Here the authors report that the yeast ubiquitin E3 ligase Bre1 and its human homolog RNF20 function as recombination mediator proteins by promoting Rad51-ssDNA assembly, Rad51 replacement of ssDNA-bound RPA while antagonizing the activities of Srs2 or FBH1 anti-recombinase.
- Guangxue Liu
- Jimin Li
- Xuefeng Chen
