Nature Search

Integrated multimodal cell atlas of Alzheimer’s disease

The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

Mariano I. Gabitto
Kyle J. Travaglini
Ed S. Lein
ResearchOpen Access14 Oct 2024
Nature Neuroscience

Volume: 27, P: 2366-2383
Integrating multimodal data to understand cortical circuit architecture and function

This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architecture, mechanisms and function of cortical circuits.

Anton Arkhipov
Nuno da Costa
Hongkui Zeng
Reviews24 Mar 2025
Nature Neuroscience

Volume: 28, P: 717-730
Comparative cellular analysis of motor cortex in human, marmoset and mouse

An examination of motor cortex in humans, marmosets and mice reveals a generally conserved cellular makeup that is likely to extend to many mammalian species, but also differences in gene expression, DNA methylation and chromatin state that lead to species-dependent specializations.

Trygve E. Bakken
Nikolas L. Jorstad
Ed S. Lein
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 111-119
Human neocortical expansion involves glutamatergic neuron diversification

Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that characterizes the greater complexity of the human neocortex.

Jim Berg
Staci A. Sorensen
Ed S. Lein
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 151-158
Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

Jim Berg
Staci A. Sorensen
Ed S. Lein
Amendments and CorrectionsOpen Access06 Jan 2022
Nature

Volume: 601, P: E12
Author Correction: Comparative cellular analysis of motor cortex in human, marmoset and mouse

Trygve E. Bakken
Nikolas L. Jorstad
Ed S. Lein
Amendments and CorrectionsOpen Access22 Mar 2022
Nature

Volume: 604, P: E8
Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons

Little is known about von Economo neurons, which have been described in a subset of mammals and appear to be selectively lost in several human neurological diseases. Here, authors reveal the gene expression profile of these cells and show that they are likely long-distance projection neurons.

Rebecca D. Hodge
Jeremy A. Miller
Ed S. Lein
ResearchOpen Access03 Mar 2020
Nature Communications

Volume: 11, P: 1-14
A multimodal cell census and atlas of the mammalian primary motor cortex

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Edward M. Callaway
Hong-Wei Dong
Susan Sunkin
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 86-102
Mycoplasma suis infection in pigs after splenectomy

Brian T. Dent
Karla A. Stevens
Jeffrey W. Clymer
Research20 Mar 2013
Lab Animal

Volume: 42, P: 125-128
A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits

Jonathan T. Ting
Brian Kalmbach
Ed Lein
ResearchOpen Access30 May 2018
Scientific Reports

Volume: 8, P: 1-13

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Integrated multimodal cell atlas of Alzheimer’s disease

Integrating multimodal data to understand cortical circuit architecture and function

Comparative cellular analysis of motor cortex in human, marmoset and mouse

Human neocortical expansion involves glutamatergic neuron diversification

Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

Author Correction: Comparative cellular analysis of motor cortex in human, marmoset and mouse

Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons

A multimodal cell census and atlas of the mammalian primary motor cortex

Mycoplasma suis infection in pigs after splenectomy

A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits

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