Jacobsen and colleagues elucidate the nonhierarchical relationship between two types of stem cells: Vwf− hematopoietic stem cells that stably replenish all blood cell lineages without a platelet bias, and Vwf+ stem cells that replenish almost exclusively platelets, and demonstrate that the two types utilize cellularly and molecularly distinct progenitor trajectories for replenishment of platelets.
- Joana Carrelha
- Stefania Mazzi
- Sten Eirik W. Jacobsen
