Nature Search

PcdA promotes orthogonal division plane selection in Staphylococcus aureus

PcdA interacts with DivIVA and FtsZ, promoting Z-ring formation and division plane selection in Staphylococcus aureus, which increases virulence in mice and reduces sensitivity to cell-wall-targeting antibiotics.

Félix Ramos-León
Brandon R. Anjuwon-Foster
Kumaran S. Ramamurthi
Research28 Oct 2024
Nature Microbiology

Volume: 9, P: 2997-3012
Histidine 73 methylation coordinates β-actin plasticity in response to key environmental factors

Histidine 73 methylation in β-actin modulates actin plasticity, affecting monomer dynamics and filament stability. Using molecular dynamics simulations, the study reveals that methylation influences nucleotide binding cleft opening and phosphate release.

Adrien Schahl
Louis Lagardère
Jean-Philip Piquemal
ResearchOpen Access07 Mar 2025
Nature Communications

Volume: 16, P: 1-13
Impacts of reproductive systems on grapevine genome and breeding

Effects of reproductive systems on crop genomic variation and breeding remain unclear. Here, the authors report that reproductive types impact genomic landscapes and grapevine breeding based on comparative genomic and population genetic analyses of wild grapevine and a complex pedigree of Pinot Noir.

Hua Xiao
Yue Wang
Yongfeng Zhou
ResearchOpen Access03 Mar 2025
Nature Communications

Volume: 16, P: 1-15
Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels

Stephen J. Delaney
Devra P. Rich
Brandon J. Wainwright
Research01 Aug 1993
Nature Genetics

Volume: 4, P: 426-430
Tilt and northward offset of Cordilleran batholiths resolved using igneous barometry

Jay J. Ague
Mark T. Brandon
Research12 Nov 1992
Nature

Volume: 360, P: 146-149
Induction of Apoptosis in neoplastic cells by depletion of vitamin B₁₂

P Roy Walker
Brandon Smith
A Charles Morgan
Research01 Apr 1997
Cell Death & Differentiation

Volume: 4, P: 233-241
Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus

Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13⁺ T_PH/T_FH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

Calvin Law
Vanessa Sue Wacleche
Deepak A. Rao
Research10 Jul 2024
Nature

Volume: 631, P: 857-866
Stabilization of three-dimensional charge order through interplanar orbital hybridization in Pr_xY_1−xBa₂Cu₃O_6+δ

External perturbations can induce 3D charge order in cuprates, but the 3D correlation length is limited and the mechanism is not well understood. Ruiz et al. show that Pr substitution in YBa₂Cu₃O₇enhances interplanar orbital coupling and stabilizes coherent 3D charge order that coexists with superconductivity.

Alejandro Ruiz
Brandon Gunn
Alex Frano
ResearchOpen Access19 Oct 2022
Nature Communications

Volume: 13, P: 1-7
HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.

Jie Zheng
Chen Wang
Patrick R. Griffin
ResearchOpen Access18 Dec 2018
Nature Communications

Volume: 9, P: 1-12
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

Daniel Taliun
Daniel N. Harris
Gonçalo R. Abecasis
ResearchOpen Access10 Feb 2021
Nature

Volume: 590, P: 290-299
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Clinical multi-omics data are integrated and analyzed using a generative deep-learning model.

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
ResearchOpen Access02 Jan 2023
Nature Biotechnology

Volume: 41, P: 399-408
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Many genetic variants have been associated with human traits, but the mechanism is often unknown. Here, the authors integrate local and distal genetic associations with multi-omics datasets to provide a roadmap to understand the underlying mechanisms of GWAS variants on complex traits.

Andrew A. Brown
Juan J. Fernandez-Tajes
Ana Viñuela
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Author Correction: Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

Moritz Mall
Michael S. Kareta
Marius Wernig
Amendments and Corrections04 Jun 2024
Nature

Volume: 630, P: E11
A modular architecture for organizing, processing and sharing neurophysiology data

A modular architecture for managing and sharing electrophysiology, behavior, colony management and other data has been built to support individual laboratories or large consortia.

Luigi Acerbi
Valeria Aguillon-Rodriguez
Miles J. Wells
Research02 Mar 2023
Nature Methods

Volume: 20, P: 403-407
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

All forms of diabetes eventually lead to a reduction in insulin-secreting pancreatic β-cells. Here, the authors report aminopyrazine derivatives, which induce proliferation of rodent as well as human β-cells and improve glucose metabolism in a mouse model of type 1 diabetes.

Weijun Shen
Brandon Taylor
Bryan Laffitte
ResearchOpen Access26 Oct 2015
Nature Communications

Volume: 6, P: 1-11
Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Fifty-five percent of individuals vaccinated with an attenuated Plasmodium falciparum sporozoite vaccine remained without parasitemia after controlled human malaria infection one year later; immune correlate analysis in humans and non-human primates suggest a role for liver-resident T cells.

Andrew S Ishizuka
Kirsten E Lyke
Robert A Seder
Research09 May 2016
Nature Medicine

Volume: 22, P: 614-623
Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging

Age-related cognitive decline is paralleled by two other prominent brain changes: structural atrophy prominent in medial prefrontal cortex (mPFC) and disrupted non-rapid eye movement (NREM) slow-wave sleep (SWS). This study establishes an interaction between these factors, demonstrating that the extent of mPFC atrophy predicts the degree of impaired NREM SWS quality, thereby compromising hippocampal-dependent memory consolidation in the aging human brain.

Bryce A Mander
Vikram Rao
Matthew P Walker
Research27 Jan 2013
Nature Neuroscience

Volume: 16, P: 357-364
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

The mechanisms through which β-amyloid impairs human memory remain unclear. This study shows that regional-specific β-amyloid load in cognitively normal older adults impairs NREM slow wave oscillations, thereby compromising overnight hippocampus-dependent memory consolidation. NREM sleep disruption therefore represents a novel mechanistic pathway through which β-amyloid contributes to hippocampus-dependent memory dysfunction in later life.

Bryce A Mander
Shawn M Marks
Matthew P Walker
Research01 Jun 2015
Nature Neuroscience

Volume: 18, P: 1051-1057
A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

Human immunodeficiency virus (HIV) fails to induce interferon in the cells that it infects, but the underlying mechanisms are not known. These authors show that the virus can in fact activate the interferon pathway in dendritic cells when the usual block to infection is bypassed. Dendritic cell activation depends on the HIV-1 capsid/cyclophilin A interaction, which is known to have a role in HIV-1 infectivity.

Nicolas Manel
Brandon Hogstad
Dan R. Littman
Research09 Sept 2010
Nature

Volume: 467, P: 214-217
A reference map of potential determinants for the human serum metabolome

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Noam Bar
Tal Korem
Eran Segal
Research11 Nov 2020
Nature

Volume: 588, P: 135-140
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

The Microarray Quality Control consortium pitted 36 teams against each other to evaluate methods for creating genomic classifiers, computational tools for interpreting gene expression profiles. The performance of the classifiers on blinded validation data—and metadata on the analytic methods—reveal the challenges facing the field.

Leming Shi
Gregory Campbell
Russell D Wolfinger
Research30 Jul 2010
Nature Biotechnology

Volume: 28, P: 827-838
Functional lower extremity strength influences stepping strategy in community-dwelling older adults during single and dual-task walking

Brandon M. Peoples
Kenneth D. Harrison
Jaimie A. Roper
ResearchOpen Access11 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
The obesogenic effect of high fructose exposure during early development

Fructose is increasingly being used in food supply. In this Perspectives, the authors discuss the links between fructose intake and obesity; in particular, the negative effects of fructose exposure during early development are highlighted.

Michael I. Goran
Kelly Dumke
Bruce Blumberg
Reviews04 Jun 2013
Nature Reviews Endocrinology

Volume: 9, P: 494-500
Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

The neuron-specific transcription factor Myt1l represses many somatic lineage programs, but not the neuronal lineage program, to both induce and maintain neuronal identity.

Moritz Mall
Michael S. Kareta
Marius Wernig
Research05 Apr 2017
Nature

Volume: 544, P: 245-249
The distribution of fitness effects of new mutations

Mutations can be deleterious, neutral or, in rare cases, advantageous. The relative frequencies of these types across a genome constitutes the distribution of fitness effects. The properties of this distribution have important consequences in both medical and evolutionary genetics.

Adam Eyre-Walker
Peter D. Keightley
Reviews01 Aug 2007
Nature Reviews Genetics

Volume: 8, P: 610-618
The evolution of isochores

Adam Eyre-Walker
Laurence D. Hurst
Reviews01 Jul 2001
Nature Reviews Genetics

Volume: 2, P: 549-555
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
Amendments and CorrectionsOpen Access02 May 2023
Nature Biotechnology

Volume: 41, P: 1026
A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo

A computational design strategy is used to develop an affinity-enhanced ACE2 decoy, which is shown to be effective at neutralizing omicron subvariants in vitro and in vivo.

Brandon Havranek
Graeme Walker Lindsey
Shahidul M. Islam
ResearchOpen Access12 May 2023
Communications Biology

Volume: 6, P: 1-16
Estimating vaccine coverage in conflict settings using geospatial methods: a case study in Borno state, Nigeria

Alyssa N. Sbarra
Sam Rolfe
Jonathan F. Mosser
ResearchOpen Access08 Jul 2023
Scientific Reports

Volume: 13, P: 1-8
Multigenic resistance to Xylella fastidiosa in wild grapes (Vitis sps.) and its implications within a changing climate

Potential resistance genes for Xylella fastidiosa in wild grapes are identified and resistance is shown to be climate dependent.

Abraham Morales-Cruz
Jonas Aguirre-Liguori
Brandon S. Gaut
ResearchOpen Access30 May 2023
Communications Biology

Volume: 6, P: 1-15
The dynamics of γδ T cell responses in nonhuman primates during SARS-CoV-2 infection

The dynamics of γδ T cell frequencies and functions through the course of SARS-CoV-2 infection in rhesus macaques and African green monkeys reveals that Vδ1 γδ T cells are involved in the early immune response to SARS-CoV-2 infection.

Alyssa C. Fears
Edith M. Walker
Namita Rout
ResearchOpen Access16 Dec 2022
Communications Biology

Volume: 5, P: 1-14
Evolutionary analysis of a streamlined lineage of surface ocean Roseobacters

Haiwei Luo
Brandon K Swan
Mary Ann Moran
Research23 Jan 2014
The ISME Journal

Volume: 8, P: 1428-1439
Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse

Anaïs B. Thijssen
Karen Chartier
Jeanne E. Savage
ResearchOpen Access25 Jul 2023
Molecular Psychiatry

Volume: 28, P: 4225-4233
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Beer Flavor Provokes Striatal Dopamine Release in Male Drinkers: Mediation by Family History of Alcoholism

Brandon G Oberlin
Mario Dzemidzic
David A Kareken
Research15 Apr 2013
Neuropsychopharmacology

Volume: 38, P: 1617-1624

Search

PcdA promotes orthogonal division plane selection in Staphylococcus aureus

Histidine 73 methylation coordinates β-actin plasticity in response to key environmental factors

Impacts of reproductive systems on grapevine genome and breeding

Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels

Tilt and northward offset of Cordilleran batholiths resolved using igneous barometry

Induction of Apoptosis in neoplastic cells by depletion of vitamin B₁₂

Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus

Stabilization of three-dimensional charge order through interplanar orbital hybridization in Pr_xY_1−xBa₂Cu₃O_6+δ

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Author Correction: Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

A modular architecture for organizing, processing and sharing neurophysiology data

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

A reference map of potential determinants for the human serum metabolome

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Functional lower extremity strength influences stepping strategy in community-dwelling older adults during single and dual-task walking

The obesogenic effect of high fructose exposure during early development

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

The distribution of fitness effects of new mutations

The evolution of isochores

Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo

Estimating vaccine coverage in conflict settings using geospatial methods: a case study in Borno state, Nigeria

Multigenic resistance to Xylella fastidiosa in wild grapes (Vitis sps.) and its implications within a changing climate

The dynamics of γδ T cell responses in nonhuman primates during SARS-CoV-2 infection

Evolutionary analysis of a streamlined lineage of surface ocean Roseobacters

Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse

The United States COVID-19 Forecast Hub dataset

Beer Flavor Provokes Striatal Dopamine Release in Male Drinkers: Mediation by Family History of Alcoholism

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