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DARPin-induced reactivation of p53 in HPV-positive cells

The binding of a DARPin to p53 displaces the human papillomavirus (HPV) E6 protein and stabilizes p53 in HPV-infected cells. This interaction reactivates a p53-dependent transcriptional program, suggesting a potential new therapeutic strategy for treating HPV-induced cancers.

Philipp Münick
Alexander Strubel
Volker Dötsch
Research09 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 790-801
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization

The third variable (V3) loop on the HIV-1 Env glycoprotein is required for viral entry. Here, the authors applied DARPin technology to produce broadly neutralizing inhibitors targeting a region of V3 that becomes accessible after binding to the CD4 receptor.

Matthias Glögl
Nikolas Friedrich
Alexandra Trkola
ResearchOpen Access21 Aug 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1323-1336
Nuclear myosin VI maintains replication fork stability

Whether actin and associated molecules have roles in the nucleus is an active area of study. Here Shi et al. report a nuclear function of the actin-based motor myosin VI in protecting stalled replication forks from nuclease-mediated degradation.

Jie Shi
Kristine Hauschulte
Hans-Peter Wollscheid
ResearchOpen Access24 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Structural basis of adenylyl cyclase 9 activation

Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes, AC9.

Chao Qi
Pia Lavriha
Volodymyr M. Korkhov
ResearchOpen Access24 Feb 2022
Nature Communications

Volume: 13, P: 1-11
Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors

The clinical use of adeno-associated virus vectors (AAVs) has been limited by the lack of transduction specificity. Here the authors show that receptor-targeted, affinity-tagged, and purified AVVs reach tumours in mouse models with high selectivity and efficiency, outperforming therapeutic antibodies.

Robert C. Münch
Anke Muth
Christian J. Buchholz
Research10 Feb 2015
Nature Communications

Volume: 6, P: 1-9
Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

ADP-ribose binding macro domains facilitate the enrichment and detection of cellular ADP-ribosylation. Here, the authors generate an engineered macro ___domain with increased ADP-ribose affinity, improving the identification of ADP-ribosylated proteins by proteomics, western blot and immunofluorescence.

Kathrin Nowak
Florian Rosenthal
Michael O. Hottiger
ResearchOpen Access15 Oct 2020
Nature Communications

Volume: 11, P: 1-14
DARPins as a novel tool to detect and degrade p73

Philipp Münick
Jasmin Zielinski
Volker Dötsch
ResearchOpen Access18 Dec 2024
Cell Death & Disease

Volume: 15, P: 1-14
Structure of a kinesin–tubulin complex and implications for kinesin motility

Combined with kinetic analyses, the high resolution structure of kinesin-1 bound to a tubulin dimer offers a much-anticipated view of the motor-microtubule interface that illuminates the key step of neck-linker docking and of the structural basis for microtubule-accelerated ATP hydrolysis and motility.

Benoît Gigant
Weiyi Wang
Marcel Knossow
Research21 Jul 2013
Nature Structural & Molecular Biology

Volume: 20, P: 1001-1007
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells.

Markus Schmid
Patrick Ernst
Andreas Plückthun
ResearchOpen Access31 Jan 2018
Nature Communications

Volume: 9, P: 1-16
DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma

Alexander Strubel
Philipp Münick
Volker Dötsch
ResearchOpen Access12 Oct 2023
Cell Death & Disease

Volume: 14, P: 1-12
Designed Ankyrin Repeat Proteins as a tool box for analyzing p63

Alexander Strubel
Philipp Münick
Volker Dötsch
ResearchOpen Access18 Jun 2022
Cell Death & Differentiation

Volume: 29, P: 2445-2458
Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer

Jean-Philippe Theurillat
Birgit Dreier
Holger Moch
Research21 May 2010
Modern Pathology

Volume: 23, P: 1289-1297
Assessing immunogenicity barriers of the HIV-1 envelope trimer

Liridona Maliqi
Nikolas Friedrich
Alexandra Trkola
ResearchOpen Access30 Sept 2023
npj Vaccines

Volume: 8, P: 1-14
Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin

Shoeb Ahmad
Ludovic Pecqueur
Benoît Gigant
ResearchOpen Access06 Jul 2016
Scientific Reports

Volume: 6, P: 1-14

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