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Extreme weather events will require resilient and adaptive critical infrastructure. This study models adaptive transitions in collective travel behaviour during flood events across different cities to quantify recovery and adaptive learning from failures and reveal adaptation drivers.

Endothelial injury drives vascular diseases like atherosclerosis, but key regulators are unclear. Here, the authors show that endothelial major vault protein (MVP) acts as an intracellular regulator promoting Parkin-mediated mitophagy, thereby antagonizing vascular remodeling and suggesting its role as a potential therapeutic target.

Tear secretion from lacrimal gland is essential for ocular health, but the regulatory role of sympathetic nervous system is unclear. The authors show that sympathetic activation suppresses lacrimal tear secretion and aggravates dry eye disease via NA–Adra1a–Ucp2 signaling.

Non-shivering thermogenesis in brown adipose tissue (BAT) is tightly controlled by innervation. Here, the authors show that BAT-derived OLFM4 regulates Schwann cell differentiation through activation of the BMP7-MEK/ERK pathway, thereby modulating sensory and sympathetic innervation

Here the authors establish a high throughput Pore-C (HiPore-C) method increasing the sequencing output of multi-way chromatin contacts and reveal single-allele topology diversity and cell type-specificity of 3D genome folding.

The suboptimal interfacial contacts between nickel oxide and self-assembled monolayers in wide bandgap subcells limit the photovoltaic efficiency and stability. Here, authors employ boric acid as an anchoring group for chemisorption, achieving efficiency of 28.5% for two-terminal tandem solar cells.

Cerebrovascular abnormalities are key indicators of stroke and neurodegenerative diseases. Here, the authors show evolutionary trends of cortical and vascular volumes across spatial hierarchies with a deep learning-based pipeline and varying volume reductions in different brain pathologies.

Hydrogels are of increasing interest in the materials community, but precise control of mechanochemistry is still challenging. Here, the authors report the use of a tensegrity architecture to prepare hydrogels with favourable properties.

Genomic studies often lack representation from diverse populations, limiting equitable insights. Here, the authors show that the BIG Initiative captures extensive genetic diversity and reveals ancestry-linked health disparities in a community-based Mid-South cohort.

Here, the authors develop a systematic approach (Dip3D) for unraveling diploid high-order genome interactions for low-heterozygosity genomes using Pore-C. Using Dip3D they obtain an almost complete diploid three-dimensional genome interaction map for a human genome.

To increase the efficiency, brightness and stability of next-generation light-emitting diodes (LEDs), the microstructure of CsPbI_3-xBr_x metal-halide perovskite, a good pure-red emitter, was altered to fix hole leakage, which was identified as decreasing efficiencies in overworked LEDs.

Microneedles offer a minimally invasive transdermal drug delivery method with advantages like painless administration. Here, the authors developed a pneumatic microneedle patch powered by live Enterobacter aerogenes to enhance and control drug delivery, significantly improving treatment outcomes in a psoriasis model.

Inflammatory immune cells are found in the synovial fluid of patients with rheumatoid arthritis (RA). Here the authors use scRNA sequencing of synovial fluid cells from RA patients before and after treatment with adalimumab/tofacitinib and find changes in inflammatory SPP1+ macrophages and explore the function of these cells in mouse models.

Organic luminescent materials attract attention due to their wide application range, but many organic luminogens suffer from severe quenching effect in the aggregate state. Here, the authors demonstrate a macrocyclization induced emission enhancement by linking luminophores through methylene bridges to give a macrocycle.

Achieving high-performance conjugated polymers with intrinsic flexibility and printable capacity is a great challenge. Here, the authors report asymmetric substituted polymers with strong inter aggregate capillary interaction for deep-blue flexible printed polymer light-emitting diodes.

Endothelial dysfunction has been shown to occur in HFpEF and we know that statins can target endothelial dysfunction by inhibiting miR-133a. Here the authors show that statins improve diastolic dysfunction in HFpEF by increasing the levels of a circRNA which, in turns, binds to miR-133a modulating its downstream targets.

Zhong et al. find that SERRATE (SE) regulates the m⁶A methyltransferase complex (MTC) to control m⁶A deposition, and show cross-regulation between the MTC and the SE-mediated microprocessor governs miRNA production in Arabidopsis.

Here the authors study diet-induced weight gain/loss to identify chromatin architectures in adipose tissue (AT) associated obesity in a pig model. They found parallels and species-specific regulatory elements in humans and pigs that underpin AT specialization.

Because open-circuit voltage deficit is greater in wide-bandgap perovskite solar cells, the authors introduce diammonium molecules to modify perovskite surface states and achieve a more uniform spatial distribution of surface potential, enabling record voltage all-perovskite tandem solar cells.

M-OFDFT is a deep learning implementation of orbital-free density functional theory (OFDFT) that achieves DFT-level accuracy on molecular systems with lower cost complexity, and can extrapolate to much larger molecules than those seen during training.

It is not well understood why some metallic glasses display clear experimental evidence of β-relaxations, whereas others do not. Here, by studying enthalpies of mixing in glass-forming compositions, Yu et al. suggest that string-like atomic configurations may account for their observation.

Macrophage TP53-induced glycolysis and apoptosis regulator (TIGAR) is implicated in a range of immunopathology. Here the authors show TIGAR drives inflammation and sepsis via activation of TAK1 and that disruption of TIGAR-TAK1 interaction in a murine model of sepsis reduces immunopathology.

The ultrathin oxide nanosheets obtained through previous approaches usually exhibit amorphism or polycrystallinity, which limit their properties towards electronic devices. Here, the authors synthesize ultrathin antimony oxide single crystals with high dielectric constant (~100) and large breakdown voltage (~5.7 GV m⁻¹).

Lipid droplets (LDs) and their membrane proteins play essential roles in many biological processes, but the monolayer lipid membrane of LDs has not been extensively studied due to the lack of suitable molecular probes. Here, the authors report an LD membrane labelling pro-probe called LDM, which, upon activation by the HClO/ClO− microenvironment that surrounds LDs, undergoes a color change and releases LDM-OH probe that binds to LD membrane proteins.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

This study explores the magnitude, spatiotemporal variation and drivers of nitrous oxide emissions from Chinese livestock production over the past four decades. Scenario analysis is used to estimate emissions mitigation potential of different measures, their associated marginal abatement costs and the social benefits.

Confocal light-field microscopy allows volumetric voltage imaging in the mouse brain at speeds sufficiently high to extract the spiking activity of hundreds of neurons.

Hydrogel-based flexible sensors have potential in a number of fields, but mechanical properties can be compromised as a result of water evaporation. Here, the authors report a method for limiting of water loss by addition of a lipid-based coating to the surface of the hydrogel.

MoDL, a deep learning algorithm, is developed to link mitochondrial morphology and function. Trained on extensive mitochondrial image and biochemical data, MoDL delivers high segmentation accuracy and accurate function prediction.

A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

The authors show that neuroprotective and neurotoxic astrocytes represent transitional cellular substates present during neuroinflammation and that targeting mTOR in astrocytes reduces neurotoxicity, suggesting a potential therapeutic strategy for neurodegenerative diseases.

Stroke is a multifactorial disease influenced by genetic and environmental factors. Here, the authors apply exome-wide association analysis to find rare coding variants associated with stroke in a Pakistani cohort, finding a significant association of a variant in NOTCH3 that is highly enriched in South Asians.

A scheme to control the confinement within 2D/3D perovskite heterostructures results in stable, efficient inverted perovskite solar cells.

Large-scale, comprehensive proteomic profiling of Alzheimer’s disease brain and cerebrospinal fluid reveals disease-associated protein coexpression modules and highlights the importance of glia and energy metabolism in disease pathogenesis.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

SARS-CoV-2 Omicron variant evolves into multiple sub-variants. Here, authors evaluate the binding capacity of these sub-variants to human and animal ACE2s and reveal molecular bases for their receptor binding and broader interspecies recognition.

To address substrate inhibition in wastewater treatment, the authors propose a non-lethal high substrate environment to enhance microbial community resistance. Testing this on anammox systems, they find increased nitrite tolerance and stability, with a shift to the dominant genus Candidatus Jettenia.

Skull base chordomas are treated with surgery and chemotherapy but often recur due to incomplete resection, understanding the molecular underpinnings of the tumours may provide additional therapeutic strategies. Here, the authors carry out whole genome sequencing of 80 skull base chordoma tumours and identify the SWI/SNF component—PBRM1—as a frequently mutated gene.

Plasmonic-enhanced nanosensors are limited in practical applications, as it remains challenging to detect molecules at low concentrations. Here, the authors introduce a buoyant particulate strategy in order to enrich analytes in the plasmonic hot spots.

It is desirable yet challenging to develop sustainable structural materials to replace petroleum-based plastics. Here, the authors report a facile assembly method for manufacturing high-performance structural materials with a unique combination of high strength, toughness and stiffness.

This study reports a fully integrated 128 × 8 optoelectronic memristor array with Si complementary metal–oxide–semiconductor circuits, featuring configurable multi-mode functionality. It demonstrates diversified in-sensor computing tasks and consumes 20 times less energy than GPUs.