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Showing 1–4 of 4 results
Advanced filters: Author: Carlos Outeiral Clear advanced filters
  • Machine learning methods have made great advances in modelling protein sequences for a variety of downstream tasks. The representation used as input for these models has been primarily the sequence of amino acids. Outeiral and Deane show that using codon sequences instead can improve protein representations and lead to model performance.

    • Carlos Outeiral
    • Charlotte M. Deane
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 6, P: 170-179
  • A general-purpose protein language model rapidly improves antibody properties.

    • Carlos Outeiral
    • Charlotte M. Deane
    News & Views
    Nature Biotechnology
    Volume: 42, P: 185-186
  • Ticks inject evasins at the bite site to bind multiple redundant chemokines and inhibit inflammation allowing blood feeding. Here, the authors identify evasin derived short peptides with broad spectrum anti-chemokine activity that could be used to develop new treatments for inflammatory disease.

    • Serena Vales
    • Jhanna Kryukova
    • Shoumo Bhattacharya
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • The conformational flexibility of monoribonucleotides can make interpreting their vibrational spectra challenging. Here a combination of classical and ab initio molecular dynamics is used to calculate the contributions of different monoribonucleotide conformers to experimental Raman spectra.

    • Alex L. Wilson
    • Carlos Outeiral
    • Andrew Almond
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-9