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Author Correction: Mild hypothermia provides Treg stability

Natalia Marek- Trzonkowska
Karolina Piekarska
Piotr Trzonkowski
Amendments and CorrectionsOpen Access15 Dec 2017
Scientific Reports

Volume: 7, P: 1
Autoimmunity and transplantation: a meeting at the crossroads in Berlin

Every 2 years, scientists interested in immunomodulation meet to discuss new opportunities arising from interactions between basic science and clinical 'translation'. This report discusses the 8th International Conference on New Trends in Immunosuppression and Immunotherapy, 2008, in Berlin.

Birgit Sawitzki
Petra Reinke
Laurence A Turka
News & Views01 May 2008
Nature Immunology

Volume: 9, P: 447-449
TGFβ links EBV to multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

Carl Christoph Goetzke
Mona Massoud
Mir-Farzin Mashreghi
ResearchOpen Access12 Mar 2025
Nature

Volume: 640, P: 762-771
The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination

Maatz, Lindberg et al. identify molecular alterations and immune response changes in endomyocardial biopsies from patients with myocarditis after COVID-19 infection, after anti-COVID-19 vaccination or from non-COVID-related causes.

Henrike Maatz
Eric L. Lindberg
Carsten Tschöpe
ResearchOpen Access24 Feb 2025
Nature Cardiovascular Research

Volume: 4, P: 330-345
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4⁺ memory T cells

Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.

Kim-Long Truong
Stephan Schlickeiser
Birgit Sawitzki
ResearchOpen Access22 May 2019
Nature Communications

Volume: 10, P: 1-15
Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases

Patients with autoimmune diseases require immunosuppressive treatments that affect their responses to infection and vaccination. Here, using mass cytometry, the authors to identify a role for myeloid cells in cellular and humoral responses following vaccination against SARS-CoV-2 in patients with neuroimmunological diseases.

Meng Wang
Adeline Dehlinger
Chotima Böttcher
ResearchOpen Access25 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

The immune response is key in determining disease severity of COVID19. Here Nouailles et al., apply bulk proteomics and scRNA-Seq of lung and blood samples of SARS-CoV-2 infected Syrian hamsters and provide a temporal atlas of the systemic and pulmonary cellular responses.

Geraldine Nouailles
Emanuel Wyler
Martin Witzenrath
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-18
CD4⁺ T cell calibration of antigen-presenting cells optimizes antiviral CD8⁺ T cell immunity

Bedoui and colleagues describe a sequential process of integration of innate and CD40-delivered signals in APCs, which optimizes their capacity to drive antiviral CD8⁺ T cell responses.

Elise Gressier
Jonas Schulte-Schrepping
Sammy Bedoui
Research15 May 2023
Nature Immunology

Volume: 24, P: 979-990
Single-cell analysis based dissection of clonality in myelofibrosis

Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.

Elena Mylonas
Kenichi Yoshida
Frederik Damm
ResearchOpen Access07 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary. Here authors establish, with an array of state-of-the art methods, the major immunological parameters that distinguish vaccine recipients developing robust antibody response and non-responders

Peggy Riese
Stephanie Trittel
Carlos A. Guzmán
ResearchOpen Access12 Nov 2022
Nature Communications

Volume: 13, P: 1-21
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

The improper timing of transforming growth factor-β production is a hallmark of severe COVID-19 that may impede natural killer cell function and early control of infection.

Mario Witkowski
Caroline Tizian
Andreas Diefenbach
Research25 Oct 2021
Nature

Volume: 600, P: 295-301
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.

Baptiste Lamarthée
Armance Marchal
Julien Zuber
ResearchOpen Access08 Nov 2021
Nature Communications

Volume: 12, P: 1-19
TIGIT⁺ iTregs elicited by human regulatory macrophages control T cell immunity

Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT⁺ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients.

Paloma Riquelme
Jan Haarer
James A. Hutchinson
ResearchOpen Access20 Jul 2018
Nature Communications

Volume: 9, P: 1-18
Swarm Learning for decentralized and confidential clinical machine learning

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Stefanie Warnat-Herresthal
Hartmut Schultze
Joachim L. Schultze
ResearchOpen Access26 May 2021
Nature

Volume: 594, P: 265-270
IRF1 and BATF—transcription factors that set the epigenetic landscape for Tr1 cell differentiation?

Katarina Stanko
Birgit Sawitzki
Research Highlights10 Jul 2017
Cellular & Molecular Immunology

Volume: 14, P: 727-729
Mild hypothermia provides Treg stability

Natalia Marek-Trzonkowska
Karolina Piekarska
Piotr Trzonkowski
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-15
A two-way street – cellular metabolism and myofibroblast contraction

Anne Noom
Birgit Sawitzki
Georg N. Duda
ReviewsOpen Access03 Apr 2024
npj Regenerative Medicine

Volume: 9, P: 1-12

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