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Showing 1–2 of 2 results
Advanced filters: Author: Cécile Dulary Clear advanced filters

  • Here, the authors show that the canonical BRG/BRM-associated factor (SWI/SNF) chromatin remodeler generates subnucleosomes containing 50–80 bp of DNA associated with the four core histones. These hemisome-like particles interact with OCT4 to expand its binding ___domain at enhancers.

    • Marina C. Nocente
    • Anida Mesihovic Karamitsos
    • Matthieu Gérard
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1756-1768

  • Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

    • Rebecca Sims
    • Sven J van der Lee
    • Gerard D Schellenberg
    Research
    Nature Genetics
    Volume: 49, P: 1373-1384