electrodes and ionic liquid electrolytes.

In epithelial cells Zeb1 is involved in the epithelial to mesenchymal transition. In this study, the authors show in a mouse model of breast cancer, that Zeb1 expression in stromal cells is required for tumour formation and metastasis.

Semiconducting covalent organic frameworks (COF) with conjugated structures are desired for optoelectric conversion but poor reversibility of bond forming reactions hampers the formation of crystalline structures. Here, the authors synthesise COFs with disubstituted C = C linkages which enable water splitting under visible light irradiation.